SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000367 
UniProt Accession
Theoretical PI
4.9  
Molecular Weight
194712 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Trf2 
Gene Synonyms/Alias
trf2 
Protein Name
 
Protein Synonyms/Alias
SubName: TATA box binding protein-related factor 2, isoform ESubName: TATA box binding protein-related factor 2, isoform FSubName: TRF2 
Organism
Drosophila melanogaster (Fruit fly) 
NCBI Taxonomy ID
7227 
Chromosome Location
chr:X;8303305-8324228;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. D. V. Kopytova, A. N. Krasnov, M. R. Kopantceva, E. N. Nabirochkina, J. V. Nikolenko, O. Maksimenko, M. M. Kurshakova, L. A. Lebedeva, M. M. Yerokhin, O. B. Simonova, L. I. Korochkin, L. Tora, P. G. Georgiev and S. G. Georgieva (2006) Two isoforms of Drosophila TRF2 are involved in embryonic development, premeiotic chromatin condensation, and proper differentiation of germ cells of both sexes. Mol Cell Biol 26(20): 7492-505. 

Abstract
The Drosophila TATA box-binding protein (TBP)-related factor 2 (TRF2 or TLF) was shown to control a subset of genes different from that controlled by TBP. Here, we have investigated the structure and functions of the trf2 gene. We demonstrate that it encodes two protein isoforms PMID: [17015475] 

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Figures for illustrating the function of this protein/gene
Ref: D. V. Kopytova, A. N. Krasnov, M. R. Kopantceva, E. N. Nabirochkina, J. V. Nikolenko, O. Maksimenko, M. M. Kurshakova, L. A. Lebedeva, M. M. Yerokhin, O. B. Simonova, L. I. Korochkin, L. Tora, P. G. Georgiev and S. G. Georgieva (2006) Two isoforms of Drosophila TRF2 are involved in embryonic development, premeiotic chromatin condensation, and proper differentiation of germ cells of both sexes. Mol Cell Biol 26(20): 7492-505. PMID: [17015475]
Ref: D. V. Kopytova, A. N. Krasnov, M. R. Kopantceva, E. N. Nabirochkina, J. V. Nikolenko, O. Maksimenko, M. M. Kurshakova, L. A. Lebedeva, M. M. Yerokhin, O. B. Simonova, L. I. Korochkin, L. Tora, P. G. Georgiev and S. G. Georgieva (2006) Two isoforms of Drosophila TRF2 are involved in embryonic development, premeiotic chromatin condensation, and proper differentiation of germ cells of both sexes. Mol Cell Biol 26(20): 7492-505. PMID: [17015475]
Ref: D. V. Kopytova, A. N. Krasnov, M. R. Kopantceva, E. N. Nabirochkina, J. V. Nikolenko, O. Maksimenko, M. M. Kurshakova, L. A. Lebedeva, M. M. Yerokhin, O. B. Simonova, L. I. Korochkin, L. Tora, P. G. Georgiev and S. G. Georgieva (2006) Two isoforms of Drosophila TRF2 are involved in embryonic development, premeiotic chromatin condensation, and proper differentiation of germ cells of both sexes. Mol Cell Biol 26(20): 7492-505. PMID: [17015475]
Ref: D. V. Kopytova, A. N. Krasnov, M. R. Kopantceva, E. N. Nabirochkina, J. V. Nikolenko, O. Maksimenko, M. M. Kurshakova, L. A. Lebedeva, M. M. Yerokhin, O. B. Simonova, L. I. Korochkin, L. Tora, P. G. Georgiev and S. G. Georgieva (2006) Two isoforms of Drosophila TRF2 are involved in embryonic development, premeiotic chromatin condensation, and proper differentiation of germ cells of both sexes. Mol Cell Biol 26(20): 7492-505. PMID: [17015475]
Function
 
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Subcellular Location
 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0001674 C:female germ cell nucleus IDA:FlyBase.
GO:0001673 C:male germ cell nucleus IDA:FlyBase.
GO:0005700 C:polytene chromosome IDA:FlyBase.
GO:0005669 C:transcription factor TFIID complex ISS:FlyBase.
GO:0003677 F:DNA binding IEA:InterPro.
GO:0003700 F:sequence-specific DNA binding transcription factor activity IDA:FlyBase.
GO:0022008 P:neurogenesis IMP:FlyBase.
GO:0035209 P:pupal development IMP:FlyBase.
GO:0006357 P:regulation of transcription from RNA polymerase II promoter IDA:FlyBase.
GO:0035075 P:response to ecdysone IMP:FlyBase.
GO:0051123 P:RNA polymerase II transcriptional preinitiation complex assembly IPI:GOC.
GO:0035071 P:salivary gland cell autophagic cell death IMP:FlyBase.
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Interpro
IPR012295;    Beta2_adaptin/TBP_C_dom.
IPR000814;    TBP.
IPR015445;    TBP-like.
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Pfam
PF00352;    TBP;    2.
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SMART
PROSITE
PRINTS
PR00686;    TIFACTORIID.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
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Nucleotide Sequence
Length: bp   Go to nucleotide: FASTA
Protein Sequence
Length: 1715 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
Comments