SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000291 
UniProt Accession
Theoretical PI
FRAGMENT  
Molecular Weight
35273 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
pex2 
Gene Synonyms/Alias
ORFNames=CG7081 
Protein Name
 
Protein Synonyms/Alias
SubName: LD46714pFlags: Fragment 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:3L;8332153-8333376;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. H. Chen, Z. Liu and X. Huang (2010) Drosophila models of peroxisomal biogenesis disorder. Hum Mol Genet 19(3): 494-505. 

Abstract
Peroxisomes are vital eukaryotic organelles that participate in lipid metabolism, in particular the metabolism of very-long-chain fatty acids (VLCFA). The biogenesis of peroxisomes is regulated by a set of peroxin proteins (PEX). In humans, mutations affecting peroxin protein production or function result in devastating diseases classified as peroxisome biogenesis disorders (PBD). The way in which peroxisomal dysfunction leads to the pathophysiological consequences of PBD is not well understood. Here we report that Drosophila pex mutants faithfully recapitulate several key features of human PBD, including impaired peroxisomal protein import, elevated VLCFA levels and growth retardation. Moreover, disruption of pex function results in spermatogenesis defects, including spermatocyte cytokinesis failure in Drosophila. Importantly, increased VLCFA levels enhance these spermatogenesis defects whereas reduced VLCFA levels alleviate them. Thus, regulation of proper VLCFA levels by pex genes is crucial for spermatogenesis. Together our study reveals an indispensable function of pex genes during spermatogenesis and provides a causative link between the phenotypic severity of pex mutants and VLCFA levels. PMID: [19933170] 

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Figures for illustrating the function of this protein/gene
Ref: H. Chen, Z. Liu and X. Huang (2010) Drosophila models of peroxisomal biogenesis disorder. Hum Mol Genet 19(3): 494-505. PMID: [19933170]
Ref: H. Chen, Z. Liu and X. Huang (2010) Drosophila models of peroxisomal biogenesis disorder. Hum Mol Genet 19(3): 494-505. PMID: [19933170]
Ref: H. Chen, Z. Liu and X. Huang (2010) Drosophila models of peroxisomal biogenesis disorder. Hum Mol Genet 19(3): 494-505. PMID: [19933170]
Ref: H. Chen, Z. Liu and X. Huang (2010) Drosophila models of peroxisomal biogenesis disorder. Hum Mol Genet 19(3): 494-505. PMID: [19933170]
Ref: H. Chen, Z. Liu and X. Huang (2010) Drosophila models of peroxisomal biogenesis disorder. Hum Mol Genet 19(3): 494-505. PMID: [19933170]
Function
 
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Subcellular Location
 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0008270 F:zinc ion binding IEA:InterPro.
GO:0007112 P:male meiosis cytokinesis IMP:FlyBase.
GO:0007031 P:peroxisome organization IMP:FlyBase.
GO:0007285 P:primary spermatocyte growth IMP:FlyBase.
GO:0007286 P:spermatid development IMP:FlyBase.
GO:0048137 P:spermatocyte division IMP:FlyBase.
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Interpro
IPR006845;    Pex_N.
IPR001841;    Znf_RING.
IPR013083;    Znf_RING/FYVE/PHD.
IPR017907;    Znf_RING_CS.
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Pfam
PF04757;    Pex2_Pex12;    1.
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SMART
SM00184;    RING;    1.
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PROSITE
PS00518;    ZF_RING_1;    1.
PS50089;    ZF_RING_2;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
NON_TER       1      1
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Nucleotide Sequence
Length: 1041 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 306 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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