SG ID

SG00000307 

UniProt Accession

Q8IH92_DROME;Q8IH92;  

Theoretical PI

FRAGMENT  

Molecular Weight

58321 Da  

Genbank Nucleotide ID

BT001357;  

Genbank Protein ID

AAN71112.1; 

Gene Name

p53 

Gene Synonyms/Alias

ORFNames=CG10873 

Protein Name

 

Protein Synonyms/Alias

SubName: AT28346pFlags: Fragment 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. W. J. Lu, J. Chapo, I. Roig and J. M. Abrams (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328(5983): 1278-81. 

Abstract
The evolutionary appearance of p53 protein probably preceded its role in tumor suppression, suggesting that there may be unappreciated functions for this protein. Using genetic reporters as proxies to follow in vivo activation of the p53 network in Drosophila, we discovered that the process of meiotic recombination instigates programmed activation of p53 in the germ line. Specifically, double-stranded breaks in DNA generated by the topoisomerase Spo11 provoked functional p53 activity, which was prolonged in cells defective for meiotic DNA repair. This intrinsic stimulus for the p53 regulatory network is highly conserved because Spo11-dependent activation of p53 also occurs in mice. Our findings establish a physiological role for p53 in meiosis and suggest that tumor-suppressive functions may have been co-opted from primordial activities linked to recombination. PMID: [20522776] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0000785	C:chromatin	IBA:RefGenome.
GO:0005829	C:cytosol	IBA:RefGenome.
GO:0005667	C:transcription factor complex	IBA:RefGenome.
GO:0003682	F:chromatin binding	IBA:RefGenome.
GO:0003684	F:damaged DNA binding	IBA:RefGenome.
GO:0003690	F:double-stranded DNA binding	IBA:RefGenome.
GO:0043565	F:sequence-specific DNA binding	IBA:RefGenome.
GO:0003700	F:sequence-specific DNA binding transcription factor activity	IBA:RefGenome.
GO:0044212	F:transcription regulatory region DNA binding	IEA:InterPro.
GO:0006919	P:activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP:FlyBase.
GO:0034644	P:cellular response to UV	IBA:RefGenome.
GO:0008340	P:determination of adult lifespan	IMP:FlyBase.
GO:0042771	P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	IMP:FlyBase.
GO:0006978	P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IBA:RefGenome.
GO:0035234	P:germ cell programmed cell death	IMP:FlyBase.
GO:0031571	P:mitotic cell cycle G1/S transition DNA damage checkpoint	IBA:RefGenome.
GO:0046533	P:negative regulation of photoreceptor cell differentiation	IMP:FlyBase.
GO:0000122	P:negative regulation of transcription from RNA polymerase II promoter	IBA:RefGenome.
GO:0048477	P:oogenesis	IGI:FlyBase.
GO:0045787	P:positive regulation of cell cycle	IGI:FlyBase.
GO:0045893	P:positive regulation of transcription, DNA-dependent	IDA:FlyBase.
GO:0007131	P:reciprocal meiotic recombination	IMP:FlyBase.
GO:0042127	P:regulation of cell proliferation	IMP:FlyBase.
GO:0043523	P:regulation of neuron apoptotic process	IBA:RefGenome.
GO:0046620	P:regulation of organ growth	IMP:FlyBase.
GO:0010332	P:response to gamma radiation	IBA:RefGenome.
GO:0010165	P:response to X-ray	IBA:RefGenome.
GO:0042246	P:tissue regeneration	IMP:FlyBase.

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Interpro

IPR008967;    p53-like_TF_DNA-bd.
IPR012346;    p53/RUNT-type_TF_DNA-bd.
IPR024631;    p53_C_Drosophila.
IPR011615;    p53_DNA-bd.
IPR002117;    p53_tumour_suppressor.
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Pfam

PF00870;    P53;    1.
PF11619;    P53_C;    1.
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SMART

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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 1888 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 519 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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