Tag Content
SG ID
SG00000084 
UniProt Accession
Theoretical PI
5.83  
Molecular Weight
63337 Da  
Genbank Nucleotide ID
 
Genbank Protein ID
 
Gene Name
OCLN 
Gene Synonyms/Alias
 
Protein Name
 
Protein Synonyms/Alias
SubName: Occludin 
Organism
Canis familiaris (Dog) (Canis lupus familiaris) 
NCBI Taxonomy ID
9615 
Chromosome Location
chr:2;57373401-57418138;1
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Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. M. C. Gye (2004) Expression of occludin in canine testis and epididymis. Reprod Domest Anim 39(1): 43-7. 

Abstract
Tight junctions (TJ) in inter-Sertoli junctional areas and epididymal epithelia are important for the formation of blood-testis barrier (BTB) and blood-epididymal barrier (BEB). In this study, the expression of occludin, an integral member of the TJ, was verified in canine testis and epididymis. Both low molecular weight (MW) (25-28 kDa) forms as well as high MW (68-72 kDa) forms of occludin were detected in the testis and epididymis using Western blot. The relative amount of the high MW forms of occludin vs low MW forms was higher in the testis than in the epididymis. Some difference in the composition of different MW forms of occludin was found along the segments of epididymis, suggesting the possible correlation between cellular composition of occludin proteins and paracellular permeability of epithelia along the epididymal tubule. In the testis, intense occludin immunoreactivity was found in the basally located inter-Sertoli junctional area. Diffused immunoreactivity of occludin was also found in the cytoplasm of Sertoli cells. A similar pattern of zonula occludens-1 immunoreactivity was found in the cytoplasm of Sertoli cells, suggesting that occludin was not confined to the inter-Sertoli junctional areas and that subcellular localization of occludin in the Sertoli cells was dynamically regulated during spermatogenesis in canine testis. In the epididymis weak immunoreactivity was found in the apical sides and cytoplasm of epithelial cells. PMID: [15129920] 

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Figures for illustrating the function of this protein/gene
Function
 
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Subcellular Location
 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0016021 C:integral to membrane IEA:UniProtKB-KW.
GO:0005923 C:tight junction IEA:Compara.
GO:0005198 F:structural molecule activity IEA:InterPro.
GO:0045216 P:cell-cell junction organization IEA:Compara.
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Interpro
IPR008253;    Marvel.
IPR021128;    MARVEL-like_dom.
IPR002958;    Occludin.
IPR010844;    Occludin_RNApol2_elong_fac_ELL.
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Pfam
PF01284;    MARVEL;    1.
PF07303;    Occludin_ELL;    1.
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SMART
PROSITE
PS51225;    MARVEL;    1.
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PRINTS
PR01258;    OCCLUDIN.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
Nucleotide Sequence
Length: bp   Go to nucleotide: FASTA
Protein Sequence
Length: 559 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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