SG ID

SG00000049 

UniProt Accession

Q20053_CAEEL;Q20053;  

Theoretical PI

8.87  

Molecular Weight

34368 Da  

Genbank Nucleotide ID

Z46242;  

Genbank Protein ID

CAA86329.1; 

Gene Name

asb-1 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Protein ASB-1 

Caenorhabditis elegans 

6239 

Temporarily unavailable 

The information of related literatures

1. I. Kawasaki, M. Hanazawa, K. Gengyo-Ando, S. Mitani, I. Maruyama and Y. Iino (2007) ASB-1, a germline-specific isoform of mitochondrial ATP synthase b subunit, is required to maintain the rate of germline development in Caenorhabditis elegans. Mech Dev 124(3): 237-51. 

Abstract
The developmental timing of all types of cells must be synchronized and spatially coordinated to achieve the organized development of a multicellular organism. Previously, we found RNAi of asb-1, encoding a germline-specific isoform of mitochondrial ATP synthase b subunit, caused 100% penetrant sterility in Caenorhabditis elegans. ATP synthase is one of the five complexes of the mitochondrial respiratory chain, and defects in some of the components of the chain are known to slow the growth and extend the lifespan of worms. We found that development of asb-1 mutant germ line was not arrested at any stage, but did slow to half the rate of wild type, whereas the rate of somatic development was the same in asb-1 mutants as that of wild type, indicating that asb-1 is required to maintain the rate of germline development but has no effect on somatic development. Among ATP synthase subunit genes, RNAi of asg-1, encoding a germline-specific isoform of the g subunit, also caused asb-1-like sterility, indicating that some other germline-specific components are also required to maintain the rate of germline development. Both asb-1 and asg-1 are located on autosomes while they possess counterparts, asb-2 and asg-2, respectively, on X chromosome, which are both required for somatic development. Chromosomal locations of the genes may be the basis of the segregation of germline/somatic functions of each gene, as were demonstrated for other autosomal/X-linked duplicated gene pairs. PMID: [17223323] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005929	C:cilium	IDA:WormBase.
GO:0000276	C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	IBA:RefGenome.
GO:0046933	F:hydrogen ion transporting ATP synthase activity, rotational mechanism	IBA:RefGenome.
GO:0015986	P:ATP synthesis coupled proton transport	IBA:RefGenome.
GO:0009792	P:embryo development ending in birth or egg hatching	IMP:WormBase.
GO:0040027	P:negative regulation of vulval development	IMP:WormBase.
GO:0040010	P:positive regulation of growth rate	IMP:WormBase.
GO:0000003	P:reproduction	IMP:WormBase.

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Interpro

IPR008688;    ATPase_F0-cplx_bsu_mt.
IPR013837;    ATPase_F0-cplx_bsu_mt_met.
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Pfam

PF05405;    Mt_ATP-synt_B;    1.
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SMART

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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 39709 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 301 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt	Gene Symbol	Ref Databases
BAR1_CAEEL	bar-1	BioGRID
CLK2_CAEEL	clk-2	BioGRID
EGL15_CAEEL	egl-15	BioGRID
INSR_CAEEL	daf-2	BioGRID

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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