SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000134 
UniProt Accession
Theoretical PI
4.96  
Molecular Weight
67171 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
mod(mdg4) 
Gene Synonyms/Alias
bpd, doom, E(var)3-93D 
Protein Name
Modifier of mdg4 
Protein Synonyms/Alias
 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:3R;17177331-17203121;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. M. Soltani-Bejnood, S. E. Thomas, L. Villeneuve, K. Schwartz, C. S. Hong and B. D. McKee (2007) Role of the mod(mdg4) common region in homolog segregation in Drosophila male meiosis. Genetics 176(1): 161-80. 

Abstract
Homologous chromosomes must pair and establish stable connections during prophase I of meiosis to segregate reliably from each other at anaphase I. In most organisms, the stable connections, called chiasmata, arise from crossovers. In Drosophila males, homologs pair and segregate without crossing over. Chiasmata are replaced by a homolog conjunction complex that includes the Stromalin in Meiosis (SNM) and Modifier of Mdg4 in Meiosis (MNM) proteins. MNM is one of 31 alternative splice products of mod(mdg4), all of which share a common 402-amino-acid N terminus and differ at their C termini. Previous data demonstrated that an MNM-specific exon is required for homolog conjunction, but did not address whether the N-terminal common region, which includes a BTB domain that can mediate coalescence of protein-DNA complexes, is also required. Here we describe a mutation in the common region of mod(mdg4), Z3-3401, that causes qualitatively similar phenotypes as the MNM-specific alleles but disrupts X-Y segregation much more drastically than autosomal segregation. The mutant MNM protein in Z3-3401 is expressed throughout prophase I in spermatocytes but the protein is confined to the cytoplasm, suggesting that the Z3-3401 mutation disrupts a signal required for nuclear localization or retention. Z3-3401 fails to complement a large battery of lethal and semilethal alleles in the common region for meiotic nondisjunction, including an allele containing an amino acid substitution at a conserved residue in the BTB/POZ domain, consistent with a general requirement for the mod(mdg4) common region in homolog segregation. PMID: [17277376] 

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Figures for illustrating the function of this protein/gene
Function
Component of the gypsy chromatin insulator complex whichis required for the function of the gypsy chromatin insulator andother endogenous chromatin insulators. Chromatin insulators areregulatory elements which establish independent domains oftranscriptional activity within eukaryotic genomes. Insulatorshave two defining properties; they can block the communicationbetween an enhancer and a promoter when placed between them andcan also buffer transgenes from position effect variegation (PEV).Insulators are proposed to structure the chromatin fiber intoindependent domains of differing transcriptional potential bypromoting the formation of distinct chromatin loops. Thischromatin looping may involve the formation of insulator bodies,where homotypic interactions between individual subunits of theinsulator complex could promote the clustering of widely spacedinsulators at the nuclear periphery. Within the gypsy insulatorcomplex, this protein may control the nature of the repressiveeffect of su(Hw): in the absence of mod(mdg4) protein, su(Hw)exerts a bidirectional silencing effect, whereas in the presenceof mod(mdg4), the silencing effect is unidirectional. Isoform H isspecifically required to maintain the pairing of achiasmatehomologs in male meiosis I which is mediated by the rDNA repeatson the achiasmate X-Y bivalents. Isoform H also plays a role inapoptotic regulatory pathways. 
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Subcellular Location
Nucleus. Chromosome. Note=Colocalizes withother elements of the gypsy chromatin insulator complex atmultiple sites on polytene chromosomes and at nuclear insulatorbodies. The unique C-termini of individual isoforms may specifybinding to particular chromosomal locations. During the G2 phaseof male meiosis isoform H localizes to the nucleolus. Itsubsequently localizes to the rDNA repeats of the X-Y bivalent andto multiple autosomal loci, where it remains until anaphase I.Localization to the rDNA repeats requires SA-2, while localizationto autosomal loci requires SA-2 and tef. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0000785 C:chromatin IMP:UniProtKB.
GO:0005634 C:nucleus IDA:FlyBase.
GO:0005886 C:plasma membrane ISS:FlyBase.
GO:0005700 C:polytene chromosome IDA:FlyBase.
GO:0003682 F:chromatin binding IMP:UniProtKB.
GO:0046872 F:metal ion binding IEA:UniProtKB-KW.
GO:0008195 F:phosphatidate phosphatase activity ISS:FlyBase.
GO:0006915 P:apoptotic process IEA:UniProtKB-KW.
GO:0016568 P:chromatin modification IEA:UniProtKB-KW.
GO:0008354 P:germ cell migration IMP:FlyBase.
GO:0006917 P:induction of apoptosis IMP:UniProtKB.
GO:0007060 P:male meiosis chromosome segregation IMP:FlyBase.
GO:0007141 P:male meiosis I IMP:FlyBase.
GO:0006997 P:nucleus organization TAS:FlyBase.
GO:0048477 P:oogenesis IMP:FlyBase.
GO:0001672 P:regulation of chromatin assembly or disassembly IMP:UniProtKB.
GO:0006355 P:regulation of transcription, DNA-dependent IEA:UniProtKB-KW.
GO:0006351 P:transcription, DNA-dependent IEA:UniProtKB-KW.
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Interpro
IPR000210;    BTB/POZ-like.
IPR011333;    BTB/POZ_fold.
IPR013069;    BTB_POZ.
IPR007588;    Znf_FLYWCH.
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Pfam
PF00651;    BTB;    1.
PF04500;    FLYWCH;    1.
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SMART
SM00225;    BTB;    1.
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PROSITE
PS50097;    BTB;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    610       Modifier of mdg4.
                             /FTId=PRO_0000096505.
DOMAIN       32     98       BTB.
ZN_FING     452    512       FLYWCH-type.
REGION        1    308       Interaction with Chi.
REGION        1    160       Self-association.
REGION      551    610       Interaction with su(Hw).
COMPBIAS    139    209       Gln-rich.
MOD_RES     230    230       Phosphoserine.
VAR_SEQ     360    449       Missing (in isoform mod1.9).
                             /FTId=VSP_010283.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> GDATQFFFTKGQRESVKLNYCGHSYVKFMENGRG
                             TKWICATRSTTKCRARIRTTKNNYLEVLYASHNHGFPPQKK
                             DRGRASQRM (in isoform 53.1).
                             /FTId=VSP_050724.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> EQEDDFKLHLPLLVTRRKKTPGGSRKQSFDHLEV
                             SFTRSNRGNNLLTIDGKPFTLNRRIKDVCYWECVKLRCKYI
                             KCSARVVTKSNRISALSGLHNHP (in isoform
                             54.7).
                             /FTId=VSP_010287.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> GHLSTLRHLPVEAIFDADGKQMDFIPNIRVIRSQ
                             RKTIKLMFKKYAYSKTNEHDTTTYWHCRSRRNGRPACKARF
                             STKKLKNGSYKVYLTQPEHNHPPKKRRL (in isoform
                             55.6).
                             /FTId=VSP_050725.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> VTQHVRNCGPQMFLISRKGGTLLTINNFVYRSNL
                             KFFGKSNNILYWECVQNRSVKCRSRLKTIGDDLYVTNDVHN
                             HMGDNKRIEAAKAAGMLIHKKLSSLTAADKIQGSWKMDTEG
                             NPDHLPKM (in isoform 59.0).
                             /FTId=VSP_010288.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> ESSVAIYSATSRGRMQLIYGGQPFIFEKTLKLSS
                             GEEKRFWRCNQWWNQKCRSRVFTINDVVCPLNRFHTHEEIV
                             RRKKRVRRVPPVETIAKVVATTPRHPQHQQTTQQQQEIQLT
                             SDAIAGAILDDESPATIDVSELGMHLKYEEIVADVTGIVGG
                             TRVVSRRK (in isoform 62.3).
                             /FTId=VSP_050701.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> EKQFEYVVSQKGHVLLLHKKFPFIREKCINGKTY
                             WRCTQYTTKTKCHGRLHVLNGKIVHIKTHNHSPLDQERKQY
                             MKLQLNNV (in isoform A).
                             /FTId=VSP_050713.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> VLTYDDRGKLVHEGFTFSCYSRNPGKCLAFWRCS
                             MYKKMHCTSALTTHIKSIKSIRGFHNHKPPERLKTFVPRVL
                             DCPPRPHKEDY (in isoform AA).
                             /FTId=VSP_034704.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> GVIQSLKALFEGKTTGASIQYTTTQRGRVMLVYE
                             GYRYVVNRQSLKNVFWRCSRYVKHSCRATLVTSKVQEVTLR
                             IAGTPHTHAPEVSSMDLTTDLLDEFPELQ (in isoform
                             AB).
                             /FTId=VSP_034705.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> VTFDVLTDPIVKPDQHQLMKRVRLSKSMEGVHYV
                             RTPAGNVVLHCGEHRYLRNAAYKDKVYWKCSKWRKQCRSRV
                             ITHILPNGQSRYAVSGVHNHP (in isoform B).
                             /FTId=VSP_010284.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> DGPSKDTAIPKPAEHPRKPVTDSVQKSPRDADAI
                             PLFDGSRVFVSKVALAKAYIPMPMIYTCRVMDLVIGKDKLV
                             RIAQHEETTDKDLIQDIITHVCKVFALRGNQLTPSAVQEFI
                             DHKLSTLKLMPIKEGK (in isoform C).
                             /FTId=VSP_050714.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> EFDYGHGQYRGNNPQIQFSVSKRGGQLLWLDGMK
                             FFRNNINRTNLYWRCHWYYRHTKCPVLICMSKTNSNDFRQI
                             HDHCHIRPKRKENSGTGDGPKIRTPVVSNVRSLPQSMAHMF
                             DM (in isoform D).
                             /FTId=VSP_010285.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> VKIKMEPSPTPGHSSDAAVAALAVTYLSDEESFR
                             KPFTLPKLLDGKFYKNIQPNQKTPGAIQATCTTCHGLISGT
                             TKSTGNFLSHIKRRHKELLPLCQLYCQAKANGTVPAVKSSP
                             PNPNHVLTSATPTPAMEMMTQVAQMPPTAAYATGPTHLGMP
                             VTVPVPVSMSLAMPISLPHVQTPQMMALMQQHQAHGAVFIS
                             KDY (in isoform E).
                             /FTId=VSP_050699.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> VVLANDEVPNPEDVLVFFTQSLRGRPAIMANGIR
                             FLIMSENKKKILWRCSSMATKKLKCPARITMLKETPPKFII
                             NKAEHLHAELKRNKYSSSKAQTLRDPHQMATKLDCEMEGAG
                             GVSFDLHEEELNELTHDV (in isoform F).
                             /FTId=VSP_050704.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> ELAVFGTGQRGRTVLLFQNEKFVKNRCSASRTYW
                             ICSKKDVTVCRARVVTAVDKNSQERIIKCTYEHDHSRKFPS
                             NNVNLPVLIKREKALSLDAS (in isoform G).
                             /FTId=VSP_050715.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> DLGELNPSNLADFGNESFLPKTKGKRPQNVRCGL
                             APDQKCVRTLDDWDRIRYDRTRSGDVLVYDGYRYDRRANYN
                             DIIYWGCAKKRLSCNVYMITHKNKPTYVAISGVHNHL (in
                             isoform H).
                             /FTId=VSP_050716.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> VCDDLDDMKGAIKHSLLTFIRGQRGCKLLAFNGH
                             NYVRNRRSNLKTYWICSKKGSTKCNARVVTNVVEGVHKIVL
                             ESCHHTCLNTERKKRLSVTNVVGKARSKSEKSVSTGFIKEE
                             GDEDLTLELRTLNLSIEDLNNLQ (in isoform I).
                             /FTId=VSP_050703.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> GSVAYYSYITGFRGSRKLKIGEFSFTRNKTSGLK
                             TYWSCARAGVHKCKARVVTAQDHDVTIKCGQHNHPPY (in
                             isoform J).
                             /FTId=VSP_050717.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> GQFIGDIPRGQWIDKHEYFFLKNQKQGFNLVFNG
                             YMYKKEASFRATVNWICSDGNGKRLNENKCSARAITKFDGG
                             IKLGKNAHNHPPRFLGGKVPAKLMPKDAFYPQY (in
                             isoform K).
                             /FTId=VSP_050718.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> DRKRYSKKFLNFDGPAEFSLAAHRRPRLIIANKH
                             FIVHRILGKDNLIGSWRCMYHHKGCKARATTFMVDSEVKYR
                             STCSSHNHKNVRSQQQSLKMPWVFTD (in isoform
                             M).
                             /FTId=VSP_050720.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> DTEISFIRSQKKNAQLVFRNYIYNKKLTQANGQT
                             TWRCADVLKLRCKAVVITRDGHFIDARRQHNHESHASRIGQ
                             RQLYKVEQELEEYIEICTSNPKISQYLGSSNIIVTAKDGKD
                             CKLFLPAAEATEIEMQALVDAAEEELDEEERHAEERIRDRQ
                             RVGRWRTEEAKHRSLLKSEHP (in isoform N).
                             /FTId=VSP_050700.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> EDELVFIESPWSTPCLVLNGYMYNCHSRKSNKQY
                             WRCHNYSKKAHEMRCRSRCVLENGRLKSVTGGLHNHQPHTE
                             KIDKIIQRNKMAAIGTGRKLSRTHSFTQLQLQEQKQEFIDE
                             HQLTSDAATLQLTDQELMHASMMLMHE (in isoform
                             O).
                             /FTId=VSP_050702.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> GCDGLQGSCRDRGGQKLTGANHQMHLRA (in
                             isoform Q).
                             /FTId=VSP_050721.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> GTSHLATFSCTRKKKRKLVIDRHEFVMDRKLKSS
                             INWRCARYRSSNCKVRATTHVQKNGLEVYRLKYAKHSHL
                             (in isoform R).
                             /FTId=VSP_050722.
VAR_SEQ     403    610       AATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLN
                             EEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCC
                             YREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQ
                             FMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFE
                             IQEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQN
                             KKK -> GLIFKAARHIAPIQKVRQVRDDKFLATIIKLEPA
                             GRLNLKNPDNIIRTSSNEHNFVYVGLPRMKGKCVNCLKKNR
                             TGLRRINTLCNTCPGSNWMCEPCFEELHS (in isoform
                             S).
                             /FTId=VSP_050723.
VAR_SEQ     404    610       ATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLNE
                             EASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCCY
                             REHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQF
                             MPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFEI
                             QEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQNK
                             KK -> CYQLVPNRRGGKNLIFQGHMYSVERKYRNSINWVC
                             SKNSNSVLRCPARCVTNPESGNGIKLSHRRHNHPADAFKPH
                             KRCRKRPGDRK (in isoform 53.6).
                             /FTId=VSP_010286.
VAR_SEQ     404    610       ATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLNE
                             EASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCCY
                             REHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQF
                             MPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFEI
                             QEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQNK
                             KK -> FHIDFADSKKNGGKLLVINGFRFFRNKKRGHLQYW
                             KCRNYYKERCPAIAIHDESTLILRLCHQHQHTESNDIEIKP
                             LPGSETKLAESAEDEAQAEPEAELDNETDPDTNHEPARVPP
                             LIMEPPPLLEIKSKLRNQDF (in isoform AC).
                             /FTId=VSP_034706.
VAR_SEQ     404    610       ATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLNE
                             EASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCCY
                             REHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQF
                             MPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFEI
                             QEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQNK
                             KK -> KDQNKGVLLKRTAQGEFLVVNGKSYKKTRAMQYRT
                             YFHCLTRNCPTYYVLVELSRRPRLTRHHEHAQHCLQCY
                             (in isoform L).
                             /FTId=VSP_050719.
VAR_SEQ     404    610       ATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAATLNE
                             EASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCCY
                             REHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSCLPSQF
                             MPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFEI
                             QEIDEIELDEPEKTPAKEEEVDPNDFREKIKRRLQKALQNK
                             KK -> KFDYQISVDVGEATMQLANASSAGVVNSNSPFFIV
                             SKYGTKQIMLKQHTFNRHICRDDVTYWRCSQFAVLRCRARL
                             KTKLDTLTILNSEHNHEVITKARKYGSLKRQRAEAEAAARA
                             ERRQDPLETAATSAPATTT (in isoform P).
                             /FTId=VSP_050705.
VAR_SEQ     459    610       GVKLIFNGHLFKFSFRKADYSVFQCCYREHGEECKVRVVCD
                             QKRVFPYEGEHVHFMQASDKSCLPSQFMPGESGVISSLSPS
                             KELLMKNTTKLEEADDKEDEDFEEFEIQEIDEIELDEPEKT
                             PAKEEEVDPNDFREKIKRRLQKALQNKKK -> DPTRPQLW
                             SSDVPDQPQATLLTINNFVYRANLKFFGKSNNILYWECVKT
                             DRLSAAVALKTIGDDLYVTNGSYSAVSKCKGHLMASFHLQM
                             CTITWATTSVLRRPRRLDADPQEVEFPHSRRQNPGFLENGH
                             RGQPRPSAQDVAASILPTQTFVFC (in isoform
                             mod1.8).
                             /FTId=VSP_010289.
MUTAGEN      33     33       D->N: In allele mod(mdg4)351; embryonic
                             lethal; when associated with S-92.
MUTAGEN      92     92       G->S: In allele mod(mdg4)351; embryonic
                             lethal; when associated with N-33.
CONFLICT    151    152       QQ -> HE (in Ref. 2; AAA82988/AAA82989/
                             AAA82990 and 3; AAC17459).
CONFLICT    466    466       G -> V (in Ref. 9; AAL33875).
CONFLICT    507    507       E -> K (in Ref. 1; CAA53216 and 4;
                             CAB85487).
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Nucleotide Sequence
Length: 1757 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 610 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
CycEBioGRID 
TrlBioGRID 
TrlBioGRID 
Cda5BioGRID 
CG12645BioGRID 
ash1BioGRID 
scBioGRID 
CG4692IntAct 
CG12607BioGRID 
CG3011BioGRID 
ctBioGRID 
CG11138BioGRID 
brmBioGRID 
Zasp52BioGRID 
Hsp70Ba-RABioGRID 
CycEBioGRID 
Cp190IntAct 
ctBioGRID 
GldBioGRID 
HLHm7MINT 
TrlBioGRID 
Su(var)205BioGRID 
Hsp70AaBioGRID 
Hsp70AbBioGRID 
Hsp70BaBioGRID 
Hsp70BbBioGRID 
Hsp70BbbBioGRID 
Hsp70BcBioGRID 
Su(var)3-9BioGRID 
lzBioGRID 
magoMINT 
CG8854BioGRID 
CycEBioGRID 
TrlBioGRID 
TrlBioGRID 
cherBioGRID 
ash1BioGRID 
scBioGRID 
CG4692BioGRID 
cherBioGRID 
ctBioGRID 
brmBioGRID 
CycEBioGRID 
ctBioGRID 
GldMINT 
CG9572-RBBioGRID 
HLHm7BioGRID 
TrlBioGRID 
Hsp70AaMINT 
lzBioGRID 
magoBioGRID 
Npc2aBioGRID 
BxBioGRID 
Rpn3MINT 
lzBioGRID 
TrlBioGRID 
TrlBioGRID 
CG8569BioGRID 
cherBioGRID 
CG11097IntAct 
BxBioGRID 
ctBioGRID 
cherBioGRID 
krzMINT 
_MINT 
_MINT 
_MINT 
_MINT 
CG15529MINT 
cherBioGRID 
Tango9MINT 
CG6415BioGRID 
CG7202BioGRID 
Cda5MINT 
Cpr72EaBioGRID 
CG11164MINT 
CG11138MINT 
yellow-d2BioGRID 
_MINT 
CG10527IntAct 
CG12645MINT 
CG3011MINT 
CG9572-RABioGRID 
Src64BBioGRID 
su(Hw)BioGRID 
trxBioGRID 
CG16817MINT 
yBioGRID 
Npc2aIntAct 
_MINT 
BxBioGRID 
smt3MINT 
Rpn3BioGRID 
Cda5BioGRID 
lzBioGRID 
TrlBioGRID 
TrlBioGRID 
Su(var)3-9BioGRID 
CG8569IntAct 
CG10265-RBBioGRID 
SaraBioGRID 
CG32016BioGRID 
CG11097BioGRID 
BxBioGRID 
ctBioGRID 
CG12607BioGRID 
krzBioGRID 
CG32016BioGRID 
CG15529BioGRID 
cherIntAct 
Tango9BioGRID 
CG6415MINT 
CG7202MINT 
Cda5BioGRID 
Cda5BioGRID 
CG15356BioGRID 
Cpr72EaIntAct 
CG11164BioGRID 
CG11138BioGRID 
CG11138BioGRID 
yellow-d2MINT 
CG10527BioGRID 
CG12645BioGRID 
CG3011BioGRID 
CG9572-RAIntAct 
CG18271IntAct 
Src64BIntAct 
su(Hw)BioGRID 
Su(var)3-9BioGRID 
trxBioGRID 
ldsIntAct 
CG16817BioGRID 
yBioGRID 
Zasp52BioGRID 
Other Protein-Protein interaction resources
String database  
View Microarray data
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