Tag Content
SG ID
SG00000335 
UniProt Accession
Theoretical PI
6.03  
Molecular Weight
74492 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Mer 
Gene Synonyms/Alias
EMR2 
Protein Name
Moesin/ezrin/radixin homolog 2 
Protein Synonyms/Alias
Ezrin-moesin-radixin 2; Merlin;dMerlin 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:X;19584627-19587531;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. 

Abstract
Drosophila Merlin, an ortholog of the merlin protein encoded by the human Neurofibromatosis 2 (NF2) gene, is important for the regulation of cell proliferation and differentiation in the eye and wing. Also, it has been shown to be involved in male fertility in flies. In the present study, we formation using the comparative light and electron microscopic research of merlin mutants (mer3 and mer4) and ectopic expression of the Mer+ construct. Our work defines specific functions for Merlin in the mitochondria association and aggregation during the nebenkern formation and unfurling mitochondrial derivates during spermatid elongation. Possible role of Merlin as an adaptor protein that can link mitochondria with cytoskeleton is discussed. PMID: [21473116] 

2. N. V. Dorogova, E. M. Akhmametyeva, S. A. Kopyl, N. V. Gubanova, O. S. Yudina, L. V. Omelyanchuk and L. S. Chang (2008) The role of Drosophila Merlin in spermatogenesis. BMC Cell Biol 9(): 1. 

Abstract
BACKGROUND PMID: [18186933] 

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Figures for illustrating the function of this protein/gene
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signalingpathway, a signaling pathway that plays a pivotal role in organsize control and tumor suppression by restricting proliferationand promoting apoptosis. The core of this pathway is composed of akinase cascade wherein Hippo (Hpo), in complex with its regulatoryprotein Salvador (Sav), phosphorylates and activates Warts (Wts)in complex with its regulatory protein Mats, which in turnphosphorylates and inactivates the Yorkie (Yki) oncoprotein. Meracts synergistically along with Ex and Kibra to regulate the Hipposignaling pathway. 
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Subcellular Location
Cell junction, adherens junction. Cellmembrane; Peripheral membrane protein; Cytoplasmic side.Cytoplasm, cytoskeleton. Apical cell membrane. Note=Membrane-associated, adherens junctions and endocytic compartments.Cytoplasmic, punctate. 
Tissue Specificity
Expressed predominantly in the germline.Expressed in the developing oocyte from stage 6 to the end ofoogenesis and in the apical ends of follical cells from stage 10.Ubiquitous expression throughout embryogenesis with enhancedexpression in mesoderm of early embryos and midgut of lateembryos. In embryonic CNS, expression is seen in neuropil anddeveloping brain and is enhanced in neuronal cell bodies. Inembryonic PNS, expression is seen within the cell body. In thirdinstar larvae, expression is uniform in the eye imaginal disk andis enhanced at the morphogenetic furrow. In pupal eyes, expressionis seen in the cytoplasm of secondary and tertiary pigment cells,bristle precursor cells and rhabdomeres. 
Gene Ontology
GO IDGO termEvidence
GO:0005912 C:adherens junction IDA:UniProtKB.
GO:0016324 C:apical plasma membrane IDA:FlyBase.
GO:0005938 C:cell cortex IDA:FlyBase.
GO:0005856 C:cytoskeleton IEA:UniProtKB-SubCell.
GO:0019898 C:extrinsic to membrane IEA:InterPro.
GO:0016006 C:Nebenkern IDA:FlyBase.
GO:0007050 P:cell cycle arrest IGI:FlyBase.
GO:0007267 P:cell-cell signaling IEP:UniProtKB.
GO:0001751 P:compound eye photoreceptor cell differentiation IGI:FlyBase.
GO:0008101 P:decapentaplegic signaling pathway IGI:FlyBase.
GO:0032456 P:endocytic recycling IGI:FlyBase.
GO:0006897 P:endocytosis IEP:UniProtKB.
GO:0035329 P:hippo signaling cascade IGI:FlyBase.
GO:0007476 P:imaginal disc-derived wing morphogenesis IMP:FlyBase.
GO:0007112 P:male meiosis cytokinesis IMP:FlyBase.
GO:0060253 P:negative regulation of glial cell proliferation IMP:FlyBase.
GO:0046621 P:negative regulation of organ growth IMP:FlyBase.
GO:0042048 P:olfactory behavior IMP:FlyBase.
GO:0019094 P:pole plasm mRNA localization IMP:FlyBase.
GO:0042327 P:positive regulation of phosphorylation IGI:FlyBase.
GO:0042981 P:regulation of apoptotic process IGI:FlyBase.
GO:0001558 P:regulation of cell growth IEP:UniProtKB.
GO:0046669 P:regulation of compound eye retinal cell programmed cell death IMP:FlyBase.
GO:0035330 P:regulation of hippo signaling cascade IMP:UniProtKB.
GO:0006355 P:regulation of transcription, DNA-dependent IEA:UniProtKB-KW.
GO:0007291 P:sperm individualization IMP:FlyBase.
GO:0006351 P:transcription, DNA-dependent IEA:UniProtKB-KW.
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Interpro
IPR019749;    Band_41_domain.
IPR019750;    Band_41_fam.
IPR011174;    ERM.
IPR011259;    ERM_C.
IPR000798;    Ez/rad/moesin.
IPR014352;    FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748;    FERM_central.
IPR000299;    FERM_domain.
IPR018979;    FERM_N.
IPR018980;    FERM_PH-like_C.
IPR015788;    Merlin.
IPR008954;    Moesin.
IPR011993;    PH_like_dom.
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Pfam
PF00769;    ERM;    1.
PF09380;    FERM_C;    1.
PF00373;    FERM_M;    1.
PF09379;    FERM_N;    1.
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SMART
SM00295;    B41;    1.
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PROSITE
PS00660;    FERM_1;    FALSE_NEG.
PS00661;    FERM_2;    FALSE_NEG.
PS50057;    FERM_3;    1.
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PRINTS
PR00935;    BAND41.;   
PR00661;    ERMFAMILY.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    635       Moesin/ezrin/radixin homolog 2.
                             /FTId=PRO_0000219426.
DOMAIN       12    305       FERM.
CONFLICT    166    166       G -> R (in Ref. 4; AAM11326).
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Nucleotide Sequence
Length: 2573 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 635 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
coraIntAct 
CG10017BioGRID 
BubR1IntAct 
CG17050IntAct 
sbbBioGRID 
CG34340BioGRID 
amosIntAct 
RfabgIntAct 
AtpalphaDIP 
ATPsyn-betaIntAct 
bsBioGRID 
chnIntAct 
lin19DIP 
danrIntAct 
dppBioGRID 
Dhc64CIntAct 
sbbBioGRID 
forBioGRID 
exBioGRID 
grkBioGRID 
wawIntAct 
lidIntAct 
forBioGRID 
forBioGRID 
Lsd-2IntAct 
rab3-GEFIntAct 
marsIntAct 
coraBioGRID 
yrtBioGRID 
yrtBioGRID 
BubR1BioGRID 
CG30492BioGRID 
CG30492BioGRID 
CG30492BioGRID 
CG30492BioGRID 
CamtaBioGRID 
CG8290BioGRID 
DybBioGRID 
DybBioGRID 
DybBioGRID 
CG17050BioGRID 
CG10249BioGRID 
CG10249BioGRID 
Khc-73BioGRID 
sbbBioGRID 
betaTub56DBioGRID 
betaTub56DBioGRID 
PatjBioGRID 
CG30492BioGRID 
DybBioGRID 
CG10249-RDBioGRID 
Unc-89BioGRID 
CG4064BioGRID 
MbsBioGRID 
MbsBioGRID 
MbsBioGRID 
PnnBioGRID 
rab3-GEFBioGRID 
pod1BioGRID 
amosDIP 
RfabgBioGRID 
AtpalphaBioGRID 
ATPsyn-betaBioGRID 
_BioGRID 
Atpalpha-RDBioGRID 
bsBioGRID 
CamtaBioGRID 
CamtaBioGRID 
CamtaBioGRID 
yrtBioGRID 
RpS9-RABioGRID 
cactBioGRID 
chnBioGRID 
lin19BioGRID 
dppBioGRID 
Dhc64CBioGRID 
sbbBioGRID 
CamtaBioGRID 
marsBioGRID 
CG10249BioGRID 
AtpalphaBioGRID 
MntBioGRID 
MntBioGRID 
exBioGRID 
GpdhBioGRID 
grkBioGRID 
lidBioGRID 
forIntAct 
kibraBioGRID 
Lsd-2BioGRID 
rab3-GEFBioGRID 
marsBioGRID 
MerBioGRID 
MerBioGRID 
mnbIntAct 
modBioGRID 
MoeBioGRID 
armBioGRID 
bbxBioGRID 
_MINT 
PatjBioGRID 
Pgam5BioGRID 
prdBioGRID 
ade3BioGRID 
_MINT 
MEP-1BioGRID 
zorminBioGRID 
zorminBioGRID 
zorminBioGRID 
DybBioGRID 
E(Pc)BioGRID 
Lsd-2BioGRID 
Lsd-2BioGRID 
MhclBioGRID 
MhclBioGRID 
ade3BioGRID 
Unc-89BioGRID 
CG4562BioGRID 
iglBioGRID 
Rs1BioGRID 
CG9005-RABioGRID 
CG18446BioGRID 
wdeBioGRID 
BcDNA.GH03482BioGRID 
EG:63B12.5BioGRID 
zorminIntAct 
CG10543BioGRID 
MhclBioGRID 
ATPsyn-betaBioGRID 
CycGBioGRID 
MhclBioGRID 
MhclBioGRID 
CG6441BioGRID 
MbsBioGRID 
CG8765BioGRID 
CG17233BioGRID 
CG17233BioGRID 
l(2)08717BioGRID 
Mekk1BioGRID 
MbsBioGRID 
MntBioGRID 
EG:BACR7A4.19BioGRID 
CG6791BioGRID 
RpS9BioGRID 
iglBioGRID 
CycGBioGRID 
BEST:LD29214BioGRID 
CG8128IntAct 
sbbBioGRID 
sbbBioGRID 
chrwBioGRID 
daoBioGRID 
BcDNA.GH12326BioGRID 
EG:BACR42I17.11BioGRID 
EG:BACR7A4.19BioGRID 
bip2BioGRID 
_MINT 
CG11873BioGRID 
CG11935BioGRID 
polybromoBioGRID 
SMC1BioGRID 
Nup133BioGRID 
CG4936BioGRID 
CG17186BioGRID 
CG4562BioGRID 
cdiBioGRID 
Mekk1BioGRID 
CG31224BioGRID 
padBioGRID 
MhclBioGRID 
morBioGRID 
l(3)L1231BioGRID 
yrtBioGRID 
CG6923-RBBioGRID 
CG18476-RABioGRID 
CG6791BioGRID 
PnnBioGRID 
CG8021-RABioGRID 
CG31792BioGRID 
CG10333BioGRID 
CG5439BioGRID 
CG9934BioGRID 
CG12299BioGRID 
fu2BioGRID 
CG7627BioGRID 
CG6441BioGRID 
Liprin-alphaBioGRID 
CG2926BioGRID 
srpk79DIntAct 
netBioGRID 
CG2807BioGRID 
CG5001-RABioGRID 
BEST:CK02623BioGRID 
Pole2IntAct 
D19ABioGRID 
CG10147BioGRID 
Cdc27BioGRID 
rheaBioGRID 
CG18178BioGRID 
trnMINT 
SNCFBioGRID 
MbsBioGRID 
MbsBioGRID 
CG4877BioGRID 
CG13022MINT 
CG5589BioGRID 
CG3902-RABioGRID 
CG8765BioGRID 
CG17233BioGRID 
CG7556BioGRID 
GmapBioGRID 
GmapBioGRID 
CG11581IntAct 
Bap60BioGRID 
SpnBioGRID 
zorminBioGRID 
mwhBioGRID 
CG10543BioGRID 
Caf1-180BioGRID 
pod1BioGRID 
Rbcn-3ABioGRID 
CG4064BioGRID 
HLH4CBioGRID 
MntBioGRID 
Exp6BioGRID 
RpL22BioGRID 
RopBioGRID 
RpS9BioGRID 
savBioGRID 
sdDIP 
snaBioGRID 
bsBioGRID 
Sry-deltaBioGRID 
su(Hw)DIP 
Taf1DIP 
alphaTub84BBioGRID 
betaTub56DBioGRID 
CG13096BioGRID 
mnbMINT 
modIntAct 
MoeIntAct 
Khc-73IntAct 
armIntAct 
_IntAct 
PatjIntAct 
Pgam5IntAct 
prdIntAct 
ade3IntAct 
_IntAct 
MEP-1IntAct 
E(Pc)IntAct 
Unc-89IntAct 
iglIntAct 
CG18446IntAct 
CG33224IntAct 
wdeIntAct 
BcDNA.GH03482IntAct 
zorminIntAct 
BEST:LD29214IntAct 
modIntAct 
MbsIntAct 
CG8765IntAct 
sdIntAct 
BcDNA:GH02712;CG30492IntAct 
l(2)08717IntAct 
CG9005IntAct 
CG10543IntAct 
Caf1-180IntAct 
MntIntAct 
MhclIntAct 
CG6791IntAct 
CG9934IntAct 
srpk79DBioGRID 
CG7627IntAct 
CG4877IntAct 
AtpalphaIntAct 
CG10333IntAct 
CycGIntAct 
wocIntAct 
Mekk1IntAct 
CG8128MINT 
SpnIntAct 
DybIntAct 
sbbBioGRID 
sbbBioGRID 
fu2IntAct 
daoIntAct 
BcDNA.GH12326IntAct 
EG:BACR7A4.19IntAct 
bip2IntAct 
CG11873IntAct 
CG11935IntAct 
polybromoIntAct 
SMC1IntAct 
Nup133IntAct 
CG4936IntAct 
CG17186IntAct 
CG4562IntAct 
CG31224IntAct 
padIntAct 
morIntAct 
l(3)L1231IntAct 
yrtIntAct 
CG6923-RBIntAct 
CG18476-RAIntAct 
PnnIntAct 
CG8021-RAIntAct 
CG31792IntAct 
CG5439IntAct 
CG12299IntAct 
CG6441IntAct 
Liprin-alphaIntAct 
CG2926IntAct 
srpk79DBioGRID 
netBioGRID 
CG2807IntAct 
CG5001-RAIntAct 
chinmoIntAct 
_MINT 
BEST:CK02623IntAct 
Pole2BioGRID 
CG10147IntAct 
Cdc27IntAct 
rheaIntAct 
CG18178IntAct 
trnBioGRID 
SNCFIntAct 
CG13022BioGRID 
CG5589IntAct 
CG3902-RAIntAct 
CG17233MINT 
CG7556IntAct 
CG8128BioGRID 
GmapIntAct 
CG11581BioGRID 
Bap60IntAct 
BtbVIIIntAct 
mwhIntAct 
pod1IntAct 
Rbcn-3AIntAct 
CG4064IntAct 
HLH4CIntAct 
Exp6IntAct 
_MINT 
cdiIntAct 
RpL22IntAct 
RopDIP 
RpS9IntAct 
savIntAct 
snaIntAct 
bsBioGRID 
Sry-deltaIntAct 
su(Hw)IntAct 
Taf1IntAct 
alphaTub84BIntAct 
betaTub56DIntAct 
ttkIntAct 
CG13096IntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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