SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000306 
UniProt Accession
Theoretical PI
6.3  
Molecular Weight
55565 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
p53 
Gene Synonyms/Alias
ORFNames=Dmel_CG33336 
Protein Name
 
Protein Synonyms/Alias
SubName: P53 protein long form variant 1SubName: p53, isoform B 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:3R;18875379-18879804;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. W. J. Lu, J. Chapo, I. Roig and J. M. Abrams (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328(5983): 1278-81. 

Abstract
The evolutionary appearance of p53 protein probably preceded its role in tumor suppression, suggesting that there may be unappreciated functions for this protein. Using genetic reporters as proxies to follow in vivo activation of the p53 network in Drosophila, we discovered that the process of meiotic recombination instigates programmed activation of p53 in the germ line. Specifically, double-stranded breaks in DNA generated by the topoisomerase Spo11 provoked functional p53 activity, which was prolonged in cells defective for meiotic DNA repair. This intrinsic stimulus for the p53 regulatory network is highly conserved because Spo11-dependent activation of p53 also occurs in mice. Our findings establish a physiological role for p53 in meiosis and suggest that tumor-suppressive functions may have been co-opted from primordial activities linked to recombination. PMID: [20522776] 

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Figures for illustrating the function of this protein/gene
Ref: W. J. Lu, J. Chapo, I. Roig and J. M. Abrams (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328(5983): 1278-81. PMID: [20522776]
Ref: W. J. Lu, J. Chapo, I. Roig and J. M. Abrams (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328(5983): 1278-81. PMID: [20522776]
Function
 
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Subcellular Location
 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0000785 C:chromatin IBA:RefGenome.
GO:0005829 C:cytosol IBA:RefGenome.
GO:0005667 C:transcription factor complex IBA:RefGenome.
GO:0003682 F:chromatin binding IBA:RefGenome.
GO:0003684 F:damaged DNA binding IBA:RefGenome.
GO:0003690 F:double-stranded DNA binding IBA:RefGenome.
GO:0043565 F:sequence-specific DNA binding IBA:RefGenome.
GO:0003700 F:sequence-specific DNA binding transcription factor activity IBA:RefGenome.
GO:0044212 F:transcription regulatory region DNA binding IEA:InterPro.
GO:0006919 P:activation of cysteine-type endopeptidase activity involved in apoptotic process IMP:FlyBase.
GO:0071480 P:cellular response to gamma radiation IMP:BHF-UCL.
GO:0034644 P:cellular response to UV IBA:RefGenome.
GO:0008340 P:determination of adult lifespan IMP:FlyBase.
GO:0042771 P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis IMP:BHF-UCL.
GO:0006978 P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA:RefGenome.
GO:0035234 P:germ cell programmed cell death IMP:FlyBase.
GO:0031558 P:induction of apoptosis in response to chemical stimulus IGI:BHF-UCL.
GO:0031571 P:mitotic cell cycle G1/S transition DNA damage checkpoint IBA:RefGenome.
GO:0046533 P:negative regulation of photoreceptor cell differentiation IMP:FlyBase.
GO:0000122 P:negative regulation of transcription from RNA polymerase II promoter IBA:RefGenome.
GO:0048477 P:oogenesis IGI:FlyBase.
GO:0045787 P:positive regulation of cell cycle IGI:FlyBase.
GO:0045944 P:positive regulation of transcription from RNA polymerase II promoter IMP:BHF-UCL.
GO:0007131 P:reciprocal meiotic recombination IMP:FlyBase.
GO:0042127 P:regulation of cell proliferation IMP:FlyBase.
GO:0043523 P:regulation of neuron apoptotic process IBA:RefGenome.
GO:0046620 P:regulation of organ growth IMP:FlyBase.
GO:0010165 P:response to X-ray IBA:RefGenome.
GO:0042246 P:tissue regeneration IMP:FlyBase.
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Interpro
IPR008967;    p53-like_TF_DNA-bd.
IPR012346;    p53/RUNT-type_TF_DNA-bd.
IPR024631;    p53_C_Drosophila.
IPR011615;    p53_DNA-bd.
IPR002117;    p53_tumour_suppressor.
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Pfam
PF00870;    P53;    1.
PF11619;    P53_C;    1.
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SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
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Nucleotide Sequence
Length: 27905053 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 495 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
lokBioGRID 
hayBioGRID 
hayBioGRID 
lokBioGRID 
MED26IntAct 
fasIntAct 
Myt1BioGRID 
PofIntAct 
MEP-1IntAct 
wdeIntAct 
140upBioGRID 
gusBioGRID 
gusBioGRID 
gusBioGRID 
gusBioGRID 
touBioGRID 
Vha36-2BioGRID 
fasBioGRID 
CG8102BioGRID 
CG8102BioGRID 
CG13436BioGRID 
mu2BioGRID 
lokBioGRID 
Nipped-ABioGRID 
touBioGRID 
mrjBioGRID 
aubBioGRID 
CG11486BioGRID 
wocBioGRID 
Act57BBioGRID 
FdhBioGRID 
AGO2BioGRID 
apBioGRID 
asf1BioGRID 
aspBioGRID 
CG8783-RABioGRID 
cenG1A-RCBioGRID 
CG42389BioGRID 
hayBioGRID 
CG42232BioGRID 
simaBioGRID 
bcdBioGRID 
CG9383BioGRID 
Cyp6a22BioGRID 
spn-A-RABioGRID 
Act57B-RABioGRID 
cenG1ABioGRID 
chbBioGRID 
cortBioGRID 
Cyp6d5BioGRID 
dimmBioGRID 
dsxBioGRID 
Act57BBioGRID 
apBioGRID 
apBioGRID 
CG8214BioGRID 
CG6686BioGRID 
CG32306BioGRID 
CG32306BioGRID 
ImpBioGRID 
ifBioGRID 
hayBioGRID 
fdlBioGRID 
CG42684BioGRID 
Gas8BioGRID 
grauBioGRID 
CoproxBioGRID 
HsfBioGRID 
ifBioGRID 
lokBioGRID 
MED26BioGRID 
NnaDBioGRID 
CG8801BioGRID 
CG8783BioGRID 
EG:25E8.4BioGRID 
aubBioGRID 
Myt1BioGRID 
PofBioGRID 
proPo-A3BioGRID 
MEP-1BioGRID 
ImpBioGRID 
GSBioGRID 
Nipped-ABioGRID 
Cp110BioGRID 
HsfBioGRID 
HsfBioGRID 
HsfBioGRID 
CG13260BioGRID 
BioGRID 
Tm1BioGRID 
CG8712BioGRID 
gusBioGRID 
mrjBioGRID 
BioGRID 
CG8214BioGRID 
bolyBioGRID 
dupBioGRID 
Ady43ABioGRID 
CG8728-RABioGRID 
wdeBioGRID 
lwrBioGRID 
CG11486-RKBioGRID 
CG32306BioGRID 
yuBioGRID 
CG12723BioGRID 
GSBioGRID 
CG32985BioGRID 
Tm1BioGRID 
CG10825BioGRID 
Tm1BioGRID 
TwdlWBioGRID 
CG3056-RBBioGRID 
CG10825BioGRID 
growlBioGRID 
GSBioGRID 
CG42270BioGRID 
ifBioGRID 
ImpBioGRID 
gryBioGRID 
CG11486BioGRID 
CG32306-RCBioGRID 
Mmp2BioGRID 
CG1602BioGRID 
muraBioGRID 
TwdlEBioGRID 
CG7387BioGRID 
CG10825BioGRID 
CG12861BioGRID 
CG7634BioGRID 
ERRBioGRID 
CG18278BioGRID 
mu2BioGRID 
CG11486BioGRID 
touBioGRID 
Tm1BioGRID 
CG6686BioGRID 
skapBioGRID 
CG1074BioGRID 
CycKBioGRID 
CG7139BioGRID 
CG11486-RBBioGRID 
mTTFBioGRID 
toyBioGRID 
bip2BioGRID 
Brd8BioGRID 
wocBioGRID 
CG10057BioGRID 
CG13597BioGRID 
CG5919BioGRID 
CG7669BioGRID 
CG7379BioGRID 
CG3610BioGRID 
CG6923-RBBioGRID 
CG6325-RABioGRID 
muraBioGRID 
skapBioGRID 
CG8236BioGRID 
CG11035BioGRID 
CG1024BioGRID 
CG1137-RABioGRID 
CG10333BioGRID 
bsfBioGRID 
CG4668BioGRID 
CG42389BioGRID 
CG6686BioGRID 
CG4496BioGRID 
SABioGRID 
DLPBioGRID 
CG18269BioGRID 
growlBioGRID 
CG2926BioGRID 
CG8851BioGRID 
CG17612BioGRID 
Cp110BioGRID 
CG1324IntAct 
CG4769BioGRID 
CG5568BioGRID 
ERRBioGRID 
CG11652BioGRID 
CG10426BioGRID 
PcafBioGRID 
CG4753BioGRID 
CG9715BioGRID 
CG6333-RABioGRID 
Ulp1BioGRID 
dikBioGRID 
GSBioGRID 
Bap60BioGRID 
ImpBioGRID 
dylBioGRID 
gryBioGRID 
CG11486BioGRID 
CG32306-RABioGRID 
CG32306BioGRID 
mu2BioGRID 
CG42360BioGRID 
nordBioGRID 
CG4049BioGRID 
CG10932BioGRID 
CG1958BioGRID 
yuBioGRID 
mRpL16BioGRID 
CG7139BioGRID 
spn-ABioGRID 
RpA-70BioGRID 
CG9987BioGRID 
Ahcy13BioGRID 
sas-6BioGRID 
pr-set7BioGRID 
simaBioGRID 
sqhBioGRID 
Ada2bBioGRID 
Tom40BioGRID 
ToporsBioGRID 
Tm1BioGRID 
Tm1BioGRID 
Nipped-ABioGRID 
tudBioGRID 
UBCMINT 
weeBioGRID 
CG4622BioGRID 
MicalIntAct 
wocIntAct 
skapIntAct 
CG9715IntAct 
touIntAct 
bip2IntAct 
CG6923-RBIntAct 
CG1024IntAct 
CG18269IntAct 
CG2926IntAct 
CG17612IntAct 
ERRIntAct 
Ulp1IntAct 
BtbVIIIntAct 
CG42360IntAct 
CG4049IntAct 
pr-set7IntAct 
ToporsIntAct 
tudIntAct 
weeBioGRID 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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