SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000408 
UniProt Accession
Theoretical PI
8.23  
Molecular Weight
21993 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
CLDN11 
Gene Synonyms/Alias
OSP, OTM 
Protein Name
Claudin-11 
Protein Synonyms/Alias
Oligodendrocyte-specific protein; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:3;170136653-170578169;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Expression of claudin-11, which builds up blood-testis barrier (BTB), was increased in decreased spermatogenesis, including in hypospermatogenesis, spermatocytic and maturation arrest, and Sertoli cell only (SCO) testes 
The information of related literatures
1. W. H. Nah, J. E. Lee, H. J. Park, N. C. Park and M. C. Gye (2011) Claudin-11 expression increased in spermatogenic defect in human testes. Fertil Steril 95(1): 385-8. 

Abstract
Expression of claudin-11, which builds up blood-testis barrier (BTB), was increased in decreased spermatogenesis, including in hypospermatogenesis, spermatocytic and maturation arrest, and Sertoli cell only (SCO) testes. Increased claudin-11 immunoreactivity was observed at the inter-Sertoli tight junctions in maturation arrest and in the cytoplasm of Sertoli cells in SCO. The late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the BTB in the human testis. PMID: [20850723] 

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Figures for illustrating the function of this protein/gene
Function
Plays a major role in tight junction-specificobliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). 
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Subcellular Location
Cell junction, tight junction. Cellmembrane; Multi-pass membrane protein. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0016021 C:integral to membrane IEA:UniProtKB-KW.
GO:0005923 C:tight junction ISS:UniProtKB.
GO:0005198 F:structural molecule activity IEA:InterPro.
GO:0016338 P:calcium-independent cell-cell adhesion ISS:UniProtKB.
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Interpro
IPR006187;    Claudin.
IPR003555;    Claudin11.
IPR017974;    Claudin_CS.
IPR004031;    PMP22/EMP/MP20/Claudin.
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Pfam
PF00822;    PMP22_Claudin;    1.
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SMART
PROSITE
PS01346;    CLAUDIN;    1.
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PRINTS
PR01077;    CLAUDIN.;   
PR01384;    CLAUDIN11.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    207       Claudin-11.
                             /FTId=PRO_0000144760.
TOPO_DOM      1      1       Cytoplasmic (Potential).
TRANSMEM      2     22       Helical; (Potential).
TOPO_DOM     23     82       Extracellular (Potential).
TRANSMEM     83    103       Helical; (Potential).
TOPO_DOM    104    122       Cytoplasmic (Potential).
TRANSMEM    123    143       Helical; (Potential).
TOPO_DOM    144    157       Extracellular (Potential).
TRANSMEM    158    178       Helical; (Potential).
TOPO_DOM    179    207       Cytoplasmic (Potential).
MOD_RES     197    197       Phosphoserine (By similarity).
MOD_RES     198    198       Phosphoserine (By similarity).
CONFLICT    160    160       A -> T (in Ref. 3; AAV38209/AAV38210).
CONFLICT    189    207       RFYYTAGSSSPTHAKSAHV -> VSTTLRALAPRLMRRVPT
                             YKRAARLPTEVL (in Ref. 1; AAC25187).
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Nucleotide Sequence
Length: 2243 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 207 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
CDIPTString 
CDIPTString 
TSPAN3HPRD 
TSPAN4HPRD 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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