1. C. C. Conine, P. J. Batista, W. Gu, J. M. Claycomb, D. A. Chaves, M. Shirayama and C. C. Mello (2010) Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans. Proc Natl Acad Sci U S A 107(8): 3588-93.
Abstract Gametogenesis is a thermosensitive process in numerous metazoans, ranging from worms to man. In Caenorhabditis elegans, a variety of RNA-binding proteins that associate with germ-line nuage (P granules), including the Piwi-clade argonaute PRG-1, have been implicated in maintaining fertility at elevated temperature. Here we describe the role of two AGO-class paralogs, alg-3 (T22B3.2) and alg-4 (ZK757.3), in promoting thermotolerant male fertility. A rescuing GFP PMID: [20133686]
Figures for illustrating the function of this protein/gene
Ref: C. C. Conine, P. J. Batista, W. Gu, J. M. Claycomb, D. A. Chaves, M. Shirayama and C. C. Mello (2010) Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans. Proc Natl Acad Sci U S A 107(8): 3588-93. PMID: [20133686]
Ref: C. C. Conine, P. J. Batista, W. Gu, J. M. Claycomb, D. A. Chaves, M. Shirayama and C. C. Mello (2010) Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans. Proc Natl Acad Sci U S A 107(8): 3588-93. PMID: [20133686]