Tag Content
SG ID
SG00000043 
UniProt Accession
Theoretical PI
7.33  
Molecular Weight
61061 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
puf-8 
Gene Synonyms/Alias
ORFNames=CELE_C30G12.7 
Protein Name
 
Protein Synonyms/Alias
SubName: Protein PUF-8 
Organism
Caenorhabditis elegans 
NCBI Taxonomy ID
6239 
Chromosome Location
chr:II;7296079-7298206;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. K. Subramaniam and G. Seydoux (2003) Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans lacking the pumilio-like protein PUF-8. Curr Biol 13(2): 134-9. 

Abstract
PUF proteins are a conserved family of RNA binding proteins that regulate RNA stability and translation by binding to specific sequences in 3'-untranslated regions. Drosophila PUMILIO and C. elegans FBF are essential for self-renewal of germline stem cells, suggesting that a common function of PUF proteins may be to sustain mitotic proliferation of stem cells. Here, we show that PUF-8, the C. elegans PUF most related to PUMILIO, performs a different function in germ cells that have begun meiosis PMID: [12546787] 

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Figures for illustrating the function of this protein/gene
Ref: K. Subramaniam and G. Seydoux (2003) Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans lacking the pumilio-like protein PUF-8. Curr Biol 13(2): 134-9. PMID: [12546787]
Ref: K. Subramaniam and G. Seydoux (2003) Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans lacking the pumilio-like protein PUF-8. Curr Biol 13(2): 134-9. PMID: [12546787]
Ref: K. Subramaniam and G. Seydoux (2003) Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans lacking the pumilio-like protein PUF-8. Curr Biol 13(2): 134-9. PMID: [12546787]
Ref: K. Subramaniam and G. Seydoux (2003) Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans lacking the pumilio-like protein PUF-8. Curr Biol 13(2): 134-9. PMID: [12546787]
Function
 
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Subcellular Location
 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005622 C:intracellular IDA:WormBase.
GO:0003723 F:RNA binding ISS:WormBase.
GO:0040022 P:feminization of hermaphroditic germ-line IMP:WormBase.
GO:0007140 P:male meiosis IMP:WormBase.
GO:0040027 P:negative regulation of vulval development IMP:WormBase.
GO:0042127 P:regulation of cell proliferation IMP:WormBase.
GO:0040020 P:regulation of meiosis IMP:WormBase.
GO:0006417 P:regulation of translation TAS:WormBase.
GO:0007283 P:spermatogenesis IMP:WormBase.
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Interpro
IPR011989;    ARM-like.
IPR016024;    ARM-type_fold.
IPR001313;    Pumilio_RNA-bd_rpt.
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Pfam
PF00806;    PUF;    5.
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SMART
SM00025;    Pumilio;    8.
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PROSITE
PS50302;    PUM;    8.
PS50303;    PUM_HD;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
Nucleotide Sequence
Length: bp   Go to nucleotide: FASTA
Protein Sequence
Length: 535 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
POP2DIP 
skpt-1BioGRID 
ccf-1DIP 
skpt-1IntAct 
skpt-1BioGRID 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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