SG ID

SG00000390 

UniProt Accession

F6S2G4_HORSE;F6S2G4;  

Theoretical PI

8.59  

Molecular Weight

61320 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

ECA.12642 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Uncharacterized protein 

Equus caballus (Horse) 

9796 

Temporarily unavailable 

The information of related literatures

1. C. A. Pearl, H. Mason and J. F. Roser (2011) Immunolocalization of estrogen receptor alpha, estrogen receptor beta and androgen receptor in the pre-, peri- and post-pubertal stallion testis. Anim Reprod Sci 125(1-4): 103-11. 

Abstract
In various species, androgens and estrogens regulate the function of testicular Leydig, Sertoli, peritubular myoid, and germ cells by binding to their respective receptors and eliciting a cellular response. Androgen receptor (AR) is expressed in Sertoli cells, peritubular myoid cells, Leydig cells and perivascular smooth muscle cells in the testis depending on the species, but its presence in germ cells remains controversial. Two different estrogen receptors have been identified, estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta), and their localization and function in testicular cells varies depending on the species, developmental stage of the cell and type of receptor. The localization of AR in an immature and mature stallion has been reported but estrogen receptors have only been reported for the mature stallion. In the present study, the localizations of AR and ERalpha/ERbeta were investigated in pre-pubertal, peri-pubertal and post-pubertal stallions. Testes were collected by routine castration from 21 horses, of light horse breeds (3 months-27 years). Animals were divided into the following age groups PMID: [21497463] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005739	C:mitochondrion	IEA:Compara.
GO:0005634	C:nucleus	IEA:UniProtKB-KW.
GO:0001046	F:core promoter sequence-specific DNA binding	IEA:Compara.
GO:0034056	F:estrogen response element binding	IEA:Compara.
GO:0003700	F:sequence-specific DNA binding transcription factor activity	IEA:InterPro.
GO:0005496	F:steroid binding	IEA:InterPro.
GO:0003707	F:steroid hormone receptor activity	IEA:InterPro.
GO:0008270	F:zinc ion binding	IEA:InterPro.
GO:0007420	P:brain development	IEA:Compara.
GO:0060743	P:epithelial cell maturation involved in prostate gland development	IEA:Compara.
GO:0030520	P:intracellular estrogen receptor signaling pathway	IEA:Compara.
GO:0060766	P:negative regulation of androgen receptor signaling pathway	IEA:Compara.
GO:0050680	P:negative regulation of epithelial cell proliferation	IEA:Compara.
GO:0000122	P:negative regulation of transcription from RNA polymerase II promoter	IEA:Compara.
GO:0001764	P:neuron migration	IEA:Compara.
GO:0001541	P:ovarian follicle development	IEA:Compara.
GO:0043065	P:positive regulation of apoptotic process	IEA:Compara.
GO:0051091	P:positive regulation of sequence-specific DNA binding transcription factor activity	IEA:Compara.
GO:0060740	P:prostate gland epithelium morphogenesis	IEA:Compara.
GO:0006351	P:transcription, DNA-dependent	IEA:UniProtKB-KW.
GO:0060065	P:uterus development	IEA:Compara.
GO:0060068	P:vagina development	IEA:Compara.

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Interpro

IPR021064;    Estrogen_rcpt_beta_N.
IPR008946;    Nucl_hormone_rcpt_ligand-bd.
IPR000536;    Nucl_hrmn_rcpt_lig-bd_core.
IPR024178;    Oestrogen_rcpt-rel.
IPR001723;    Str_hrmn_rcpt.
IPR001628;    Znf_hrmn_rcpt.
IPR013088;    Znf_NHR/GATA.
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Pfam

PF12497;    ERbeta_N;    1.
PF00104;    Hormone_recep;    1.
PF00105;    zf-C4;    1.
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SMART

SM00430;    HOLI;    1.
SM00399;    ZnF_C4;    1.
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PROSITE

PS00031;    NUCLEAR_REC_DBD_1;    1.
PS51030;    NUCLEAR_REC_DBD_2;    1.
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PRINTS

PR00398;    STRDHORMONER.;   
PR00047;    STROIDFINGER.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 550 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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