SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000338 
UniProt Accession
Theoretical PI
9.45  
Molecular Weight
11369 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Cyt-c-d 
Gene Synonyms/Alias
CytC1, DC3 
Protein Name
Cytochrome c-1 
Protein Synonyms/Alias
Cytochrome c-distal; 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:2L;16715858-16719635;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. V. R. Gerbasi, J. B. Preall, D. E. Golden, D. W. Powell, T. D. Cummins and E. J. Sontheimer (2011) Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. Proc Natl Acad Sci U S A 108(8): 3204-9. 

Abstract
Small RNAs and a diverse array of protein partners control gene expression in eukaryotes through a variety of mechanisms. By combining siRNA affinity chromatography and mass spectrometry, we have identified the double-stranded RNA-binding domain protein Blanks to be an siRNA- and dsRNA-binding protein from Drosophila S2 cells. We find that Blanks is a nuclear factor that contributes to the efficiency of RNAi. Biochemical fractionation of a Blanks-containing complex shows that the Blanks complex is unlike previously described RNA-induced silencing complexes and associates with the DEAD-box helicase RM62, a protein previously implicated in RNA silencing. In flies, Blanks is highly expressed in testes tissues and is necessary for postmeiotic spermiogenesis, but loss of Blanks is not accompanied by detectable transposon derepression. Instead, genes related to innate immunity pathways are up-regulated in blanks mutant testes. These results reveal Blanks to be a unique component of a nuclear siRNA/dsRNA-binding complex that contributes to essential RNA silencing-related pathways in the male germ line. PMID: [21300896] 

2. E. Arama, M. Bader, M. Srivastava, A. Bergmann and H. Steller (2006) The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J 25(1): 232-43. 

Abstract
Cytochrome C has two apparently separable cellular functions PMID: [16362035] 

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Figures for illustrating the function of this protein/gene
Ref: V. R. Gerbasi, J. B. Preall, D. E. Golden, D. W. Powell, T. D. Cummins and E. J. Sontheimer (2011) Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. Proc Natl Acad Sci U S A 108(8): 3204-9. PMID: [21300896]
Function
Electron carrier protein. The oxidized form of thecytochrome c heme group can accept an electron from the heme groupof the cytochrome c1 subunit of cytochrome reductase. Cytochrome cthen transfers this electron to the cytochrome oxidase complex,the final protein carrier in the mitochondrial electron-transportchain. 
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Subcellular Location
Mitochondrion intermembrane space.Note=Loosely associated with the inner membrane. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005743 C:mitochondrial inner membrane ISS:FlyBase.
GO:0005758 C:mitochondrial intermembrane space IEA:UniProtKB-SubCell.
GO:0070469 C:respiratory chain IEA:UniProtKB-KW.
GO:0009055 F:electron carrier activity IDA:FlyBase.
GO:0020037 F:heme binding IEA:InterPro.
GO:0006919 P:activation of cysteine-type endopeptidase activity involved in apoptotic process IMP:FlyBase.
GO:0022900 P:electron transport chain IEA:UniProtKB-KW.
GO:0006119 P:oxidative phosphorylation ISS:FlyBase.
GO:0046669 P:regulation of compound eye retinal cell programmed cell death IMP:FlyBase.
GO:0007291 P:sperm individualization IMP:FlyBase.
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Interpro
IPR002327;    Cyt_c_1A/1B.
IPR009056;    Cyt_c_dom.
IPR003088;    Cyt_c_I.
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Pfam
PF00034;    Cytochrom_C;    1.
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SMART
PROSITE
PS51007;    CYTC;    1.
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PRINTS
PR00604;    CYTCHRMECIAB.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
INIT_MET      1      1       Removed (By similarity).
CHAIN         2    105       Cytochrome c-1.
                             /FTId=PRO_0000108259.
METAL        21     21       Iron (heme axial ligand).
METAL        83     83       Iron (heme axial ligand).
BINDING      17     17       Heme (covalent).
BINDING      20     20       Heme (covalent).
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Nucleotide Sequence
Length: 1645 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 105 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
CG5792BioGRID 
CG5792BioGRID 
HtrA2MINT 
CG5792IntAct 
CG5792DIP 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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