SG ID

SG00000087 

UniProt Accession

MEN1_CANFA;A2SXS5;E2RDP0;  

Theoretical PI

6.14  

Molecular Weight

67962 Da  

Genbank Nucleotide ID

DQ366289;  

Genbank Protein ID

ABD16380.1; 

Gene Name

MEN1 

Gene Synonyms/Alias

 

Protein Name

Menin 

Protein Synonyms/Alias

 

Canis familiaris (Dog) (Canis lupus familiaris) 

9615 

Temporarily unavailable 

The information of related literatures

1. X. J. Zhang, J. P. He, X. X. Wen and L. Zhao (2011) Immunolocalisation and expression of Smad2 and Smad4 proteins in dog testis during postnatal development. Andrologia 43(4): 254-60. 

Abstract
The expression and localisation of downstream signalling molecules of transforming growth factor beta superfamily, Smad2 and Smad4 proteins, was investigated in immature and mature dog testis. Cellular localisation of Smad2 and Smad4 proteins was examined using immunohistochemistry. Quantitative analysis of immunostaining was determined by the image analysis system. The specificity of the antibodies was examined using Western blotting assay. Smad2 and Smad4 were widely expressed in the testes, mainly immunolocalised in the cytoplasm of gonocytes, Leydig cells and Sertoli cells of immature testes, and Leydig cells and Sertoli cells of mature testes. At the same time, the expression levels for both proteins were different between immature and mature age groups PMID: [21486406] 

Figures for illustrating the function of this protein/gene

Function

Essential component of a MLL/SET1 histonemethyltransferase (HMT) complex, a complex that specificallymethylates 'Lys-4' of histone H3 (H3K4). Functions as atranscriptional regulator. Binds to the TERT promoter andrepresses telomerase expression. Plays a role in TGFB1-mediatedinhibition of cell-proliferation, possibly regulating SMAD3transcriptional activity. Represses JUND-mediated transcriptionalactivation on AP1 sites, as well as that mediated by NFKB subunitRELA. Positively regulates HOXC8 and HOXC6 gene expression. May beinvolved in normal hematopoiesis through the activation of HOXA9expression. May be involved in DNA repair (By similarity). 

Subcellular Location

Nucleus (By similarity). 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0000785	C:chromatin	IEA:Compara.
GO:0032154	C:cleavage furrow	IEA:Compara.
GO:0005829	C:cytosol	IEA:Compara.
GO:0035097	C:histone methyltransferase complex	IEA:Compara.
GO:0016363	C:nuclear matrix	IEA:Compara.
GO:0005625	C:soluble fraction	IEA:Compara.
GO:0003682	F:chromatin binding	IEA:Compara.
GO:0003690	F:double-stranded DNA binding	IEA:Compara.
GO:0000400	F:four-way junction DNA binding	IEA:Compara.
GO:0018024	F:histone-lysine N-methyltransferase activity	IEA:Compara.
GO:0043565	F:sequence-specific DNA binding	IEA:Compara.
GO:0044212	F:transcription regulatory region DNA binding	IEA:Compara.
GO:0000403	F:Y-form DNA binding	IEA:Compara.
GO:0007050	P:cell cycle arrest	IEA:Compara.
GO:0006338	P:chromatin remodeling	IEA:Compara.
GO:0048704	P:embryonic skeletal system morphogenesis	IEA:Compara.
GO:0030097	P:hemopoiesis	IEA:Compara.
GO:0001776	P:leukocyte homeostasis	IEA:Compara.
GO:0000165	P:MAPK cascade	IEA:Compara.
GO:0060135	P:maternal process involved in female pregnancy	IEA:Compara.
GO:0008285	P:negative regulation of cell proliferation	IEA:Compara.
GO:0045736	P:negative regulation of cyclin-dependent protein kinase activity	IEA:Compara.
GO:0046329	P:negative regulation of JNK cascade	IEA:Compara.
GO:0046621	P:negative regulation of organ growth	IEA:Compara.
GO:0045668	P:negative regulation of osteoblast differentiation	IEA:Compara.
GO:0043433	P:negative regulation of sequence-specific DNA binding transcription factor activity	IEA:Compara.
GO:0051974	P:negative regulation of telomerase activity	IEA:Compara.
GO:0000122	P:negative regulation of transcription from RNA polymerase II promoter	IEA:Compara.
GO:0002076	P:osteoblast development	IEA:Compara.
GO:0002051	P:osteoblast fate commitment	IEA:Compara.
GO:0060021	P:palate development	IEA:Compara.
GO:0043065	P:positive regulation of apoptotic process	IEA:Compara.
GO:0051781	P:positive regulation of cell division	IEA:Compara.
GO:0043280	P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA:Compara.
GO:0031062	P:positive regulation of histone methylation	IEA:Compara.
GO:0045669	P:positive regulation of osteoblast differentiation	IEA:Compara.
GO:0032092	P:positive regulation of protein binding	IEA:Compara.
GO:0045944	P:positive regulation of transcription from RNA polymerase II promoter	IEA:Compara.
GO:0030511	P:positive regulation of transforming growth factor beta receptor signaling pathway	IEA:Compara.
GO:0006974	P:response to DNA damage stimulus	IEA:Compara.
GO:0010332	P:response to gamma radiation	IEA:Compara.
GO:0009411	P:response to UV	IEA:Compara.
GO:0006351	P:transcription, DNA-dependent	IEA:UniProtKB-KW.

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Interpro

IPR007747;    Menin.
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Pfam

PF05053;    Menin;    1.
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SMART

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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 615 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

Temporarily unavailable 

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