SG ID

SG00000385 

UniProt Accession

F6VWA8_HORSE;F6VWA8;  

Theoretical PI

FRAGMENT  

Molecular Weight

269961 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

IGF2R 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Uncharacterized proteinFlags: Fragment 

Equus caballus (Horse) 

9796 

Temporarily unavailable 

The information of related literatures

1. M. J. Yoon, T. Berger and J. F. Roser (2011) Localization of insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR) in equine testes. Reprod Domest Anim 46(2): 221-8. 

Abstract
The insulin-like growth factor-I (IGF-I) is a key regulator of reproductive functions. IGF-I actions are primarily mediated by IGF-IR. The main objective of this research was to evaluate the presence of IGF-I and IGF-I Receptor (IGF-IR) in stallion testicular tissue. The hypotheses of this study were (i) IGF-I and IGF-IR are present in stallion testicular cells including Leydig, Sertoli, and developing germ cells, and (ii) the immunolabelling of IGF-I and IGF-IR varies with age. Testicular tissues from groups of 4 stallions in different developmental ages were used. Rabbit anti-human polyclonal antibodies against IGF-I and IGF-IR were used as primary antibodies for immunohistochemistry and Western blot. At the pre-pubertal and pubertal stages, IGF-I immunolabelling was present in spermatogonia and Leydig cells. At post-pubertal, adult and aged stages, immunolabelling of IGF-I was observed in spermatogenic cells (spermatogonia, spermatocyte, spermatid, and spermatozoa) and Leydig cells. Immunolabelling of IGF-IR was observed in spermatogonia and Leydig cells at the pre-pubertal stage. The immunolabelling becomes stronger as the age of animals advance through the post-pubertal stage. Strong immunolabelling of IGF-IR was observed in spermatogonia and Leydig cells at post-puberty, adult and aged stallions; and faint labelling was seen in spermatocytes at these ages. Immunolabelling of IGF-I and IGF-IR was not observed in Sertoli cells. In conclusion, IGF-I is localized in equine spermatogenic and Leydig cells, and IGF-IR is present in spermatogonia, spermatocytes and Leydig cells, suggesting that the IGF-I may be involved in equine spermatogenesis and Leydig cell function as a paracrine/autocrine factor. PMID: [20546172] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0009986	C:cell surface	IEA:Compara.
GO:0030139	C:endocytic vesicle	IEA:Compara.
GO:0005768	C:endosome	IEA:Compara.
GO:0016021	C:integral to membrane	IEA:InterPro.
GO:0005624	C:membrane fraction	IEA:Compara.
GO:0005641	C:nuclear envelope lumen	IEA:Compara.
GO:0030140	C:trans-Golgi network transport vesicle	IEA:Compara.
GO:0005537	F:mannose binding	IEA:Compara.
GO:0005215	F:transporter activity	IEA:InterPro.

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Interpro

IPR000479;    CIMR.
IPR000562;    FN_type2_col-bd.
IPR013806;    Kringle-like.
IPR009011;    Man6P_isomerase_rcpt-bd_dom.
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Pfam

PF00878;    CIMR;    15.
PF00040;    fn2;    1.
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SMART

SM00059;    FN2;    1.
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PROSITE

PS00023;    FN2_1;    1.
PS51092;    FN2_2;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 2445 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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