1. E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8.
Abstract Drosophila Merlin, an ortholog of the merlin protein encoded by the human Neurofibromatosis 2 (NF2) gene, is important for the regulation of cell proliferation and differentiation in the eye and wing. Also, it has been shown to be involved in male fertility in flies. In the present study, we formation using the comparative light and electron microscopic research of merlin mutants (mer3 and mer4) and ectopic expression of the Mer+ construct. Our work defines specific functions for Merlin in the mitochondria association and aggregation during the nebenkern formation and unfurling mitochondrial derivates during spermatid elongation. Possible role of Merlin as an adaptor protein that can link mitochondria with cytoskeleton is discussed. PMID: [21473116]
2. N. V. Dorogova, E. M. Akhmametyeva, S. A. Kopyl, N. V. Gubanova, O. S. Yudina, L. V. Omelyanchuk and L. S. Chang (2008) The role of Drosophila Merlin in spermatogenesis. BMC Cell Biol 9(): 1.
Figures for illustrating the function of this protein/gene
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Ref: E. U. Bolobolova, O. S. Iudina and N. V. Dorogova (2011) [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Tsitologiia 53(1): 31-8. PMID: [21473116]
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signalingpathway, a signaling pathway that plays a pivotal role in organsize control and tumor suppression by restricting proliferationand promoting apoptosis. The core of this pathway is composed of akinase cascade wherein Hippo (Hpo), in complex with its regulatoryprotein Salvador (Sav), phosphorylates and activates Warts (Wts)in complex with its regulatory protein Mats, which in turnphosphorylates and inactivates the Yorkie (Yki) oncoprotein. Meracts synergistically along with Ex and Kibra to regulate the Hipposignaling pathway.
Expressed predominantly in the germline.Expressed in the developing oocyte from stage 6 to the end ofoogenesis and in the apical ends of follical cells from stage 10.Ubiquitous expression throughout embryogenesis with enhancedexpression in mesoderm of early embryos and midgut of lateembryos. In embryonic CNS, expression is seen in neuropil anddeveloping brain and is enhanced in neuronal cell bodies. Inembryonic PNS, expression is seen within the cell body. In thirdinstar larvae, expression is uniform in the eye imaginal disk andis enhanced at the morphogenetic furrow. In pupal eyes, expressionis seen in the cytoplasm of secondary and tertiary pigment cells,bristle precursor cells and rhabdomeres.