SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000021 
UniProt Accession
Theoretical PI
5.6  
Molecular Weight
31966 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
WBP2NL 
Gene Synonyms/Alias
PAWP 
Protein Name
Postacrosomal sheath WW domain-binding protein 
Protein Synonyms/Alias
WW domain-binding protein 2-like; 
Organism
Bos taurus (Bovine) 
NCBI Taxonomy ID
9913 
Chromosome Location
chr:5;113511509-113541197;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. A. T. Wu, P. Sutovsky, W. Xu, A. C. van der Spoel, F. M. Platt and R. Oko (2007) The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport. Dev Biol 312(2): 471-83. 

Abstract
PAWP (postacrosomal sheath WW domain-binding protein) exclusively resides in the postacrosomal sheath (PAS) of the sperm perinuclear theca (PT). Because of the importance of this region in initiating oocyte activation during mammalian fertilization [Sutovsky, P., Manandhar, G., Wu, A., Oko, R., 2003. Interactions of sperm perinuclear theca with the oocyte PMID: [17988661] 

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Figures for illustrating the function of this protein/gene
Function
May play a role in meotic resumption and pronuclearformation, mediated by a WW domain-signaling pathway duringfertilization. 
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Subcellular Location
 
Tissue Specificity
Expressed in testis. 
Gene Ontology
GO IDGO termEvidence
GO:0033011 C:perinuclear theca IDA:HGNC.
GO:0007343 P:egg activation IDA:HGNC.
GO:0035038 P:female pronucleus assembly IDA:MGI.
GO:0035039 P:male pronucleus assembly IDA:HGNC.
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Interpro
IPR004182;    GRAM.
IPR018826;    WW-domain-binding.
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Pfam
PF02893;    GRAM;    1.
PF10349;    WWbp;    3.
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SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    313       Postacrosomal sheath WW domain-binding
                             protein.
                             /FTId=PRO_0000289126.
DOMAIN        8     87       GRAM.
REPEAT      179    185       1.
REPEAT      193    199       2.
REPEAT      207    213       3.
REPEAT      214    220       4.
REPEAT      221    227       5.
REPEAT      228    234       6.
REPEAT      235    241       7.
REPEAT      242    248       8.
REPEAT      249    255       9.
REPEAT      256    262       10.
REPEAT      263    269       11.
REPEAT      270    276       12.
REGION      179    276       12 X 7 AA tandem repeat of Y-G-X-P-P-X-G.
MOTIF       183    186       WW-binding 1.
MOTIF       281    284       WW-binding 2.
COMPBIAS    170    287       Pro-rich.
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Nucleotide Sequence
Length: 1413 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 313 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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