SG00000329

SpermatogenesisOnline 1.0

Tag

Content

SG ID

SG00000329

UniProt Accession

Theoretical PI

Molecular Weight

Genbank Nucleotide ID

Genbank Protein ID

Gene Name

Gene Synonyms/Alias

Protein Name

Protein Synonyms/Alias

Organism

NCBI Taxonomy ID

Chromosome Location

chr:-;---;-

View in Ensembl genome browser

Function in Stage

meiotic

Function in Cell Type

spermatocyte

Description

Temporarily unavailable

The information of related literatures

1. E. Bucciarelli, M. G. Giansanti, S. Bonaccorsi and M. Gatti (2003) Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol 160(7): 993-9.

Abstract
A large body of work indicates that chromosomes play a key role in the assembly of both a centrosomal and centrosome-containing spindles. In animal systems, the absence of chromosomes either prevents spindle formation or allows the assembly of a metaphase-like spindle that fails to evolve into an ana-telophase spindle. Here, we show that Drosophila secondary spermatocytes can assemble morphologically normal spindles in the absence of chromosomes. The Drosophila mutants fusolo and solofuso are severely defective in chromosome segregation and produce secondary spermatocytes that are devoid of chromosomes. The centrosomes of these anucleated cells form robust asters that give rise to bipolar spindles that undergo the same ana-telophase morphological transformations that characterize normal spindles. The cells containing chromosome-free spindles are also able to assemble regular cytokinetic structures and cleave normally. In addition, chromosome-free spindles normally accumulate the Aurora B kinase at their midzones. This suggests that the association of Aurora B with chromosomes is not a prerequisite for its accumulation at the central spindle, or for its function during cytokinesis. PMID: [12654903]

Figures for illustrating the function of this protein/gene

	Ref: E. Bucciarelli, M. G. Giansanti, S. Bonaccorsi and M. Gatti (2003) Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol 160(7): 993-9. PMID: [12654903]
	Ref: E. Bucciarelli, M. G. Giansanti, S. Bonaccorsi and M. Gatti (2003) Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol 160(7): 993-9. PMID: [12654903]
	Ref: E. Bucciarelli, M. G. Giansanti, S. Bonaccorsi and M. Gatti (2003) Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol 160(7): 993-9. PMID: [12654903]
	Ref: E. Bucciarelli, M. G. Giansanti, S. Bonaccorsi and M. Gatti (2003) Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol 160(7): 993-9. PMID: [12654903]
	Ref: E. Bucciarelli, M. G. Giansanti, S. Bonaccorsi and M. Gatti (2003) Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol 160(7): 993-9. PMID: [12654903]