SG ID

SG00000250 

UniProt Accession

Q9VX20_DROME;Q9VX20;  

Theoretical PI

6.19  

Molecular Weight

42665 Da  

Genbank Nucleotide ID

AE014298; BT022139;  

Genbank Protein ID

AAF48763.2; AAY51534.1; 

Gene Name

OdsH 

Gene Synonyms/Alias

ORFNames=Dmel_CG6352 

Protein Name

 

Protein Synonyms/Alias

SubName: IP01524pSubName: Ods-site homeobox 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. S. Sun, C. T. Ting and C. I. Wu (2004) The normal function of a speciation gene, Odysseus, and its hybrid sterility effect. Science 305(5680): 81-3. 

Abstract
To understand how postmating isolation is connected to the normal process of species divergence and why hybrid male sterility is often the first sign of speciation, we analyzed the Odysseus (OdsH) gene of hybrid male sterility in Drosophila. We carried out expression analysis, transgenic study, and gene knockout. The combined evidence suggests that the sterility phenotype represents a novel manifestation of the gene function rather than the reduction or loss of the normal one. The gene knockout experiment identified the normal function of OdsH as a modest enhancement of sperm production in young males. The implication of a weak effect of OdsH on the normal phenotype but a strong influence on hybrid male sterility is discussed in light of Haldane's rule of postmating isolation. PMID: [15232104] 

2. J. J. Bayes and H. S. Malik (2009) Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling species. Science 326(5959): 1538-41. 

Abstract
Hybrid sterility of the heterogametic sex is one of the first postzygotic reproductive barriers to evolve during speciation, yet the molecular basis of hybrid sterility is poorly understood. We show that the hybrid male sterility gene Odysseus-site homeobox (OdsH) encodes a protein that localizes to evolutionarily dynamic loci within heterochromatin and leads to their decondensation. In Drosophila mauritiana x Drosophila simulans male hybrids, OdsH from D. mauritiana (OdsHmau) acts as a sterilizing factor by associating with the heterochromatic Y chromosome of D. simulans, whereas D. simulans OdsH (OdsHsim) does not. Characterization of sterile hybrid testes revealed that OdsH abundance and localization in the premeiotic phases of spermatogenesis differ between species. These results reveal that rapid heterochromatin evolution affects the onset of hybrid sterility. PMID: [19933102] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

Nucleus (By similarity).-----------------------------------------------------------------------Copyrighted by the UniProt Consortium, see http://www.uniprot.org/termsDistributed under the Creative Commons Attribution-NoDerivs License----------------------------------------------------------------------- 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005615	C:extracellular space	IDA:FlyBase.
GO:0005634	C:nucleus	IEA:UniProtKB-SubCell.
GO:0043565	F:sequence-specific DNA binding	IEA:InterPro.
GO:0003700	F:sequence-specific DNA binding transcription factor activity	IEA:InterPro.
GO:0032504	P:multicellular organism reproduction	IEP:FlyBase.

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Interpro

IPR017970;    Homeobox_CS.
IPR001356;    Homeodomain.
IPR009057;    Homeodomain-like.
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Pfam

PF00046;    Homeobox;    1.
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SMART

SM00389;    HOX;    1.
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PROSITE

PS00027;    HOMEOBOX_1;    1.
PS50071;    HOMEOBOX_2;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 382 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

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