Tag Content
SG ID
SG00000094 
UniProt Accession
Theoretical PI
5.46  
Molecular Weight
69009 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Hexo1 
Gene Synonyms/Alias
Hexo1-RD 
Protein Name
 
Protein Synonyms/Alias
SubName: FI04413pSubName: Hexosaminidase 1, isoform DEC=3.2.1.52SubName: Hexosaminidase 1, isoform EEC=3.2.1.52 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:3L;4288642-4291211;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. M. E. Pasini, J. Intra, L. M. Gomulski, V. Calvenzani, K. Petroni, F. Briani and M. E. Perotti (2011) Identification and expression profiling of Ceratitis capitata genes coding for beta-hexosaminidases. Gene 473(1): 44-56. 

Abstract
The goal of this study was to identify the genes coding for beta-N-acetylhexosaminidases in the Mediterranean fruit fly (medfly) Ceratitis capitata, one of the most destructive agricultural pests, belonging to the Tephritidae family, order Diptera. Two dimeric beta-N-acetylhexosaminidases, HEXA and HEXB, have been recently identified on Drosophila sperm. These enzymes are involved in egg binding through interactions with complementary carbohydrates on the surface of the egg shell. Three genes, Hexosaminidase 1 (Hexo1), Hexosaminidase 2 (Hexo2) and fused lobes (fdl), encode for HEXA and HEXB subunits. The availability of C. capitata EST libraries derived from embryos and adult heads allowed us to identify three sequences homologous to the D. melanogaster Hexo1, Hexo2 and fdl genes. Here, we report the expression profile analysis of CcHexo1, CcHexo2 and Ccfdld in several tissues, organs and stages. Ccfdl expression was highest in heads of both sexes and in whole adult females. In the testis and ovary the three genes showed distinct spatial and temporal expression patterns. All the mRNAs were detectable in early stages of spermatogenesis; CcHexo2 and Ccfdl were also expressed in early elongating spermatid cysts. All three genes are expressed in the ovarian nurse cells. CcHexo1 and Ccfdl are stage specific, since they have been observed in stages 12 and 13 during oocyte growth, when programmed cell death occurs in nurse cells. The expression pattern of the three genes in medfly gonads suggests that, as their Drosophila counterparts, they may encode for proteins involved in gametogenesis and fertilization. PMID: [21094225] 

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Figures for illustrating the function of this protein/gene
Ref: M. E. Pasini, J. Intra, L. M. Gomulski, V. Calvenzani, K. Petroni, F. Briani and M. E. Perotti (2011) Identification and expression profiling of Ceratitis capitata genes coding for beta-hexosaminidases. Gene 473(1): 44-56. PMID: [21094225]
Ref: M. E. Pasini, J. Intra, L. M. Gomulski, V. Calvenzani, K. Petroni, F. Briani and M. E. Perotti (2011) Identification and expression profiling of Ceratitis capitata genes coding for beta-hexosaminidases. Gene 473(1): 44-56. PMID: [21094225]
Ref: M. E. Pasini, J. Intra, L. M. Gomulski, V. Calvenzani, K. Petroni, F. Briani and M. E. Perotti (2011) Identification and expression profiling of Ceratitis capitata genes coding for beta-hexosaminidases. Gene 473(1): 44-56. PMID: [21094225]
Ref: M. E. Pasini, J. Intra, L. M. Gomulski, V. Calvenzani, K. Petroni, F. Briani and M. E. Perotti (2011) Identification and expression profiling of Ceratitis capitata genes coding for beta-hexosaminidases. Gene 473(1): 44-56. PMID: [21094225]
Function
 
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Subcellular Location
 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005886 C:plasma membrane IDA:FlyBase.
GO:0016231 F:beta-N-acetylglucosaminidase activity IDA:FlyBase.
GO:0043169 F:cation binding IEA:InterPro.
GO:0005975 P:carbohydrate metabolic process IEA:InterPro.
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Interpro
IPR025705;    Beta_hexosaminidase_sua/sub.
IPR015883;    Glyco_hydro_20_cat-core.
IPR015882;    Glyco_hydro_20b.
IPR013781;    Glyco_hydro_catalytic_dom.
IPR017853;    Glycoside_hydrolase_SF.
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Pfam
PF00728;    Glyco_hydro_20;    1.
PF02838;    Glyco_hydro_20b;    1.
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SMART
PROSITE
PRINTS
PR00738;    GLHYDRLASE20.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
Nucleotide Sequence
Length: bp   Go to nucleotide: FASTA
Protein Sequence
Length: 606 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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