SG ID

SG00000372 

UniProt Accession

Q0KHU2_DROME;Q0KHU2;  

Theoretical PI

9.11  

Molecular Weight

64452 Da  

Genbank Nucleotide ID

AE014298;  

Genbank Protein ID

ABI30974.1; 

Gene Name

Imp 

Gene Synonyms/Alias

ORFNames=Dmel_CG1691 

Protein Name

 

Protein Synonyms/Alias

SubName: IGF-II mRNA-binding protein, isoform I 

Drosophila melanogaster (Fruit fly) 

7227 

Temporarily unavailable 

The information of related literatures

1. J. J. Fabrizio, C. A. Hickey, C. Stabrawa, V. Meytes, J. A. Hutter, C. Talbert and N. Regis (2008) Imp (IGF-II mRNA-binding protein) is expressed during spermatogenesis in Drosophila melanogaster. Fly (Austin) 2(1): 47-52. 

Abstract
Drosophila spermatogenesis results in the production of sixtyfour ~2-mm spermatozoa from an individual founder cell. Little is known, however, about the elongation of spermatids to such an extraordinary length. In a partial screen of a GFP-tagged protein trap collection, four insertions were uncovered that exhibit expression toward the tail ends of spermatid cysts and within the apical tip of the testis, suggesting that these protein traps may represent genes involved in spermatid elongation and pre-meiotic spermatogenesis, respectively. Inverse PCR followed by cycle sequencing and BLAST revealed that all four protein traps represent insertions within Imp (IGF-IImRNA binding protein), a known translational regulator. Testis enhancer trap analysis also reveals Imp expression in the cells of the apical tip, suggesting transcription of Imp prior to the primary spermatocyte stage. Taken together, these results suggest a role for Imp in the male germline during both spermatid elongation and premeiotic spermatogenesis. PMID: [18820448] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0071013	C:catalytic step 2 spliceosome	IDA:FlyBase.
GO:0071011	C:precatalytic spliceosome	IDA:FlyBase.
GO:0000166	F:nucleotide binding	IEA:InterPro.
GO:0003723	F:RNA binding	IEA:InterPro.
GO:0000398	P:nuclear mRNA splicing, via spliceosome	IC:FlyBase.
GO:0007283	P:spermatogenesis	IEP:FlyBase.
GO:0051124	P:synaptic growth at neuromuscular junction	IMP:FlyBase.

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Interpro

IPR004087;    KH_dom.
IPR004088;    KH_dom_type_1.
IPR012677;    Nucleotide-bd_a/b_plait.
IPR000504;    RRM_dom.
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Pfam

PF00013;    KH_1;    4.
PF00076;    RRM_1;    1.
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SMART

SM00322;    KH;    4.
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PROSITE

PS50084;    KH_TYPE_1;    4.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 588 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt	Gene Symbol	Ref Databases
A8JPX0_DROME	CG34354	BioGRID
E1JJ00_DROME	CG34354	BioGRID
Q24253_DROME	Bap	BioGRID
Q8IMZ4_DROME	p53	BioGRID
Q8SZP2_DROME	TwdlE	BioGRID
Q9N6D8_DROME	p53	BioGRID
UFL1_DROME	CG1104	BioGRID

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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