SG ID

SG00000028 

UniProt Accession

G5E6H6_BOVIN;G5E6H6;  

Theoretical PI

7.15  

Molecular Weight

42846 Da  

Genbank Nucleotide ID

DAAA02045104;  

Genbank Protein ID

 

Gene Name

Bt.89360 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Uncharacterized protein 

Bos taurus (Bovine) 

9913 

Temporarily unavailable 

The information of related literatures

1. C. K. Hamilton, T. Revay, R. Domander, L. A. Favetta and W. A. King (2011) A large expansion of the HSFY gene family in cattle shows dispersion across Yq and testis-specific expression. PLoS One 6(3): e17790. 

Abstract
Heat shock transcription factor, Y-linked (HSFY) is a member of the heat shock transcriptional factor (HSF) family that is found in multiple copies on the Y chromosome and conserved in a number of species. Its function still remains unknown but in humans it is thought to play a role in spermatogenesis. Through real time polymerase chain reaction (PCR) analyses we determined that the HSFY family is largely expanded in cattle ( approximately 70 copies) compared with human (2 functional copies, 4 HSFY-similar copies). Unexpectedly, we found that it does not vary among individual bulls as a copy number variant (CNV). Using fluorescence in situ hybridization (FISH) we found that the copies are dispersed along the long arm of the Y chromosome (Yq). HSFY expression in cattle appears restricted to the testis and its mRNA correlates positively with mRNA markers of spermatogonial and spermatocyte cells (UCHL1 and TRPC2, respectively) which suggests that HSFY is expressed (at least in part) in early germ cells. PMID: [21408193] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005634	C:nucleus	IEA:UniProtKB-KW.
GO:0043565	F:sequence-specific DNA binding	IEA:InterPro.
GO:0003700	F:sequence-specific DNA binding transcription factor activity	IEA:InterPro.

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Interpro

IPR000232;    HSF_DNA-bd.
IPR011991;    WHTH_trsnscrt_rep_DNA-bd.
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Pfam

PF00447;    HSF_DNA-bind;    1.
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SMART

SM00415;    HSF;    1.
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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 375 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

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