SG ID

SG00000362 

UniProt Accession

A1Z6Z9_DROME;A1Z6Z9;  

Theoretical PI

8.6  

Molecular Weight

207261 Da  

Genbank Nucleotide ID

AE013599;  

Genbank Protein ID

AAF59241.2; 

Gene Name

didum 

Gene Synonyms/Alias

ORFNames=Dmel_CG2146 

Protein Name

 

Protein Synonyms/Alias

SubName: Dilute class unconventional myosin, isoform AEC=3.6.1.3 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. V. Mermall, N. Bonafe, L. Jones, J. R. Sellers, L. Cooley and M. S. Mooseker (2005) Drosophila myosin V is required for larval development and spermatid individualization. Dev Biol 286(1): 238-55. 

Abstract
Class V myosins are multifunctional molecular motors implicated in vesicular traffic, RNA transport, and mechanochemical coupling of the actin and microtubule-based cytoskeletons. To assess the function of the single myosin V gene in Drosophila (MyoV), we have characterized both deletion and truncation alleles. Mutant animals exhibit no detectable defects during embryogenesis but are delayed in larval development; most die prior to 3rd instar. MyoV protein is widely distributed; however, there are no obvious cytological defects in mutant larval tissues where MyoV was normally highly expressed. Of the few adult MyoV mutant escapers, females were fertile but males were not. We examined the expression of MyoV during spermatogenesis. MyoV was associated with membranes, microtubule, and actin structures required for spermatid maturation; MyoV was strongly associated with the sperm nuclei during the maturation of the actin-rich investment cones that package spermatids in individual membranes. In MyoV mutant escaper males, the early stages of spermatogenesis were normal; however, in the later stages, the investment cones stained weakly for actin and their registration was disrupted; no mature sperm were produced. Our results suggest that MyoV contributes to the formation of the actin-based investment cones and acts to coordinate and/or anchor these structures and other components of the individualization complex. PMID: [16126191] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0016459	C:myosin complex	ISS:FlyBase.
GO:0030898	F:actin-dependent ATPase activity	IDA:FlyBase.
GO:0005524	F:ATP binding	IDA:FlyBase.
GO:0003774	F:motor activity	IEA:InterPro.
GO:0008595	P:anterior/posterior axis specification, embryo	IMP:FlyBase.
GO:0047497	P:mitochondrion transport along microtubule	IDA:FlyBase.
GO:0045856	P:positive regulation of pole plasm oskar mRNA localization	IMP:FlyBase.
GO:0042052	P:rhabdomere development	IMP:FlyBase.
GO:0007291	P:sperm individualization	IMP:FlyBase.

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Interpro

IPR018444;    Dil_domain.
IPR002710;    Dilute.
IPR000048;    IQ_motif_EF-hand-BS.
IPR001609;    Myosin_head_motor_dom.
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Pfam

PF01843;    DIL;    1.
PF00612;    IQ;    5.
PF00063;    Myosin_head;    1.
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SMART

SM00015;    IQ;    6.
SM00242;    MYSc;    1.
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PROSITE

PS51126;    DILUTE;    1.
PS50096;    IQ;    5.
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PRINTS

PR00193;    MYOSINHEAVY.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 1792 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt	Gene Symbol	Ref Databases
ATTB_DROME	AttB	IntAct
CALL_DROME	And	IntAct
MLC2_DROME	Mlc-c	BioGRID
O16158_DROME	Scp2	IntAct
Q0E8X9_DROME	yip3	IntAct
Q4V5R2_DROME	CG14247-RA	IntAct
Q7KSI6_DROME	CG34404	BioGRID
Q8SYK4_DROME	CG14545	IntAct
Q9U9Q2_DROME	Neos	BioGRID
Q9VF73_DROME	CG34404	BioGRID
Q9VF74_DROME	CG34404	BioGRID
Q9VFF6_DROME	CG3610	BioGRID
Q9VFI7_DROME	CG14850	IntAct
Q9VG03_DROME	CG11656	IntAct
Q9VJD4_DROME	Sgt	BioGRID
Q9VLS5_DROME	Rbsn-5	BioGRID
Q9VMK5_DROME	Vm26Ac	IntAct
Q9VQV0_DROME	CG31958	BioGRID
Q9VTV7_DROME	CG32100	BioGRID
Q9VUB1_DROME	CG9040	BioGRID
Q9VUS1_DROME	comm3	IntAct
Q9VWS1_DROME	CG6617	BioGRID
Q9W4A0_DROME	Rab-RP4	BioGRID
Q9W4M8_DROME	dgt4	BioGRID
Q9W513_DROME	CG17776	IntAct
A1Z7C1_DROME	Mlh1	BioGRID
CALL_DROME	And	BioGRID
E1JIY2_DROME	And	BioGRID
FAS2_DROME	Fas2	IntAct
O16158_DROME	Scp2	BioGRID
P18431-3	sgg	IntAct
Q0E8X9_DROME	yip3	BioGRID
Q4V5R2_DROME	CG14247-RA	BioGRID
Q8SYK4_DROME	CG14545	BioGRID
Q9VFI7_DROME	CG14850	BioGRID
Q9VG03_DROME	CG11656	BioGRID
Q9VMK5_DROME	Vm26Ac	BioGRID
Q9W513_DROME	CG17776	BioGRID
Q9XZ06_DROME	CG11092	BioGRID
SEM1A_DROME	Sema-1a	IntAct

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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