SG ID

SG00000096 

UniProt Accession

F6U4V1_CIOIN;F6U4V1;  

Theoretical PI

5.54  

Molecular Weight

116064 Da  

Genbank Nucleotide ID

EAAA01000262;  

Genbank Protein ID

 

Gene Name

Cin.25122 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Uncharacterized protein 

Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) 

7719 

Temporarily unavailable 

The information of related literatures

1. N. Yokota, Y. Harada and H. Sawada (2010) Identification of testis-specific ubiquitin-conjugating enzyme in the ascidian Ciona intestinalis. Mol Reprod Dev 77(7): 640-7. 

Abstract
The ubiquitin-proteasome system is known to play a key role in fertilization in ascidians, sea urchins, and mammals. To obtain insights into the ubiquitin-conjugating enzymes (Ube2) involved in reproductive systems, we systematically explored Ube2 enzymes expressed in the testis of the ascidian Ciona intestinalis. Here, we report cDNA cloning and characterization of a novel type of Ube2r (Ci0100152677) that is capable of making a thiolester bond with ubiquitin. Northern analysis, whole-mount in situ hybridization and immunocytochemistry indicate that this enzyme is exclusively expressed in the testis, mainly in the germ cells during the late stage of spermatogenesis, and is localized in the sperm head and tail, suggesting possible participation in fertilization or spermatogenesis/spermiogenesis. PMID: [20578064] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005524	F:ATP binding	IEA:UniProtKB-KW.
GO:0016874	F:ligase activity	IEA:UniProtKB-KW.
GO:0008641	F:small protein activating enzyme activity	IEA:InterPro.
GO:0006464	P:cellular protein modification process	IEA:InterPro.

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Interpro

IPR009036;    Molybdenum_cofac_synth_MoeB.
IPR016040;    NAD(P)-bd_dom.
IPR000594;    ThiF_NAD_FAD-bd.
IPR018965;    Ub-activating_enz_e1_C.
IPR023280;    Ub-like_act_enz_cat_cys_dom.
IPR000127;    UBact_repeat.
IPR019572;    Ubiquitin-activating_enzyme.
IPR018075;    UBQ-activ_enz_E1.
IPR018074;    UBQ-activ_enz_E1_AS.
IPR000011;    UBQ/SUMO-activ_enz_E1-like.
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Pfam

PF00899;    ThiF;    2.
PF09358;    UBA_e1_C;    1.
PF10585;    UBA_e1_thiolCys;    1.
PF02134;    UBACT;    2.
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SMART

SM00985;    UBA_e1_C;    1.
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PROSITE

PS00536;    UBIQUITIN_ACTIVAT_1;    1.
PS00865;    UBIQUITIN_ACTIVAT_2;    1.
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PRINTS

PR01849;    UBIQUITINACT.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 1036 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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