SG ID

SG00000135 

UniProt Accession

ORD_DROME;Q24434;Q9W1S8;  

Theoretical PI

5.69  

Molecular Weight

55166 Da  

Genbank Nucleotide ID

X92840; AE013599;  

Genbank Protein ID

CAA63426.1; AAF46975.1; 

Gene Name

ord 

Gene Synonyms/Alias

ORFNames=CG3134 

Protein Name

Protein ORD 

Protein Synonyms/Alias

Orientation disrupter protein; 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. E. M. Balicky, M. W. Endres, C. Lai and S. E. Bickel (2002) Meiotic cohesion requires accumulation of ORD on chromosomes before condensation. Mol Biol Cell 13(11): 3890-900. 

Abstract
Cohesion between sister chromatids is a prerequisite for accurate chromosome segregation during mitosis and meiosis. To allow chromosome condensation during prophase, the connections that hold sister chromatids together must be maintained but still permit extensive chromatin compaction. In Drosophila, null mutations in the orientation disruptor (ord) gene lead to meiotic nondisjunction in males and females because cohesion is absent by the time that sister kinetochores make stable microtubule attachments. We provide evidence that ORD is concentrated within the extrachromosomal domains of the nuclei of Drosophila primary spermatocytes during early G2, but accumulates on the meiotic chromosomes by mid to late G2. Moreover, using fluorescence in situ hybridization to monitor cohesion directly, we show that cohesion defects first become detectable in ord(null) spermatocytes shortly after the time when wild-type ORD associates with the chromosomes. After condensation, ORD remains bound at the centromeres of wild-type spermatocytes and persists there until centromeric cohesion is released during anaphase II. Our results suggest that association of ORD with meiotic chromosomes during mid to late G2 is required to maintain sister-chromatid cohesion during prophase condensation and that retention of ORD at the centromeres after condensation ensures the maintenance of centromeric cohesion until anaphase II. PMID: [12429833] 

Figures for illustrating the function of this protein/gene

Function

Essential for proper maintenance of sister-chromatidcohesion in both male and female meiosis. Mutations in ord causepremature separation of the sister chromatids in meiosis I andrandom segregation in both meiotic divisions. Required for chiasmamaintenance in female meiosis. Mutations in ord reducerecombination in female meiosis. 

Subcellular Location

Nucleus. Chromosome. Chromosome, centromere.Note=In male meiosis it assembles onto chromosomes in late G2 ofthe meiotic cell cycle. It remains at the centromeres afterchromosome condensation, through the meiosis I division until theseparation of sister chromatids at anaphase II.-----------------------------------------------------------------------Copyrighted by the UniProt Consortium, see http://www.uniprot.org/termsDistributed under the Creative Commons Attribution-NoDerivs License----------------------------------------------------------------------- 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0000775	C:chromosome, centromeric region	IEA:UniProtKB-SubCell.
GO:0008278	C:cohesin complex	IDA:UniProtKB.
GO:0001674	C:female germ cell nucleus	IDA:UniProtKB.
GO:0001673	C:male germ cell nucleus	IDA:UniProtKB.
GO:0007066	P:female meiosis sister chromatid cohesion	IDA:UniProtKB.
GO:0007276	P:gamete generation	IMP:FlyBase.
GO:0007060	P:male meiosis chromosome segregation	IMP:FlyBase.
GO:0007065	P:male meiosis sister chromatid cohesion	IDA:UniProtKB.
GO:0007067	P:mitosis	IMP:FlyBase.

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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 2710 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 479 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt	Gene Symbol	Ref Databases
RING1_DROME	Sce	BioGRID
SGO1_DROME	mei-S332	BioGRID
RING1_DROME	Sce	BioGRID

Other Protein-Protein interaction resources

String database  

UniProt	Gene Symbol	Ref Databases
ATR_DROME	mei-41	String
AURKB_DROME	ial	String
CID_DROME	cid	String
COX5A_DROME	CoVa	String
DCLK_DROME	CG17528	String
DSH_DROME	dsh	String
DS_DROME	ds	String
ECO_DROME	eco	String
EXPA_DROME	ex	String
FAT_DROME	ft	String
FOJO_DROME	fj	String
FRIZ2_DROME	fz2	String
FRIZ_DROME	fz	String
HMIN_DROME	inv	String
MAM_DROME	mam	String
NCD_DROME	ncd	String
NIPB_DROME	Nipped-B	String
OR1A_DROME	Or1a	String
OR59B_DROME	Or59b	String
ATR_DROME	mei-41	String
AURKB_DROME	ial	String
CID_DROME	cid	String
COX5A_DROME	CoVa	String
DCLK_DROME	CG17528	String
DSH_DROME	dsh	String
DS_DROME	ds	String
ECO_DROME	eco	String
EXPA_DROME	ex	String
FAT_DROME	ft	String
FOJO_DROME	fj	String
FRIZ2_DROME	fz2	String
FRIZ_DROME	fz	String
HMIN_DROME	inv	String
MAM_DROME	mam	String
NCD_DROME	ncd	String
NIPB_DROME	Nipped-B	String
OR1A_DROME	Or1a	String
OR59B_DROME	Or59b	String
OSA_DROME	osa	String
PAL2_DROME	Pal	String
PC_DROME	Pc	String
PICA_DROME	lap	String
POLO_DROME	polo	String
PRIC1_DROME	pk	String
PTC_DROME	ptc	String
RL38_DROME	RpL38	String
ROR1_DROME	Ror	String
SAN_DROME	san	String
STAN_DROME	stan	String
SUB_DROME	sub	String
SUHW_DROME	su(Hw)	String
TRA1_DROME	Nipped-A	String
USH_DROME	ush	String
WNT5_DROME	Wnt5	String
XPF_DROME	mei-9	String
OSA_DROME	osa	String
PAL2_DROME	Pal	String
PC_DROME	Pc	String
PICA_DROME	lap	String
POLO_DROME	polo	String
PRIC1_DROME	pk	String
PTC_DROME	ptc	String
RL38_DROME	RpL38	String
ROR1_DROME	Ror	String
SAN_DROME	san	String
SGO1_DROME	mei-S332	String
STAN_DROME	stan	String
SUB_DROME	sub	String
SUHW_DROME	su(Hw)	String
TRA1_DROME	Nipped-A	String
USH_DROME	ush	String
WNT5_DROME	Wnt5	String
XPF_DROME	mei-9	String

View Microarray data

Temporarily unavailable 

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