SG ID

SG00000393 

UniProt Accession

F1NM81_CHICK;F1NM81;  

Theoretical PI

6.7  

Molecular Weight

42214 Da  

Genbank Nucleotide ID

AADN02063940;  

Genbank Protein ID

 

Gene Name

ADIPOR1 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Uncharacterized protein 

Gallus gallus (Chicken) 

9031 

Temporarily unavailable 

The information of related literatures

1. O. M. Ocon-Grove, S. M. Krzysik-Walker, S. R. Maddineni, G. L. Hendricks, 3rd and R. Ramachandran (2008) Adiponectin and its receptors are expressed in the chicken testis. Reproduction 136(5): 627-38. 

Abstract
Adiponectin is an adipokine hormone that influences glucose utilization, insulin sensitivity, and energy homeostasis by signaling through two distinct receptors, ADIPOR1 and ADIPOR2. While adipose tissue is the primary site of adiponectin expression in the chicken, we previously reported that adiponectin and its receptors are expressed in several other tissues. The objectives of the present study are to characterize adiponectin, ADIPOR1, and ADIPOR2 expressions in the chicken testis and to determine whether sexual maturation affects the abundance of testicular adiponectin, ADIPOR1, and ADIPOR2 mRNAs. By RT-PCR and nucleotide sequencing, testicular adiponectin, ADIPOR1, and ADIPOR2 mRNAs were found to be identical to that expressed in the abdominal fat pad. Using anti-chicken adiponectin, ADIPOR1, or ADIPOR2 antibodies and immunohistochemistry, adiponectin-immunoreactive (ir) and ADIPOR1-ir cells were found exclusively in the peritubular cells as well as in Leydig cells. However, ADIPOR2-ir cells were found in the adluminal and luminal compartments of the seminiferous tubules as well as in interstitial cells. In particular, Sertoli cell syncytia, round spermatids, elongating spermatids, spermatozoa, and Leydig cells showed strong ADIPOR2 immunoreactivity. Using quantitative real-time PCR analyses, testicular ADIPOR1 and ADIPOR2 mRNA abundance were found to be 8.3- and 9-fold higher (P<0.01) in adult chickens compared with prepubertal chickens respectively, suggesting that sexual maturation is likely to be associated with an up-regulation of testicular ADIPOR1 and ADIPOR2 gene expressions. Collectively, our results indicate that adiponectin and its receptors are expressed in the chicken testis, where they are likely to influence steroidogenesis, spermatogenesis, Sertoli cell function as well as spermatozoa motility. PMID: [18660386] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0016021	C:integral to membrane	IEA:InterPro.
GO:0005886	C:plasma membrane	IEA:Compara.
GO:0042562	F:hormone binding	IEA:Compara.
GO:0004872	F:receptor activity	IEA:Compara.
GO:0019395	P:fatty acid oxidation	IEA:Compara.
GO:0009755	P:hormone-mediated signaling pathway	IEA:Compara.

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Interpro

IPR004254;    HlyIII-related.
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Pfam

PF03006;    HlyIII;    1.
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SMART

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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 375 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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