SG ID

SG00000025 

UniProt Accession

G3MY63_BOVIN;G3MY63;  

Theoretical PI

5.73  

Molecular Weight

29703 Da  

Genbank Nucleotide ID

DAAA02005516; DAAA02005517; DAAA02005518;  

Genbank Protein ID

 

Gene Name

BT.25777 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Uncharacterized protein 

Bos taurus (Bovine) 

9913 

Temporarily unavailable 

The information of related literatures

1. Q. Zhang, J. Li, Q. Li, X. Li, Z. Liu, D. Song and Z. Xie (2009) Cloning and characterization of the gene encoding the bovine BOULE protein. Mol Genet Genomics 281(1): 67-75. 

Abstract
The Deleted in Azoospermia (DAZ) genes encode potential RNA-binding proteins that are expressed exclusively in the germ-line. The bovine Deleted in Azoospermia-like gene is a strong candidate for male cattle-yak infertility. In this work, with the goe goal to further reveal the genetic cause of male cattle-yak sterility, another bovine DAZ family gene, b-boule, was isolated and characterized. The b-boule gene is predicted to encode a polypeptide of 295 amino acids with an RNP-type RNA recognition domain. Tertiary structure analysis shows that b-boule binds specifically to polypyrimidine RNAs and might act as a nuclear ribonucleoprotein particle auxiliary factor during germ cell formation and morphological changes of germ cells. RT-PCR assays revealed that b-boule was expressed specifically in the adult testis. However, an extremely low level of expression was detected in the testis of sterile male cattle-yaks. Microstructure of the testes from sterile males showed that type A spermatogonia were the only germ cells present and that few germ cells developed further than the stage of pachytene spermatocytes. These results suggest that b-boule may function in bovine spermatogenesis, and that low levels of b-boule expression might lead to male sterility in cattle-yaks. PMID: [18987886] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0003676	F:nucleic acid binding	IEA:InterPro.
GO:0000166	F:nucleotide binding	IEA:InterPro.

Back to Top

Interpro

IPR012677;    Nucleotide-bd_a/b_plait.
IPR000504;    RRM_dom.
Back to Top

Pfam

PF00076;    RRM_1;    1.
Back to Top

SMART

SM00360;    RRM;    1.
Back to Top

PROSITE

PS50102;    RRM;    1.
Back to Top

PRINTS

Back to Top

Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 271 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

Comments