SG ID

SG00000086 

UniProt Accession

E2RP23_CANFA;E2RP23;  

Theoretical PI

6.13  

Molecular Weight

52518 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

SMAD2 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Uncharacterized protein 

Canis familiaris (Dog) (Canis lupus familiaris) 

9615 

Temporarily unavailable 

The information of related literatures

1. X. J. Zhang, J. P. He, X. X. Wen and L. Zhao (2011) Immunolocalisation and expression of Smad2 and Smad4 proteins in dog testis during postnatal development. Andrologia 43(4): 254-60. 

Abstract
The expression and localisation of downstream signalling molecules of transforming growth factor beta superfamily, Smad2 and Smad4 proteins, was investigated in immature and mature dog testis. Cellular localisation of Smad2 and Smad4 proteins was examined using immunohistochemistry. Quantitative analysis of immunostaining was determined by the image analysis system. The specificity of the antibodies was examined using Western blotting assay. Smad2 and Smad4 were widely expressed in the testes, mainly immunolocalised in the cytoplasm of gonocytes, Leydig cells and Sertoli cells of immature testes, and Leydig cells and Sertoli cells of mature testes. At the same time, the expression levels for both proteins were different between immature and mature age groups PMID: [21486406] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0032444	C:activin responsive factor complex	IEA:Compara.
GO:0005737	C:cytoplasm	IEA:Compara.
GO:0071141	C:SMAD protein complex	IEA:Compara.
GO:0003682	F:chromatin binding	IEA:Compara.
GO:0003690	F:double-stranded DNA binding	IEA:Compara.
GO:0003700	F:sequence-specific DNA binding transcription factor activity	IEA:Compara.
GO:0030618	F:transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	IEA:Compara.
GO:0009952	P:anterior/posterior pattern specification	IEA:Compara.
GO:0045165	P:cell fate commitment	IEA:Compara.
GO:0007182	P:common-partner SMAD protein phosphorylation	IEA:Compara.
GO:0048589	P:developmental growth	IEA:Compara.
GO:0048701	P:embryonic cranial skeleton morphogenesis	IEA:Compara.
GO:0048617	P:embryonic foregut morphogenesis	IEA:Compara.
GO:0007492	P:endoderm development	IEA:Compara.
GO:0001701	P:in utero embryonic development	IEA:Compara.
GO:0030073	P:insulin secretion	IEA:Compara.
GO:0035556	P:intracellular signal transduction	IEA:Compara.
GO:0030324	P:lung development	IEA:Compara.
GO:0001707	P:mesoderm formation	IEA:Compara.
GO:0045892	P:negative regulation of transcription, DNA-dependent	IEA:Compara.
GO:0038092	P:nodal signaling pathway	IEA:Compara.
GO:0035265	P:organ growth	IEA:Compara.
GO:0060021	P:palate development	IEA:Compara.
GO:0031016	P:pancreas development	IEA:Compara.
GO:0048340	P:paraxial mesoderm morphogenesis	IEA:Compara.
GO:0060039	P:pericardium development	IEA:Compara.
GO:0030513	P:positive regulation of BMP signaling pathway	IEA:Compara.
GO:0010718	P:positive regulation of epithelial to mesenchymal transition	IEA:Compara.
GO:1900224	P:positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	IEA:Compara.
GO:0045944	P:positive regulation of transcription from RNA polymerase II promoter	IEA:Compara.
GO:0009791	P:post-embryonic development	IEA:Compara.
GO:0051098	P:regulation of binding	IEA:Compara.
GO:0017015	P:regulation of transforming growth factor beta receptor signaling pathway	IEA:Compara.
GO:0070723	P:response to cholesterol	IEA:Compara.
GO:0009749	P:response to glucose stimulus	IEA:Compara.
GO:0007183	P:SMAD protein complex assembly	IEA:Compara.
GO:0006351	P:transcription, DNA-dependent	IEA:UniProtKB-KW.
GO:0007179	P:transforming growth factor beta receptor signaling pathway	IEA:Compara.
GO:0001657	P:ureteric bud development	IEA:Compara.
GO:0007352	P:zygotic specification of dorsal/ventral axis	IEA:Compara.

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Interpro

IPR013790;    Dwarfin.
IPR003619;    MAD_homology1_Dwarfin-type.
IPR013019;    MAD_homology_MH1.
IPR017855;    SMAD_dom-like.
IPR001132;    SMAD_dom_Dwarfin-type.
IPR008984;    SMAD_FHA_domain.
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Pfam

PF03165;    MH1;    1.
PF03166;    MH2;    1.
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SMART

SM00523;    DWA;    1.
SM00524;    DWB;    1.
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PROSITE

PS51075;    MH1;    1.
PS51076;    MH2;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 469 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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