SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000022 
UniProt Accession
Theoretical PI
5.94  
Molecular Weight
61640 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
WASF1 
Gene Synonyms/Alias
 
Protein Name
Wiskott-Aldrich syndrome protein family member 1 
Protein Synonyms/Alias
WASP family protein member 1 Protein WAVE-1; 
Organism
Bos taurus (Bovine) 
NCBI Taxonomy ID
9913 
Chromosome Location
chr:9;40520685-40591232;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. 

Abstract
BACKGROUND PMID: [15471936] 

Back to Top
Figures for illustrating the function of this protein/gene
Ref: V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. PMID: [15471936]
Ref: V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. PMID: [15471936]
Ref: V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. PMID: [15471936]
Ref: V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. PMID: [15471936]
Ref: V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. PMID: [15471936]
Function
Downstream effector molecule involved in thetransmission of signals from tyrosine kinase receptors and smallGTPases to the actin cytoskeleton. Promotes formation of actinfilaments. Part of the WAVE complex that regulates lamellipodiaformation. The WAVE complex regulates actin filamentreorganization via its interaction with the Arp2/3 complex (Bysimilarity). 
Back to Top
Subcellular Location
Cytoplasm, cytoskeleton (By similarity).Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (By similarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005856 C:cytoskeleton IEA:UniProtKB-SubCell.
GO:0030027 C:lamellipodium IEA:Compara.
GO:0005741 C:mitochondrial outer membrane IEA:Compara.
Back to Top
Interpro
IPR003124;    WH2_dom.
Back to Top
Pfam
PF02205;    WH2;    1.
Back to Top
SMART
SM00246;    WH2;    1.
Back to Top
PROSITE
PS51082;    WH2;    1.
Back to Top
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    559       Wiskott-Aldrich syndrome protein family
                             member 1.
                             /FTId=PRO_0000279721.
DOMAIN      497    514       WH2.
COMPBIAS    275    492       Pro-rich.
Back to Top
Nucleotide Sequence
Length: bp   Go to nucleotide: FASTA
Protein Sequence
Length: 559 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
Comments