SG ID

SG00000089 

UniProt Accession

NPTX2_CAVPO;P47970;  

Theoretical PI

5.25  

Molecular Weight

47233 Da  

Genbank Nucleotide ID

U13234; U13236;  

Genbank Protein ID

AAA64994.1; AAA64995.1; 

Gene Name

NPTX2 

Gene Synonyms/Alias

 

Protein Name

Neuronal pentraxin-2 

Protein Synonyms/Alias

NP2 Acrosomal pentaxin-like protein p50;AM50 Neuronal pentraxin II;ApexinNP-IIFlags: Precursor 

Cavia porcellus (Guinea pig) 

10141 

Temporarily unavailable 

The information of related literatures

1. V. A. Westbrook-Case, V. P. Winfrey and G. E. Olson (1995) Sorting of the domain-specific acrosomal matrix protein AM50 during spermiogenesis in the guinea pig. Dev Biol 167(1): 338-49. 

Abstract
We previously identified an insoluble 50-kDa acrosomal matrix protein (AM50) localized to the ventral region of the guinea pig sperm apical segment. AM50 is converted to a 42-kDa polypeptide and released during matrix dispersion in acrosome-reacting sperm. This study examines the sorting pathways and assembly processes which generate the domain-specific distribution of AM50 in the acrosome. AM50 was expressed during early acrosome development and localized to the matrix of proacrosomal granules and the acrosomal vesicle. Initial sorting of AM50 occurred in Golgi phase spermatids, where it became concentrated in the matrix surrounding the acrosomal granule. AM50 remained restricted to the apical segment of acrosome phase spermatids and was finally sorted to the ventral matrix of the apical segment in maturation phase spermatids. By reducing SDS-PAGE testicular AM50 exhibited a slightly higher M(r) of 52 kDa than the 50-kDa form of cauda epididymal spermatozoa. Nonreducing SDS-PAGE demonstrated that testicular and epididymal AM50 were assembled into homomeric complexes of 480 and 450 kDa respectively. Cauda epididymal sperm apical segments contained a second disulfide-cross-linked homomeric complex of 520 kDa composed of a 68-kDa subunit. These studies indicate that AM50 is first assembled into a disulfide-cross-linked complex and subsequently processed into mature AM50. These data also suggest that disulfide-linked complexes of different structural proteins may assemble into distinct acrosomal matrix compartments. PMID: [7851654] 

Figures for illustrating the function of this protein/gene

Function

May be involved in binding, concentrating, and sortingsoluble glycoproteins or glycolipids that are destined for theacrosome. 

Subcellular Location

Cytoplasmic vesicle, secretory vesicle,acrosome lumen. Note=Sperm acrosomal matrix. 

Tissue Specificity

Testis specific. 

Gene Ontology

GO ID	GO term	Evidence
GO:0043160	C:acrosomal lumen	IEA:UniProtKB-SubCell.
GO:0046872	F:metal ion binding	IEA:UniProtKB-KW.

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Interpro

IPR008985;    ConA-like_lec_gl.
IPR013320;    ConA-like_subgrp.
IPR001759;    Pentaxin.
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Pfam

PF00354;    Pentaxin;    1.
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SMART

SM00159;    PTX;    1.
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PROSITE

PS00289;    PENTAXIN;    1.
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PRINTS

PR00895;    PENTAXIN.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 1572 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 427 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

Temporarily unavailable 

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