Tag Content
SG ID
SG00000004 
UniProt Accession
Theoretical PI
5.34  
Molecular Weight
37564 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
eDmc1 
Gene Synonyms/Alias
Dmc1 
Protein Name
 
Protein Synonyms/Alias
SubName: Dmc1 proteinSubName: RecA homolog DMC1 
Organism
Anguilla japonica (Japanese eel) 
NCBI Taxonomy ID
7937 
Chromosome Location
chr:-;---;-
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. H. Kajiura-Kobayashi, T. Kobayashi and Y. Nagahama (2005) Cloning of cDNAs and the differential expression of A-type cyclins and Dmc1 during spermatogenesis in the Japanese eel, a teleost fish. Dev Dyn 232(4): 1115-23. 

Abstract
We cloned A-type cyclins (cyclins A1 and A2) and Dmc1 cDNAs from the eel testis. Cyclin A1 mRNA was predominantly expressed in the livers, ovaries, and testes of the eels. In contrast to cyclin A1 mRNA, a very high expression of cyclin A2 mRNA was observed in the brains, livers, kidneys, spleens, ovaries, and testes of the eels. Dmc1 mRNA was predominantly expressed in the testes and ovaries; expression in the brain was also detected. In the eel testis, a few type-A spermatogonia incorporating 5-bromo-2'-deoxyuridine (BrdU) were seen before the initiation of spermatogenesis by hormonal induction. On day 1 after hormonal induction, the number of BrdU-labeled spermatogonia increased remarkably, and after 3 and 6 days, many labeled type-B spermatogonia were also observed. The expression of cyclin A2 increased 1 day after the induction of spermatogenesis and reached a plateau after 6 days, when many type-B spermatogonia with high proliferative activity were found. In contrast, the expression of cyclin A1 mRNA was detected after 9 days, coincident with the first appearance of spermatocytes. Cyclin A1 mRNA was localized in germ cells of all stages, from primary spermatocytes to round spermatids, whereas cyclin A2 mRNA was specifically localized in spermatogonia, secondary spermatocytes, round spermatids, and testicular somatic cells, including Sertoli cells. Dmc1 was localized only in the earlier stages of primary spermatocytes; before this stage, cyclin A1 mRNA was not detectable. Overall, cyclin A2, Dmc1, and cyclin A1 are expressed in spermatogenic cells sequentially before and during meiosis in the eel testis. PMID: [15736222] 

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Figures for illustrating the function of this protein/gene
Ref: H. Kajiura-Kobayashi, T. Kobayashi and Y. Nagahama (2005) Cloning of cDNAs and the differential expression of A-type cyclins and Dmc1 during spermatogenesis in the Japanese eel, a teleost fish. Dev Dyn 232(4): 1115-23. PMID: [15736222]
Ref: H. Kajiura-Kobayashi, T. Kobayashi and Y. Nagahama (2005) Cloning of cDNAs and the differential expression of A-type cyclins and Dmc1 during spermatogenesis in the Japanese eel, a teleost fish. Dev Dyn 232(4): 1115-23. PMID: [15736222]
Function
 
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Subcellular Location
 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005634 C:nucleus IEA:InterPro.
GO:0005524 F:ATP binding ISS:UniProtKB.
GO:0016887 F:ATPase activity ISS:UniProtKB.
GO:0008094 F:DNA-dependent ATPase activity IEA:InterPro.
GO:0003690 F:double-stranded DNA binding ISS:UniProtKB.
GO:0000150 F:recombinase activity ISS:UniProtKB.
GO:0003697 F:single-stranded DNA binding ISS:UniProtKB.
GO:0007131 P:reciprocal meiotic recombination IEA:InterPro.
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Interpro
IPR003593;    AAA+_ATPase.
IPR011940;    DMC1_rcmbase.
IPR013632;    DNA_recomb/repair_Rad51_C.
IPR016467;    DNA_recomb/repair_RecA-like.
IPR020588;    DNA_recomb_RecA/RadB_ATP-bd.
IPR010995;    DNA_repair_Rad51/TF_NusA_a-hlx.
IPR020587;    RecA_monomer-monomer_interface.
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Pfam
PF08423;    Rad51;    1.
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SMART
SM00382;    AAA;    1.
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PROSITE
PS50162;    RECA_2;    1.
PS50163;    RECA_3;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
Nucleotide Sequence
Length: 1398 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 339 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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