SG ID

SG00000370 

UniProt Accession

Q9VLP4_DROME;Q9VLP4;  

Theoretical PI

8.16  

Molecular Weight

73680 Da  

Genbank Nucleotide ID

AE014134;  

Genbank Protein ID

AAF52640.2; 

Gene Name

mtsh 

Gene Synonyms/Alias

CG7795 

Protein Name

 

Protein Synonyms/Alias

SubName: CG7795, isoform D 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. L. M. Bergner, F. E. Hickman, K. H. Wood, C. M. Wakeman, H. H. Stone, T. J. Campbell, S. B. Lightcap, S. M. Favors, A. C. Aldridge and K. G. Hales (2010) A novel predicted bromodomain-related protein affects coordination between meiosis and spermiogenesis in Drosophila and is required for male meiotic cytokinesis. DNA Cell Biol 29(9): 487-98. 

Abstract
Temporal coordination of meiosis with spermatid morphogenesis is crucial for successful generation of mature sperm cells. We identified a recessive male sterile Drosophila melanogaster mutant, mitoshell, in which events of spermatid morphogenesis are initiated too early, before meiotic onset. Premature mitochondrial aggregation and fusion lead to an aberrant mitochondrial shell around premeiotic nuclei. Despite successful meiotic karyokinesis, improper mitochondrial localization in mitoshell testes is associated with defective astral central spindles and a lack of contractile rings, leading to meiotic cytokinesis failure. We mapped and cloned the mitoshell gene and found that it encodes a novel protein with a bromodomain-related region. It is conserved in some insect lineages. Bromodomains typically bind to histone acetyl-lysine residues and therefore are often associated with chromatin. The Mitoshell bromodomain-related region is predicted to have an alpha helical structure similar to that of bromodomains, but not all the crucial residues in the ligand-binding loops are conserved. We speculate that Mitoshell may participate in transcriptional regulation of spermatogenesis-specific genes, though perhaps with different ligand specificity compared to traditional bromodomains. PMID: [20491580] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0055050	P:astral spindle assembly involved in male meiosis	IMP:FlyBase.
GO:0007112	P:male meiosis cytokinesis	IMP:FlyBase.
GO:0010635	P:regulation of mitochondrial fusion	IMP:FlyBase.
GO:0007283	P:spermatogenesis	IMP:FlyBase.

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 649 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt	Gene Symbol	Ref Databases
Q9VME5_DROME	slam	BioGRID
Q9VME5_DROME	slam	MINT

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

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