SG ID

SG00000383 

UniProt Accession

F6PR57_HORSE;F6PR57;  

Theoretical PI

FRAGMENT  

Molecular Weight

20506 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

ECA.12985 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Uncharacterized proteinFlags: Fragment 

Equus caballus (Horse) 

9796 

Temporarily unavailable 

The information of related literatures

1. M. J. Yoon, T. Berger and J. F. Roser (2011) Localization of insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR) in equine testes. Reprod Domest Anim 46(2): 221-8. 

Abstract
The insulin-like growth factor-I (IGF-I) is a key regulator of reproductive functions. IGF-I actions are primarily mediated by IGF-IR. The main objective of this research was to evaluate the presence of IGF-I and IGF-I Receptor (IGF-IR) in stallion testicular tissue. The hypotheses of this study were (i) IGF-I and IGF-IR are present in stallion testicular cells including Leydig, Sertoli, and developing germ cells, and (ii) the immunolabelling of IGF-I and IGF-IR varies with age. Testicular tissues from groups of 4 stallions in different developmental ages were used. Rabbit anti-human polyclonal antibodies against IGF-I and IGF-IR were used as primary antibodies for immunohistochemistry and Western blot. At the pre-pubertal and pubertal stages, IGF-I immunolabelling was present in spermatogonia and Leydig cells. At post-pubertal, adult and aged stages, immunolabelling of IGF-I was observed in spermatogenic cells (spermatogonia, spermatocyte, spermatid, and spermatozoa) and Leydig cells. Immunolabelling of IGF-IR was observed in spermatogonia and Leydig cells at the pre-pubertal stage. The immunolabelling becomes stronger as the age of animals advance through the post-pubertal stage. Strong immunolabelling of IGF-IR was observed in spermatogonia and Leydig cells at post-puberty, adult and aged stallions; and faint labelling was seen in spermatocytes at these ages. Immunolabelling of IGF-I and IGF-IR was not observed in Sertoli cells. In conclusion, IGF-I is localized in equine spermatogenic and Leydig cells, and IGF-IR is present in spermatogonia, spermatocytes and Leydig cells, suggesting that the IGF-I may be involved in equine spermatogenesis and Leydig cell function as a paracrine/autocrine factor. PMID: [20546172] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

Secreted (By similarity). 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005615	C:extracellular space	IEA:Compara.
GO:0006916	P:anti-apoptosis	IEA:Compara.
GO:0001974	P:blood vessel remodeling	IEA:Compara.
GO:0035630	P:bone mineralization involved in bone maturation	IEA:Compara.
GO:0048754	P:branching morphogenesis of a tube	IEA:Compara.
GO:0050650	P:chondroitin sulfate proteoglycan biosynthetic process	IEA:Compara.
GO:0031017	P:exocrine pancreas development	IEA:Compara.
GO:0010001	P:glial cell differentiation	IEA:Compara.
GO:0048839	P:inner ear development	IEA:Compara.
GO:0048009	P:insulin-like growth factor receptor signaling pathway	IEA:Compara.
GO:0048286	P:lung alveolus development	IEA:Compara.
GO:0060463	P:lung lobe morphogenesis	IEA:Compara.
GO:0060426	P:lung vasculature development	IEA:Compara.
GO:0030879	P:mammary gland development	IEA:Compara.
GO:0035264	P:multicellular organism growth	IEA:Compara.
GO:0014896	P:muscle hypertrophy	IEA:Compara.
GO:0045445	P:myoblast differentiation	IEA:Compara.
GO:0051450	P:myoblast proliferation	IEA:Compara.
GO:0014904	P:myotube cell development	IEA:Compara.
GO:0060766	P:negative regulation of androgen receptor signaling pathway	IEA:Compara.
GO:0008285	P:negative regulation of cell proliferation	IEA:Compara.
GO:0070373	P:negative regulation of ERK1 and ERK2 cascade	IEA:Compara.
GO:0034392	P:negative regulation of smooth muscle cell apoptotic process	IEA:Compara.
GO:0048015	P:phosphatidylinositol-mediated signaling	IEA:Compara.
GO:0042104	P:positive regulation of activated T cell proliferation	IEA:Compara.
GO:0070886	P:positive regulation of calcineurin-NFAT signaling cascade	IEA:Compara.
GO:0010613	P:positive regulation of cardiac muscle hypertrophy	IEA:Compara.
GO:0021940	P:positive regulation of cerebellar granule cell precursor proliferation	IEA:Compara.
GO:0043388	P:positive regulation of DNA binding	IEA:Compara.
GO:0050679	P:positive regulation of epithelial cell proliferation	IEA:Compara.
GO:0048146	P:positive regulation of fibroblast proliferation	IEA:Compara.
GO:0046326	P:positive regulation of glucose import	IEA:Compara.
GO:0045725	P:positive regulation of glycogen biosynthetic process	IEA:Compara.
GO:0045821	P:positive regulation of glycolysis	IEA:Compara.
GO:0043568	P:positive regulation of insulin-like growth factor receptor signaling pathway	IEA:Compara.
GO:0043410	P:positive regulation of MAPK cascade	IEA:Compara.
GO:0045840	P:positive regulation of mitosis	IEA:Compara.
GO:2000288	P:positive regulation of myoblast proliferation	IEA:Compara.
GO:0045669	P:positive regulation of osteoblast differentiation	IEA:Compara.
GO:0014068	P:positive regulation of phosphatidylinositol 3-kinase cascade	IEA:Compara.
GO:0033160	P:positive regulation of protein import into nucleus, translocation	IEA:Compara.
GO:0051897	P:positive regulation of protein kinase B signaling cascade	IEA:Compara.
GO:0046579	P:positive regulation of Ras protein signal transduction	IEA:Compara.
GO:0014911	P:positive regulation of smooth muscle cell migration	IEA:Compara.
GO:0048661	P:positive regulation of smooth muscle cell proliferation	IEA:Compara.
GO:0045944	P:positive regulation of transcription from RNA polymerase II promoter	IEA:Compara.
GO:0042523	P:positive regulation of tyrosine phosphorylation of Stat5 protein	IEA:Compara.
GO:0060527	P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IEA:Compara.
GO:0060736	P:prostate gland growth	IEA:Compara.
GO:0060741	P:prostate gland stromal morphogenesis	IEA:Compara.
GO:0032878	P:regulation of establishment or maintenance of cell polarity	IEA:Compara.
GO:0040014	P:regulation of multicellular organism growth	IEA:Compara.
GO:0014834	P:satellite cell maintenance involved in skeletal muscle regeneration	IEA:Compara.
GO:0060509	P:Type I pneumocyte differentiation	IEA:Compara.
GO:0060510	P:Type II pneumocyte differentiation	IEA:Compara.
GO:0030104	P:water homeostasis	IEA:Compara.

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Interpro

IPR022341;    IGF-I.
IPR016179;    Insulin-like.
IPR022350;    Insulin-like_growth_factor.
IPR022353;    Insulin_CS.
IPR022352;    Insulin_family.
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Pfam

PF00049;    Insulin;    1.
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SMART

SM00078;    IlGF;    1.
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PROSITE

PS00262;    INSULIN;    1.
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PRINTS

PR02002;    INSLNLIKEGF.;   
PR02005;    INSLNLIKEGF1.;   
PR00276;    INSULINFAMLY.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 184 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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