SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000417 
UniProt Accession
Theoretical PI
5.35  
Molecular Weight
24608 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
RAB27B 
Gene Synonyms/Alias
 
Protein Name
Ras-related protein Rab-27B 
Protein Synonyms/Alias
C25KG; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:18;52495708-52562747;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
We speculate that during primate spermiogenesis, those proteins that compose microtubule-based and actin-based vesicle transport systems are actually present in the manchette and might possibly be involved in intramanchette transport. 
The information of related literatures
1. S. Hayasaka, Y. Terada, K. Suzuki, H. Murakawa, I. Tachibana, T. Sankai, T. Murakami, N. Yaegashi and K. Okamura (2008) Intramanchette transport during primate spermiogenesis. Asian J Androl 10(4): 561-8. 

Abstract
AIM PMID: [18478159] 

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Figures for illustrating the function of this protein/gene
Function
May be involved in targeting uroplakins to urothelialapical membranes (By similarity). 
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Subcellular Location
Membrane; Lipid-anchor. 
Tissue Specificity
Expressed primarily in testis. 
Gene Ontology
GO IDGO termEvidence
GO:0016324 C:apical plasma membrane IEA:Compara.
GO:0005795 C:Golgi stack IDA:UniProtKB.
GO:0032585 C:multivesicular body membrane IDA:UniProtKB.
GO:0005886 C:plasma membrane IDA:HPA.
GO:0030140 C:trans-Golgi network transport vesicle IDA:UniProtKB.
GO:0042589 C:zymogen granule membrane IEA:Compara.
GO:0005525 F:GTP binding ISS:UniProtKB.
GO:0003924 F:GTPase activity ISS:UniProtKB.
GO:0071985 P:multivesicular body sorting pathway IMP:UniProtKB.
GO:0045921 P:positive regulation of exocytosis IMP:UniProtKB.
GO:0015031 P:protein transport IEA:InterPro.
GO:0007264 P:small GTPase mediated signal transduction IEA:InterPro.
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Interpro
IPR005225;    Small_GTP-bd_dom.
IPR001806;    Small_GTPase.
IPR003579;    Small_GTPase_Rab_type.
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Pfam
PF00071;    Ras;    1.
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SMART
SM00175;    RAB;    1.
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PROSITE
PS51419;    RAB;    1.
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PRINTS
PR00449;    RASTRNSFRMNG.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
INIT_MET      1      1       Removed.
CHAIN         2    218       Ras-related protein Rab-27B.
                             /FTId=PRO_0000121224.
NP_BIND      16     24       GTP.
NP_BIND      74     78       GTP (By similarity).
NP_BIND     133    136       GTP.
NP_BIND     163    165       GTP.
MOTIF        38     46       Effector region (By similarity).
MOD_RES       2      2       N-acetylthreonine.
MOD_RES     218    218       Cysteine methyl ester (By similarity).
LIPID       216    216       S-geranylgeranyl cysteine (By
                             similarity).
LIPID       218    218       S-geranylgeranyl cysteine (By
                             similarity).
DISULFID    123    188
VARIANT      92     92       A -> T (in dbSNP:rs9966265).
                             /FTId=VAR_051714.
STRAND        7     16
HELIX        22     30
STRAND       37     54
STRAND       65     77
HELIX        78     89
STRAND       94    100
HELIX       104    115
TURN        122    124
STRAND      127    133
HELIX       138    140
HELIX       145    154
STRAND      159    162
TURN        164    166
HELIX       170    188
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Nucleotide Sequence
Length: 1042 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 218 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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