SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000149 
UniProt Accession
Theoretical PI
8.77  
Molecular Weight
45025 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
so 
Gene Synonyms/Alias
ORFNames=CG11121 
Protein Name
Protein sine oculis 
Protein Synonyms/Alias
 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:2R;3306537-3322377;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. J. J. Fabrizio, M. Boyle and S. DiNardo (2003) A somatic role for eyes absent (eya) and sine oculis (so) in Drosophila spermatocyte development. Dev Biol 258(1): 117-28. 

Abstract
Interactions between the soma and the germline are a conserved feature of spermatogenesis throughout the animal kingdom. In this report, we find that the transcription factors eyes absent (eya) and sine oculis (so), previously shown to play major roles during eye development [Cell 91 (1997), 881] are each required in the somatic cyst cells of the testis for proper Drosophila spermatocyte development. eya mutant testes exhibit degenerating young spermatocytes. Mosaic analysis reveals a somatic requirement for both eya and so, in that neither gene is required in the germline for spermatocyte development. Immunolocalization analysis supports this somatic role, since both proteins are localized within cyst cell nuclei as spermatocytes differentiate from amplifying spermatogonia. Using antibodies against known cyst cell markers, we demonstrate that cysts of degenerating spermatocytes in eya mutant testes are encysted, ruling out a role for eya in cyst cell viability. Finally, we have uncovered a genetic interaction between eya and so in the testis, suggesting that, as in the eye, eya and so may form a transcription complex responsible for the activation of target genes involved in cyst cell differentiation and spermatocyte development. PMID: [12781687] 

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Figures for illustrating the function of this protein/gene
Ref: J. J. Fabrizio, M. Boyle and S. DiNardo (2003) A somatic role for eyes absent (eya) and sine oculis (so) in Drosophila spermatocyte development. Dev Biol 258(1): 117-28. PMID: [12781687]
Function
Required for visual system development. Maytranscriptionally regulate genes necessary for optic lobeinvagination and Bolwig's nerve formation. 
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Subcellular Location
Nucleus. 
Tissue Specificity
In developing embryos, expressed in the eyedisk epithelium, bolwig's organ and the optic lobe primordium atareas of invagination. In adults, present in photoreceptor cellsin the apical regions of the retina, and in optic lobes. 
Gene Ontology
GO IDGO termEvidence
GO:0005634 C:nucleus IEA:UniProtKB-SubCell.
GO:0003705 F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA:FlyBase.
GO:0043565 F:sequence-specific DNA binding IDA:FlyBase.
GO:0001746 P:Bolwig's organ morphogenesis IMP:FlyBase.
GO:0007623 P:circadian rhythm IGI:FlyBase.
GO:0001745 P:compound eye morphogenesis IMP:FlyBase.
GO:0009649 P:entrainment of circadian clock IMP:FlyBase.
GO:0007455 P:eye-antennal disc morphogenesis TAS:FlyBase.
GO:0008347 P:glial cell migration IMP:FlyBase.
GO:0001744 P:optic lobe placode formation IMP:FlyBase.
GO:0045944 P:positive regulation of transcription from RNA polymerase II promoter IDA:FlyBase.
GO:0035271 P:ring gland development IMP:FlyBase.
GO:0007283 P:spermatogenesis IMP:FlyBase.
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Interpro
IPR017970;    Homeobox_CS.
IPR001356;    Homeodomain.
IPR009057;    Homeodomain-like.
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Pfam
PF00046;    Homeobox;    1.
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SMART
SM00389;    HOX;    1.
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PROSITE
PS00027;    HOMEOBOX_1;    1.
PS50071;    HOMEOBOX_2;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    416       Protein sine oculis.
                             /FTId=PRO_0000049315.
DNA_BIND    218    277       Homeobox.
COMPBIAS     42     47       Poly-Asn.
COMPBIAS     52     55       Poly-Asn.
COMPBIAS     80     85       Poly-Gly.
COMPBIAS    307    317       Gln/His-rich (OPA repeat).
COMPBIAS    366    372       Poly-Gly.
COMPBIAS    375    379       Poly-Ala.
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Nucleotide Sequence
Length: 2800 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 416 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Gadd45BioGRID 
RhoGEF2IntAct 
abDIP 
CG5033IntAct 
CG33090IntAct 
ChcIntAct 
CkIIbetaIntAct 
dppBioGRID 
eyaBioGRID 
groIntAct 
eyBioGRID 
eyaIntAct 
abIntAct 
gishBioGRID 
eyBioGRID 
eyBioGRID 
eyBioGRID 
gishBioGRID 
CG7878IntAct 
gishBioGRID 
gishBioGRID 
gishBioGRID 
gishBioGRID 
CG10576BioGRID 
CG9083IntAct 
Pif1AIntAct 
SobpIntAct 
RpS27BioGRID 
CG6688-RAIntAct 
C15IntAct 
RhoGAP93BIntAct 
CG5466IntAct 
gishBioGRID 
CG17265IntAct 
CG15459IntAct 
CG10576BioGRID 
Rcd5IntAct 
RhoGEF2BioGRID 
RhoGEF2BioGRID 
CkIIbetaBioGRID 
abBioGRID 
AesIntAct 
CG5033BioGRID 
CG33090BioGRID 
ChcBioGRID 
CkIIbetaBioGRID 
dppBioGRID 
abBioGRID 
eyaBioGRID 
groBioGRID 
hhBioGRID 
_MINT 
eyBioGRID 
eyaMINT 
abMINT 
gishBioGRID 
eyBioGRID 
eyBioGRID 
eyBioGRID 
gishBioGRID 
CG7878BioGRID 
C15BioGRID 
CG9083BioGRID 
gishBioGRID 
gishBioGRID 
abBioGRID 
gishBioGRID 
gishBioGRID 
_MINT 
CG9083MINT 
Pif1AMINT 
SobpBioGRID 
_MINT 
_MINT 
RpS27MINT 
CG6688-RABioGRID 
C15MINT 
RhoGAP93BBioGRID 
CG5466BioGRID 
gishBioGRID 
_MINT 
CG5665IntAct 
CG17265BioGRID 
CG15459BioGRID 
CG10576MINT 
Rcd5BioGRID 
tshBioGRID 
CG1218BioGRID 
VhaAC39-1BioGRID 
CG1218IntAct 
VhaAC39-1IntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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