SG ID

SG00000290 

UniProt Accession

Q9W0D7_DROME;Q9W0D7;  

Theoretical PI

8.92  

Molecular Weight

34655 Da  

Genbank Nucleotide ID

AE014296; AY069290;  

Genbank Protein ID

AAF47512.1; AAL39435.1; 

Gene Name

pex10 

Gene Synonyms/Alias

ORFNames=CG7864, Dmel_CG7864 

Protein Name

 

Protein Synonyms/Alias

SubName: CG7864SubName: GM14467p 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. H. Chen, Z. Liu and X. Huang (2010) Drosophila models of peroxisomal biogenesis disorder. Hum Mol Genet 19(3): 494-505. 

Abstract
Peroxisomes are vital eukaryotic organelles that participate in lipid metabolism, in particular the metabolism of very-long-chain fatty acids (VLCFA). The biogenesis of peroxisomes is regulated by a set of peroxin proteins (PEX). In humans, mutations affecting peroxin protein production or function result in devastating diseases classified as peroxisome biogenesis disorders (PBD). The way in which peroxisomal dysfunction leads to the pathophysiological consequences of PBD is not well understood. Here we report that Drosophila pex mutants faithfully recapitulate several key features of human PBD, including impaired peroxisomal protein import, elevated VLCFA levels and growth retardation. Moreover, disruption of pex function results in spermatogenesis defects, including spermatocyte cytokinesis failure in Drosophila. Importantly, increased VLCFA levels enhance these spermatogenesis defects whereas reduced VLCFA levels alleviate them. Thus, regulation of proper VLCFA levels by pex genes is crucial for spermatogenesis. Together our study reveals an indispensable function of pex genes during spermatogenesis and provides a causative link between the phenotypic severity of pex mutants and VLCFA levels. PMID: [19933170] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005779	C:integral to peroxisomal membrane	IEA:InterPro.
GO:0008270	F:zinc ion binding	IEA:InterPro.
GO:0007112	P:male meiosis cytokinesis	IMP:FlyBase.
GO:0007285	P:primary spermatocyte growth	IMP:FlyBase.
GO:0016558	P:protein import into peroxisome matrix	IEA:InterPro.
GO:0007286	P:spermatid development	IMP:FlyBase.
GO:0048137	P:spermatocyte division	IMP:FlyBase.

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Interpro

IPR025654;    PEX10.
IPR006845;    Pex_N.
IPR001841;    Znf_RING.
IPR013083;    Znf_RING/FYVE/PHD.
IPR017907;    Znf_RING_CS.
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Pfam

PF04757;    Pex2_Pex12;    1.
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SMART

SM00184;    RING;    1.
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PROSITE

PS00518;    ZF_RING_1;    1.
PS50089;    ZF_RING_2;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 299 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt	Gene Symbol	Ref Databases
MNB_DROME	mnb	BioGRID
PEX12_DROME	CG3639	IntAct
Q9VX06_DROME	mnb	BioGRID
Q9VX06_DROME	mnb	IntAct

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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