SG ID

SG00000315 

UniProt Accession

Q0E8D8_DROME;Q0E8D8;  

Theoretical PI

6.27  

Molecular Weight

63186 Da  

Genbank Nucleotide ID

AE014296; AE014296;  

Genbank Protein ID

ABI31259.1; ABI31260.1; 

Gene Name

Msi 

Gene Synonyms/Alias

ORFNames=Dmel_CG32178 

Protein Name

 

Protein Synonyms/Alias

SubName: Male-specific insect derived growth factor, isoform BSubName: Male-specific insect derived growth factor, isoform C 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. T. Matsushita, I. Fujii-Taira, Y. Tanaka, K. J. Homma and S. Natori (2000) Male-specific IDGF, a novel gene encoding a membrane-bound extracellular signaling molecule expressed exclusively in testis of Drosophila melanogaster. J Biol Chem 275(47): 36934-41. 

Abstract
We identified a novel gene of Drosophila melanogaster, Male-specific IDGF (MSI), encoding a transmembrane signaling molecule with exclusive expression in the testis. This molecule (MSI) contains a single transmembrane domain and has 35% amino acid identity with insect-derived growth factor (IDGF), a soluble growth factor for embryonic cells of the flesh fly, Sarcophaga peregrina. When MSI was exogenously expressed in Schneiders's line 2 cells, it was shown to be localized on the cell surface and exhibits growth factor activity, suggesting that MSI is a membrane-bound extracellular signaling molecule. Gene expression studies revealed that MSI mRNA was restricted to mature primary spermatocytes, whereas MSI was detected in the cells at the later developmental stages. Analysis using four meiotic arrest mutants, aly, can, mia, and sa suggested that MSI is involved in spermiogenesis, the final differentiation step of spermatogenesis. These results suggest that MSI is an extracellular signaling molecule participating in spermatogenesis and is a new member of the IDGF family. PMID: [10967093] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005615	C:extracellular space	IBA:RefGenome.
GO:0016021	C:integral to membrane	ISS:FlyBase.
GO:0005624	C:membrane fraction	IDA:FlyBase.
GO:0004000	F:adenosine deaminase activity	IBA:RefGenome.
GO:0006154	P:adenosine catabolic process	IBA:RefGenome.
GO:0043103	P:hypoxanthine salvage	IBA:RefGenome.
GO:0046103	P:inosine biosynthetic process	IBA:RefGenome.
GO:0009168	P:purine ribonucleoside monophosphate biosynthetic process	IEA:InterPro.
GO:0007286	P:spermatid development	IEP:FlyBase.

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Interpro

IPR001365;    A/AMP_deaminase_dom.
IPR013659;    A_deaminase_N.
IPR006331;    Ad_deam-like.
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Pfam

PF00962;    A_deaminase;    1.
PF08451;    A_deaminase_N;    1.
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SMART

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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 542 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

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