SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000124 
UniProt Accession
Theoretical PI
8.99  
Molecular Weight
57409 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
dsx 
Gene Synonyms/Alias
ORFNames=CG11094 
Protein Name
Protein doublesex 
Protein Synonyms/Alias
 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:3R;3750045-3793130;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. L. U. Hempel and B. Oliver (2007) Sex-specific DoublesexM expression in subsets of Drosophila somatic gonad cells. BMC Dev Biol 7(): 113. 

Abstract
BACKGROUND PMID: [17935627] 

Back to Top
Figures for illustrating the function of this protein/gene
Ref: L. U. Hempel and B. Oliver (2007) Sex-specific DoublesexM expression in subsets of Drosophila somatic gonad cells. BMC Dev Biol 7(): 113. PMID: [17935627]
Ref: L. U. Hempel and B. Oliver (2007) Sex-specific DoublesexM expression in subsets of Drosophila somatic gonad cells. BMC Dev Biol 7(): 113. PMID: [17935627]
Ref: L. U. Hempel and B. Oliver (2007) Sex-specific DoublesexM expression in subsets of Drosophila somatic gonad cells. BMC Dev Biol 7(): 113. PMID: [17935627]
Ref: L. U. Hempel and B. Oliver (2007) Sex-specific DoublesexM expression in subsets of Drosophila somatic gonad cells. BMC Dev Biol 7(): 113. PMID: [17935627]
Ref: L. U. Hempel and B. Oliver (2007) Sex-specific DoublesexM expression in subsets of Drosophila somatic gonad cells. BMC Dev Biol 7(): 113. PMID: [17935627]
Ref: L. U. Hempel and B. Oliver (2007) Sex-specific DoublesexM expression in subsets of Drosophila somatic gonad cells. BMC Dev Biol 7(): 113. PMID: [17935627]
Ref: L. U. Hempel and B. Oliver (2007) Sex-specific DoublesexM expression in subsets of Drosophila somatic gonad cells. BMC Dev Biol 7(): 113. PMID: [17935627]
Function
Controls somatic sexual differentiation. Binds directlyand specifically to the FBE (fat body enhancer) of the yolkprotein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficientto direct the female-specific transcription characteristic of theYp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body. 
Back to Top
Subcellular Location
Nucleus. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005634 C:nucleus IEA:UniProtKB-SubCell.
GO:0003677 F:DNA binding TAS:FlyBase.
GO:0046872 F:metal ion binding IEA:UniProtKB-KW.
GO:0003729 F:mRNA binding NAS:FlyBase.
GO:0001078 F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA:FlyBase.
GO:0001077 F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA:FlyBase.
GO:0043565 F:sequence-specific DNA binding IEA:InterPro.
GO:0016199 P:axon midline choice point recognition IMP:FlyBase.
GO:0007417 P:central nervous system development TAS:FlyBase.
GO:0045497 P:female analia development NAS:FlyBase.
GO:0019101 P:female somatic sex determination NAS:FlyBase.
GO:0007483 P:genital disc morphogenesis TAS:FlyBase.
GO:0035263 P:genital disc sexually dimorphic development TAS:FlyBase.
GO:0007486 P:imaginal disc-derived female genitalia development IMP:FlyBase.
GO:0007485 P:imaginal disc-derived male genitalia development IGI:FlyBase.
GO:0045496 P:male analia development NAS:FlyBase.
GO:0045433 P:male courtship behavior, veined wing generated song production NAS:FlyBase.
GO:0046661 P:male sex differentiation TAS:FlyBase.
GO:0019102 P:male somatic sex determination NAS:FlyBase.
GO:0048086 P:negative regulation of developmental pigmentation TAS:FlyBase.
GO:0000398 P:nuclear mRNA splicing, via spliceosome TAS:FlyBase.
GO:0045570 P:regulation of imaginal disc growth TAS:FlyBase.
GO:0045498 P:sex comb development TAS:FlyBase.
GO:0048071 P:sex-specific pigmentation NAS:FlyBase.
GO:0007283 P:spermatogenesis NAS:FlyBase.
Back to Top
Interpro
IPR001275;    DM_DNA-bd.
IPR014932;    DSX_dimer.
Back to Top
Pfam
PF00751;    DM;    1.
PF08828;    DSX_dimer;    1.
Back to Top
SMART
SM00301;    DM;    1.
Back to Top
PROSITE
PS40000;    DM_1;    1.
PS50809;    DM_2;    1.
Back to Top
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    549       Protein doublesex.
                             /FTId=PRO_0000207041.
DNA_BIND     44     91       DM.
COMPBIAS    119    224       His-rich.
COMPBIAS    267    296       Gly/Ser-rich.
VAR_SEQ     398    427       ARVEINRTVAQIYYNYYTPMALVNGAPMYL -> GQYVVNE
                             YSRQHNLNIYDGGELRNTTRQCG (in isoform
                             Female).
                             /FTId=VSP_001321.
VAR_SEQ     428    549       Missing (in isoform Female).
                             /FTId=VSP_001322.
MUTAGEN      47     47       C->A,H: Abolishes DNA-binding.
MUTAGEN      50     50       H->Y: Abolishes DNA-binding.
MUTAGEN      59     59       H->Y: Abolishes DNA-binding.
MUTAGEN      68     68       C->D,Y: Abolishes DNA-binding.
MUTAGEN      70     70       C->Y: Abolishes DNA-binding.
MUTAGEN      91     91       R->Q: Abolishes DNA-binding.
CONFLICT     53     53       K -> N (in Ref. 4; AAL25296).
HELIX        45     48
TURN         49     51
TURN         55     58
HELIX        60     62
TURN         64     67
HELIX        71     80
HELIX       354    366
HELIX       371    373
HELIX       374    383
TURN        384    386
HELIX       388    397
Back to Top
Nucleotide Sequence
Length: 2447 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 549 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
dlDIP 
CG6996BioGRID 
ATPsyn-betaBioGRID 
tamoBioGRID 
TspBioGRID 
CG5180BioGRID 
dl-RCBioGRID 
tsg-RABioGRID 
dlBioGRID 
dsxIntAct 
dsxIntAct 
dlBioGRID 
PpnBioGRID 
PpnBioGRID 
RpS15AaBioGRID 
LanB1BioGRID 
ixBioGRID 
Mst84DaBioGRID 
Mst84DcBioGRID 
Mst84DdBioGRID 
PpnBioGRID 
CG15602BioGRID 
traBioGRID 
Trim9BioGRID 
ATPsyn-betaBioGRID 
CG31626BioGRID 
CG17377BioGRID 
CG17666BioGRID 
CG6933-RABioGRID 
CG13492BioGRID 
CG6933BioGRID 
lawcBioGRID 
CG4282BioGRID 
TspBioGRID 
haleBioGRID 
CG31740BioGRID 
CG5180BioGRID 
slowBioGRID 
CG17377BioGRID 
CG10323BioGRID 
Vha100-2BioGRID 
CG15170BioGRID 
CG34168-RABioGRID 
nimC1BioGRID 
ESTS:172F5TBioGRID 
CG17377BioGRID 
CG17376BioGRID 
CG17376BioGRID 
TspBioGRID 
CG7159BioGRID 
CG13311BioGRID 
CG17666BioGRID 
CG6996BioGRID 
CG6933-RCBioGRID 
C901BioGRID 
CG4363BioGRID 
CG13492BioGRID 
cvBioGRID 
RpS15AaBioGRID 
CG12592BioGRID 
tamoBioGRID 
traBioGRID 
tsgBioGRID 
Usp7BioGRID 
uzipBioGRID 
CasBioGRID 
ixBioGRID 
traBioGRID 
parkBioGRID 
p53BioGRID 
p53BioGRID 
CG10032BioGRID 
traBioGRID 
uzipDIP 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
Comments