SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000056 
UniProt Accession
Theoretical PI
7.87  
Molecular Weight
70358 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
fbf-1 
Gene Synonyms/Alias
ORFNames=H12I13.4 
Protein Name
Fem-3 mRNA-binding factor 1 
Protein Synonyms/Alias
 
Organism
Caenorhabditis elegans 
NCBI Taxonomy ID
6239 
Chromosome Location
chr:II;6078239-6080785;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. N. Suh, S. L. Crittenden, A. Goldstrohm, B. Hook, B. Thompson, M. Wickens and J. Kimble (2009) FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline. Genetics 181(4): 1249-60. 

Abstract
FBF, a PUF RNA-binding protein, is a key regulator of the mitosis/meiosis decision in the Caenorhabditis elegans germline. Genetically, FBF has a dual role in this decision PMID: [19221201] 

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Figures for illustrating the function of this protein/gene
Function
Involved in the control of stem cells and sexdetermination in the C.elegans hermaphrodite germline. May alsoplay a role in the hermaphrodite germline proliferation andoogenesis. Binds specifically to the regulatory region of fem-33'-UTR and mediates the sperm/oocyte switch. Negatively regulatesgld-3 expression, possibly by directly binding to two sites withinthe 3'-UTR of gld-3 isoform B. 
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Subcellular Location
Cytoplasm. 
Tissue Specificity
Expressed specifically in the germline (atprotein level). 
Gene Ontology
GO IDGO termEvidence
GO:0043073 C:germ cell nucleus IDA:WormBase.
GO:0048471 C:perinuclear region of cytoplasm IDA:WormBase.
GO:0003730 F:mRNA 3'-UTR binding IDA:WormBase.
GO:0030154 P:cell differentiation IEA:UniProtKB-KW.
GO:0009792 P:embryo development ending in birth or egg hatching IMP:WormBase.
GO:0040022 P:feminization of hermaphroditic germ-line IMP:WormBase.
GO:0051729 P:germline cell cycle switching, mitotic to meiotic cell cycle IMP:WormBase.
GO:0040011 P:locomotion IMP:WormBase.
GO:0017148 P:negative regulation of translation IGI:WormBase.
GO:0040027 P:negative regulation of vulval development IMP:WormBase.
GO:0007548 P:sex differentiation IEA:UniProtKB-KW.
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Interpro
IPR011989;    ARM-like.
IPR016024;    ARM-type_fold.
IPR001313;    Pumilio_RNA-bd_rpt.
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Pfam
PF00806;    PUF;    1.
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SMART
SM00025;    Pumilio;    8.
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PROSITE
PS50302;    PUM;    8.
PS50303;    PUM_HD;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    614       Fem-3 mRNA-binding factor 1.
                             /FTId=PRO_0000075932.
DOMAIN      160    564       PUM-HD.
REPEAT      185    223       Pumilio 1.
REPEAT      224    263       Pumilio 2.
REPEAT      269    305       Pumilio 3.
REPEAT      306    342       Pumilio 4.
REPEAT      343    382       Pumilio 5.
REPEAT      398    434       Pumilio 6.
REPEAT      436    471       Pumilio 7.
REPEAT      483    519       Pumilio 8.
REGION      283    614       Binding to gld-3 isoform A.
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Nucleotide Sequence
Length: bp   Go to nucleotide: FASTA
Protein Sequence
Length: 614 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
cpb-1IntAct 
cpb-1IntAct 
nos-3IntAct 
nos-3IntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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