SG ID

SG00000321 

UniProt Accession

Q2PDT8_DROME;Q2PDT8;  

Theoretical PI

5.26  

Molecular Weight

76267 Da  

Genbank Nucleotide ID

AE014134;  

Genbank Protein ID

ABC65903.1; 

Gene Name

yuri 

Gene Synonyms/Alias

ORFNames=Dmel_CG31732 

Protein Name

 

Protein Synonyms/Alias

SubName: Yuri gagarin, isoform F 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. M. J. Texada, R. A. Simonette, C. B. Johnson, W. J. Deery and K. M. Beckingham (2008) Yuri gagarin is required for actin, tubulin and basal body functions in Drosophila spermatogenesis. J Cell Sci 121(Pt 11): 1926-36. 

Abstract
Males of the genus Drosophila produce sperm of remarkable length. Investigation of giant sperm production in Drosophila melanogaster has demonstrated that specialized actin and microtubule structures play key roles. The gene yuri gagarin (yuri) encodes a novel protein previously identified through its role in gravitaxis. A male-sterile mutation of yuri has revealed roles for Yuri in the functions of the actin and tubulin structures of spermatogenesis. Yuri is a component of the motile actin cones that individualize the spermatids and is essential for their formation. Furthermore, Yuri is required for actin accumulation in the dense complex, a microtubule-rich structure on the sperm nuclei thought to strengthen the nuclei during elongation. In the yuri mutant, late clusters of syncytial nuclei are deformed and disorganized. The basal bodies are also mispositioned on the nuclei, and the association of a specialized structure, the centriolar adjunct (CA), with the basal body is lost. Some of these nuclear defects might underlie a further unexpected abnormality PMID: [18477609] 

2. M. P. Kracklauer, H. M. Wiora, W. J. Deery, X. Chen, B. Bolival, Jr., D. Romanowicz, R. A. Simonette, M. T. Fuller, J. A. Fischer and K. M. Beckingham (2010) The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus. J Cell Sci 123(Pt 16): 2763-72. 

Abstract
Maintaining the proximity of centrosomes to nuclei is important in several cellular contexts, and LINC complexes formed by SUN and KASH proteins are crucial in this process. Here, we characterize the presumed Drosophila ortholog of the mammalian SUN protein, sperm-associated antigen 4 (Spag4, previously named Giacomo), and demonstrate that Spag4 is required for centriole and nuclear attachment during spermatogenesis. Production of spag4 mRNA is limited to the testis, and Spag4 protein shows a dynamic pattern of association with the germline nuclei, including a concentration of protein at the site of attachment of the single spermatid centriole. In the absence of Spag4, nuclei and centrioles or basal bodies (BBs) dissociate from each other after meiosis. This role of Spag4 in centriolar attachment does not involve either of the two KASH proteins of the Drosophila genome (Klarsicht and MSP-300), but does require the coiled-coil protein Yuri Gagarin. Yuri shows an identical pattern of localization at the nuclear surface to Spag4 during spermatogenesis, and epistasis studies show that the activities of Yuri and dynein-dynactin are downstream of spag4 in this centriole attachment pathway. The later defects in spermatogenesis seen for yuri and spag4 mutants are similar, suggesting they could be secondary to initial disruption of events at the nuclear surface. PMID: [20647369] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005737	C:cytoplasm	IDA:FlyBase.
GO:0070865	C:investment cone	IDA:FlyBase.
GO:0005635	C:nuclear envelope	IDA:FlyBase.
GO:0032053	P:microtubule basal body organization	IDA:FlyBase.
GO:0007291	P:sperm individualization	IMP:FlyBase.

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 660 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt	Gene Symbol	Ref Databases
D8FT40_DROME	Ubx-RE	BioGRID
B7Z063_DROME	Rbp6	BioGRID
LARK_DROME	lark	BioGRID
MSIR6_DROME	Rbp6	BioGRID
Q9VGY3_DROME	CG14684	BioGRID
Q9VYE6_DROME	IP3K2	BioGRID
Q9VYE7_DROME	IP3K2	BioGRID
UBX_DROME	Ubx	BioGRID

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

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