SG ID

SG00000257 

UniProt Accession

Q8T9L0_DROME;Q8T9L0;  

Theoretical PI

7.37  

Molecular Weight

42389 Da  

Genbank Nucleotide ID

AY069246;  

Genbank Protein ID

AAL39391.1; 

Gene Name

Drp1 

Gene Synonyms/Alias

noodle 

Protein Name

 

Protein Synonyms/Alias

SubName: GM01975p 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. A. C. Aldridge, L. P. Benson, M. M. Siegenthaler, B. T. Whigham, R. S. Stowers and K. G. Hales (2007) Roles for Drp1, a dynamin-related protein, and milton, a kinesin-associated protein, in mitochondrial segregation, unfurling and elongation during Drosophila spermatogenesis. Fly (Austin) 1(1): 38-46. 

Abstract
Mitochondria undergo dramatic rearrangement during Drosophila spermatogenesis. In wild type testes, the many small mitochondria present in pre-meiotic spermatocytes later aggregate, fuse, and interwrap in post-meiotic haploid spermatids to form the spherical Nebenkern, whose two giant mitochondrial compartments later unfurl and elongate beside the growing flagellar axoneme. Drp1 encodes a dynamin-related protein whose homologs in many organisms mediate mitochondrial fission and whose Drosophila homolog is known to govern mitochondrial morphology in neurons. The milton gene encodes an adaptor protein that links mitochondria with kinesin and that is required for mitochondrial transport in Drosophila neurons. To determine the roles of Drp1 and Milton in spermatogenesis, we used the FLP-FRT mitotic recombination system to generate spermatocytes homozygous for mutations in either gene in an otherwise heterozygous background. We found that absence of Drp1 leads to abnormal clustering of mitochondria in mature primary spermatocytes and aberrant unfurling of the mitochondrial derivatives in early Drp1 spermatids undergoing axonemal elongation. In milton spermatocytes, mitochondria are distributed normally; however, after meiosis, the Nebenkern is not strongly anchored to the nucleus, and the mitochondrial derivatives do not elongate properly. Our work defines specific functions for Drp1 and Milton in the anchoring, unfurling, and elongation of mitochondria during sperm formation. PMID: [18690063] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005875	C:microtubule associated complex	IDA:FlyBase.
GO:0005525	F:GTP binding	IEA:InterPro.
GO:0003924	F:GTPase activity	IEA:InterPro.
GO:0000910	P:cytokinesis	IMP:FlyBase.
GO:0006184	P:GTP catabolic process	IEA:GOC.
GO:0051646	P:mitochondrion localization	IMP:FlyBase.
GO:0030382	P:sperm mitochondrion organization	IMP:FlyBase.
GO:0016185	P:synaptic vesicle budding from presynaptic membrane	NAS:FlyBase.

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Interpro

IPR000375;    Dynamin_central.
IPR003130;    GED.
IPR020850;    GTPase_effector_domain_GED.
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Pfam

PF01031;    Dynamin_M;    1.
PF02212;    GED;    1.
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SMART

SM00302;    GED;    1.
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PROSITE

PS51388;    GED;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 1630 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 371 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

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