SG ID

SG00000156 

UniProt Accession

Q2PNN0_DROME;Q2PNN0;  

Theoretical PI

8.92  

Molecular Weight

62181 Da  

Genbank Nucleotide ID

DQ316029;  

Genbank Protein ID

ABC48776.1; 

Gene Name

aly 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Always early 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. J. Jiang and H. White-Cooper (2003) Transcriptional activation in Drosophila spermatogenesis involves the mutually dependent function of aly and a novel meiotic arrest gene cookie monster. Development 130(3): 563-73. 

Abstract
In Drosophila spermatogenesis, meiotic cell cycle progression and cellular differentiation are linked by the function of the meiotic arrest genes. The meiotic arrest genes control differentiation by regulating the transcriptional activation of many differentiation-specific genes. The meiotic arrest genes have been subdivided into aly and can classes, based on the mechanism by which they control cell cycle progression. aly has previously been shown to encode a chromatin-associated protein. We present the identification, cloning and characterisation of a novel Drosophila meiotic arrest gene, cookie monster (comr), that has a mutant phenotype indistinguishable from that of aly. A null mutant allele of comr is viable but male sterile. Mutant primary spermatocytes fail to initiate transcription of a large number of genes, and arrest before entry into the meiotic divisions. In adult males, expression of comr is testis specific, low levels of transcripts are detected at other stages of development. comr encodes a novel acidic protein, which is nuclear and primarily localised to regions of chromatin in primary spermatocytes. The nuclear localisation of Aly and Comr proteins are mutually dependent. Finally, we show that active RNA polymerase II is found in distinct domains in the nucleus that constitute a subset of the total Comr stained chromatin. PMID: [12490562] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005737	C:cytoplasm	IDA:FlyBase.
GO:0000790	C:nuclear chromatin	IDA:FlyBase.
GO:0006325	P:chromatin organization	NAS:FlyBase.
GO:0006352	P:DNA-dependent transcription, initiation	TAS:FlyBase.
GO:0007141	P:male meiosis I	IMP:FlyBase.
GO:0051039	P:positive regulation of transcription during meiosis	IMP:FlyBase.
GO:0045944	P:positive regulation of transcription from RNA polymerase II promoter	IMP:FlyBase.
GO:0007286	P:spermatid development	TAS:FlyBase.

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Interpro

IPR010561;    DIRP.
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Pfam

PF06584;    DIRP;    1.
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SMART

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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 534 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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