Tag Content
SG ID
SG00000150 
UniProt Accession
Theoretical PI
5.02  
Molecular Weight
23185 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Su(var)205 
Gene Synonyms/Alias
HP1 
Protein Name
Heterochromatin protein 1 
Protein Synonyms/Alias
HP1 Non-histone chromosomal protein C1A9 antigen; 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:2L;8209626-8211133;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. L. Fanti, G. Giovinazzo, M. Berloco and S. Pimpinelli (1998) The heterochromatin protein 1 prevents telomere fusions in Drosophila. Mol Cell 2(5): 527-38. 

Abstract
HP1 (Heterochromatin protein 1) is a conserved, non-histone chromosomal protein that is best known for its preferential binding to pericentric heterochromatin and its role in position effect variegation in Drosophila. Using immunolocalization, we show that HP1 is a constant feature of the telomeres of interphase polytene and mitotic chromosomes. This localization does not require the presence of telomeric retrotransposons, since HP1 is also detected at the ends of terminally deleted chromosomes that lack these elements. Importantly, larvae expressing reduced or mutant versions of HP1 exhibit aberrant chromosome associations and multiple telomeric fusions in neuroblast cells, imaginal disks, and male meiotic cells. Taken together, these results provide evidence that HP1 plays a functional role in mediating normal telomere behavior in Drosophila. PMID: [9844626] 

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Figures for illustrating the function of this protein/gene
Function
Structural component of heterochromatin, involved ingene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at'Lys-9', leading to epigenetic repression. 
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Subcellular Location
Nucleus. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005721 C:centromeric heterochromatin NAS:FlyBase.
GO:0000780 C:condensed nuclear chromosome, centromeric region IDA:FlyBase.
GO:0005720 C:nuclear heterochromatin IDA:FlyBase.
GO:0005704 C:polytene chromosome band IDA:FlyBase.
GO:0005701 C:polytene chromosome chromocenter IDA:FlyBase.
GO:0005703 C:polytene chromosome puff IDA:FlyBase.
GO:0035012 C:polytene chromosome, telomeric region IDA:FlyBase.
GO:0003682 F:chromatin binding IDA:FlyBase.
GO:0003729 F:mRNA binding NAS:FlyBase.
GO:0000182 F:rDNA binding IDA:FlyBase.
GO:0003696 F:satellite DNA binding IDA:FlyBase.
GO:0030702 P:chromatin silencing at centromere IMP:FlyBase.
GO:0044026 P:DNA hypermethylation IMP:FlyBase.
GO:0006343 P:establishment of chromatin silencing IMP:FlyBase.
GO:0034773 P:histone H4-K20 trimethylation IMP:FlyBase.
GO:0022008 P:neurogenesis IMP:FlyBase.
GO:0045893 P:positive regulation of transcription, DNA-dependent TAS:FlyBase.
GO:0042981 P:regulation of apoptotic process IMP:FlyBase.
GO:0031060 P:regulation of histone methylation IMP:FlyBase.
GO:0000723 P:telomere maintenance IMP:FlyBase.
GO:0006351 P:transcription, DNA-dependent IEA:UniProtKB-KW.
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Interpro
IPR017984;    Chromo_dom_subgr.
IPR023780;    Chromo_domain.
IPR000953;    Chromo_domain/shadow.
IPR008251;    Chromo_shadow_dom.
IPR016197;    Chromodomain-like.
IPR023779;    Chromodomain_CS.
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Pfam
PF00385;    Chromo;    1.
PF01393;    Chromo_shadow;    1.
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SMART
SM00298;    CHROMO;    2.
SM00300;    ChSh;    1.
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PROSITE
PS00598;    CHROMO_1;    1.
PS50013;    CHROMO_2;    2.
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PRINTS
PR00504;    CHROMODOMAIN.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    206       Heterochromatin protein 1.
                             /FTId=PRO_0000080197.
DOMAIN       24     82       Chromo 1.
DOMAIN      147    205       Chromo 2.
REGION       95    206       Binds to Su(var)39.
COMPBIAS     18     23       Poly-Glu.
BINDING      24     24       Histone H3K9me2.
BINDING      45     45       Histone H3K9me2.
BINDING      48     48       Histone H3K9me2.
MOD_RES      11     11       Phosphoserine.
MOD_RES      15     15       Phosphoserine.
MOD_RES     102    102       Phosphoserine.
MOD_RES     103    103       Phosphoserine.
MOD_RES     113    113       Phosphoserine.
MOD_RES     127    127       Phosphothreonine.
MOD_RES     128    128       Phosphothreonine.
MOD_RES     134    134       Phosphothreonine.
VARIANT     105    105       T -> A (in strain: NC322, NC358 and
                             NC359).
VARIANT     126    126       R -> C (in strain: NC390).
VARIANT     134    134       T -> S (in strain: MW25).
MUTAGEN      10     10       S->A: 3-fold lower H3 binding affinity.
MUTAGEN      26     26       V->M: Abolishes H3 binding.
STRAND       24     35
STRAND       38     45
HELIX        50     52
STRAND       54     57
HELIX        58     60
HELIX        64     73
TURN        142    146
STRAND      149    158
STRAND      161    168
STRAND      175    178
HELIX       179    185
HELIX       187    196
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Nucleotide Sequence
Length: 1592 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 206 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
CG15109BioGRID 
CG15109BioGRID 
rlBioGRID 
cavBioGRID 
Su(var)3-7BioGRID 
cav-REBioGRID 
rlBioGRID 
grkBioGRID 
His3MINT 
Su(var)2-HP2IntAct 
CG15109IntAct 
rlBioGRID 
Actr13EIntAct 
moiDIP 
mod(mdg4)-RDBioGRID 
cavIntAct 
CkIIalphaIntAct 
rlBioGRID 
grkIntAct 
His3IntAct 
Su(var)3-9BioGRID 
mod(mdg4)BioGRID 
_IntAct 
Orc1IntAct 
Orc2IntAct 
E(Pc)BioGRID 
Su(var)3-9BioGRID 
CG6564IntAct 
ltBioGRID 
ltBioGRID 
HP4IntAct 
ltBioGRID 
LhrIntAct 
CG15293IntAct 
CG7357IntAct 
AlhIntAct 
CG3680MINT 
rho-4IntAct 
HP5IntAct 
RpL22-likeBioGRID 
Su(var)3-7IntAct 
Su(var)3-9BioGRID 
wBioGRID 
Su(var)3-9BioGRID 
Mcm10IntAct 
_MINT 
eyBioGRID 
Mt2BioGRID 
E(Pc)BioGRID 
rho-4BioGRID 
Su(var)3-9BioGRID 
eyBioGRID 
eyBioGRID 
eyBioGRID 
CG6564BioGRID 
ltBioGRID 
ltBioGRID 
zBioGRID 
HP4BioGRID 
ltBioGRID 
LhrBioGRID 
HP5BioGRID 
CG15293BioGRID 
_MINT 
_MINT 
CG7357BioGRID 
Mt2BioGRID 
CG3680BioGRID 
HP4BioGRID 
rho-4BioGRID 
HP5BioGRID 
RpL22-likeIntAct 
eggBioGRID 
Su(var)3-7BioGRID 
Su(var)3-9BioGRID 
TRIM28BioGRID 
wBioGRID 
zBioGRID 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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