SG ID

SG00000054 

UniProt Accession

O01798_CAEEL;O01798;  

Theoretical PI

8.99  

Molecular Weight

57802 Da  

Genbank Nucleotide ID

FO081455;  

Genbank Protein ID

CCD71705.1; 

Gene Name

spe-8 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Protein SPE-8 

Caenorhabditis elegans 

6239 

Temporarily unavailable 

The information of related literatures

1. S. W. L'Hernault, D. C. Shakes and S. Ward (1988) Developmental genetics of chromosome I spermatogenesis-defective mutants in the nematode Caenorhabditis elegans. Genetics 120(2): 435-52. 

Abstract
Mutations affecting Caenorhabditis elegans spermatogenesis can be used to dissect the processes of meiosis and spermatozoan morphological maturation. We have obtained 23 new chromosome I mutations that affect spermatogenesis (spe mutations). These mutations, together with six previously described mutations, identify 11 complementation groups, of which six are defined by multiple alleles. These spe mutations are all recessive and cause normally self-fertile hermaphrodites to produce unfertilized oocytes that can be fertilized by wild-type male sperm. Five chromosome I mutation/deficiency heterozygotes have similar phenotypes to the homozygote showing that the probable null phenotype of these genes is defective sperm. Spermatogenesis is disrupted at different steps by mutations in these genes. The maturation of 1 degree spermatocytes is disrupted by mutations in spe-4 and spe-5. Spermatids from spe-8 and spe-12 mutants develop into normal spermatozoa in males, but not in hermaphrodites. fer-6 spermatids are abnormal, and fer-1 spermatids look normal but subsequently become abnormal spermatozoa. Mutations in five genes (fer-7, spe-9, spe-11, spe-13 and spe-15) allow formation of normal looking motile spermatozoa that appear to be defective in either sperm-spermathecal or sperm-oocyte interactions. PMID: [3197956] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005524	F:ATP binding	IEA:UniProtKB-KW.
GO:0004713	F:protein tyrosine kinase activity	IEA:UniProtKB-KW.
GO:0007286	P:spermatid development	IMP:WormBase.

Back to Top

Interpro

IPR011009;    Kinase-like_dom.
IPR000719;    Prot_kinase_cat_dom.
IPR017441;    Protein_kinase_ATP_BS.
IPR001245;    Ser-Thr/Tyr_kinase_cat_dom.
IPR000980;    SH2.
IPR008266;    Tyr_kinase_AS.
IPR020635;    Tyr_kinase_cat_dom.
Back to Top

Pfam

PF07714;    Pkinase_Tyr;    1.
PF00017;    SH2;    1.
Back to Top

SMART

SM00252;    SH2;    1.
SM00219;    TyrKc;    1.
Back to Top

PROSITE

PS00107;    PROTEIN_KINASE_ATP;    1.
PS50011;    PROTEIN_KINASE_DOM;    1.
PS00109;    PROTEIN_KINASE_TYR;    1.
PS50001;    SH2;    1.
Back to Top

PRINTS

PR00109;    TYRKINASE.;   
Back to Top

Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 512 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

Comments