SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000264 
UniProt Accession
Theoretical PI
8.5  
Molecular Weight
24305 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
slmo 
Gene Synonyms/Alias
kisir 
Protein Name
Protein slowmo 
Protein Synonyms/Alias
 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:2L;6046646-6048702;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. S. Reeve, A. Carhan, C. T. Dee and K. G. Moffat (2007) Slowmo is required for Drosophila germline proliferation. Genesis 45(2): 66-75. 

Abstract
Null mutations in the Drosophila gene, slowmo (slmo), result in reduced mobility and lethality in first-instar larvae. Slowmo encodes a mitochondrial protein of unknown function, as do the two other homologs found in Drosophila. Here, we have studied a hypomorphic P-element allele of slmo demonstrating its effects on germline divisions in both testes and ovaries. Using in situ studies, enhancer-trap activity, and promoter fusions, we have shown that slmo expression in testes is found in the somatic cyst cells (SCC). The hypomorphic allele for Slmo revealed apoptotic loss of germline cells in the larval germline, culminating in a complete absence of the germline in adult flies. In females, a similar degeneration of the germarium is observed, while reporter gene expression is found in both germline and somatic cells. Using a null mutation in female germline clones, we find slmo is dispensable from the germline cells. Our results suggest that Slowmo is not required in germline cells directly, but is required in SCCs responsible for maintaining germline survival in both sexes. PMID: [17245774] 

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Figures for illustrating the function of this protein/gene
Ref: S. Reeve, A. Carhan, C. T. Dee and K. G. Moffat (2007) Slowmo is required for Drosophila germline proliferation. Genesis 45(2): 66-75. PMID: [17245774]
Ref: S. Reeve, A. Carhan, C. T. Dee and K. G. Moffat (2007) Slowmo is required for Drosophila germline proliferation. Genesis 45(2): 66-75. PMID: [17245774]
Ref: S. Reeve, A. Carhan, C. T. Dee and K. G. Moffat (2007) Slowmo is required for Drosophila germline proliferation. Genesis 45(2): 66-75. PMID: [17245774]
Ref: S. Reeve, A. Carhan, C. T. Dee and K. G. Moffat (2007) Slowmo is required for Drosophila germline proliferation. Genesis 45(2): 66-75. PMID: [17245774]
Ref: S. Reeve, A. Carhan, C. T. Dee and K. G. Moffat (2007) Slowmo is required for Drosophila germline proliferation. Genesis 45(2): 66-75. PMID: [17245774]
Function
Required to regulate peristaltic movement and also forgermline proliferation in males and females. 
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Subcellular Location
Mitochondrion. 
Tissue Specificity
Expressed in specific tissues such as thedeveloping central nervous system (CNS) and both the male andfemale germline. In the CNS, it is restricted in a subset of cellsduring embryogenesis and early larval development. In embryos, itis also expressed in salivary glands. In the testis, expressed insomatic cyst cells throughout the distal region where the mitoticcysts develop, extending through to meiotic cysts. 
Gene Ontology
GO IDGO termEvidence
GO:0005739 C:mitochondrion IMP:UniProtKB.
GO:0030154 P:cell differentiation IEA:UniProtKB-KW.
GO:0008345 P:larval locomotory behavior IMP:UniProtKB.
GO:0007275 P:multicellular organismal development IEA:UniProtKB-KW.
GO:0048477 P:oogenesis IEA:UniProtKB-KW.
GO:0030432 P:peristalsis IMP:UniProtKB.
GO:0007283 P:spermatogenesis IEA:UniProtKB-KW.
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Interpro
IPR006797;    PRELI/MSF1.
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Pfam
PF04707;    PRELI;    1.
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SMART
PROSITE
PS50904;    PRELI_MSF1;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    215       Protein slowmo.
                             /FTId=PRO_0000071958.
DOMAIN        1    170       PRELI/MSF1.
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Nucleotide Sequence
Length: 1374 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 215 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
CG1120BioGRID 
CG1120IntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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