SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000430 
UniProt Accession
Theoretical PI
5.28  
Molecular Weight
57560 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
CEACAM1 
Gene Synonyms/Alias
BGP, BGP1 
Protein Name
Carcinoembryonic antigen-related cell adhesion molecule 1 
Protein Synonyms/Alias
Biliary glycoprotein 1;BGP-1 CD_antigen=CD66a;Flags: Precursor 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:19;43011458-43032661;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Its up-regulation in Sertoli cells accompanying spermatogenic damage may contribute to reconstruction and maintenance of the tubular structure of seminiferous tubules. Additionally, CEACAM1 is apparently involved in the angiogenesis of germ cell tumours 
The information of related literatures
1. H. Lauke, N. Kilic, R. Bozorgzad, M. Fernando, S. Neshat-Vahid, T. Pottek and S. Ergun (2004) Expression of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) in normal human Sertoli cells and its up-regulation in impaired spermatogenesis. Mol Hum Reprod 10(4): 247-52. 

Abstract
Carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) is usually expressed at the luminal surface of different epithelia and is up-regulated in endothelial cells during angiogenesis. Here, we demonstrate evidence of morphogenetic effects of CEACAM1 in spermatogenesis. CEACAM1 is detectable in normal testicular tissue and seminal fluid. It is present in the adluminal part of Sertoli cells extending only as far as the tight junctions between them. CEACAM1 immunostaining is significantly increased and extends to the basal part of Sertoli cells in the presence of carcinoma in situ. Also, in vitro-induced spermatogenetic disturbance leads to an enhanced CEACAM1 expression in Sertoli cells after 3 days of culture. Remarkably, seminiferous tubules containing exclusively Sertoli cells do not exhibit any CEACAM1 expression. CEACAM1 staining was absent in vascular endothelial cells of normal testicular tissue, but present in small blood vessels of seminomas. These data suggest that CEACAM1 expression in Sertoli cells depends on the presence of germ cells and plays a role in adhesive interactions between Sertoli and differentiating germ cells. Its up-regulation in Sertoli cells accompanying spermatogenic damage may contribute to reconstruction and maintenance of the tubular structure of seminiferous tubules. Additionally, CEACAM1 is apparently involved in the angiogenesis of germ cell tumours. PMID: [14985475] 

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Figures for illustrating the function of this protein/gene
Ref: H. Lauke, N. Kilic, R. Bozorgzad, M. Fernando, S. Neshat-Vahid, T. Pottek and S. Ergun (2004) Expression of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) in normal human Sertoli cells and its up-regulation in impaired spermatogenesis. Mol Hum Reprod 10(4): 247-52. PMID: [14985475]
Ref: H. Lauke, N. Kilic, R. Bozorgzad, M. Fernando, S. Neshat-Vahid, T. Pottek and S. Ergun (2004) Expression of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) in normal human Sertoli cells and its up-regulation in impaired spermatogenesis. Mol Hum Reprod 10(4): 247-52. PMID: [14985475]
Ref: H. Lauke, N. Kilic, R. Bozorgzad, M. Fernando, S. Neshat-Vahid, T. Pottek and S. Ergun (2004) Expression of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) in normal human Sertoli cells and its up-regulation in impaired spermatogenesis. Mol Hum Reprod 10(4): 247-52. PMID: [14985475]
Function
 
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Subcellular Location
Isoform 8: Cell membrane; Single-pass type Imembrane protein. Note=Localizes to sites of cell-cell contact. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005576 C:extracellular region IEA:UniProtKB-SubCell.
GO:0005887 C:integral to plasma membrane NAS:UniProtKB.
GO:0005624 C:membrane fraction TAS:ProtInc.
GO:0001525 P:angiogenesis NAS:UniProtKB.
GO:0016477 P:cell migration NAS:UniProtKB.
GO:0007156 P:homophilic cell adhesion NAS:UniProtKB.
GO:0007229 P:integrin-mediated signaling pathway NAS:UniProtKB.
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Interpro
IPR007110;    Ig-like.
IPR013783;    Ig-like_fold.
IPR003599;    Ig_sub.
IPR003598;    Ig_sub2.
IPR013106;    Ig_V-set.
IPR013151;    Immunoglobulin.
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Pfam
PF00047;    ig;    1.
PF07686;    V-set;    1.
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SMART
SM00409;    IG;    2.
SM00408;    IGc2;    2.
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PROSITE
PS50835;    IG_LIKE;    3.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     34
CHAIN        35    526       Carcinoembryonic antigen-related cell
                             adhesion molecule 1.
                             /FTId=PRO_0000014562.
TOPO_DOM     35    428       Extracellular (Potential).
TRANSMEM    429    452       Helical; (Potential).
TOPO_DOM    453    526       Cytoplasmic (Potential).
DOMAIN       35    142       Ig-like V-type.
DOMAIN      145    232       Ig-like C2-type 1.
DOMAIN      237    317       Ig-like C2-type 2.
DOMAIN      323    413       Ig-like C2-type 3.
MOD_RES      35     35       Pyrrolidone carboxylic acid.
CARBOHYD    104    104       N-linked (GlcNAc...).
CARBOHYD    111    111       N-linked (GlcNAc...).
CARBOHYD    115    115       N-linked (GlcNAc...).
CARBOHYD    152    152       N-linked (GlcNAc...).
CARBOHYD    182    182       N-linked (GlcNAc...) (Potential).
CARBOHYD    197    197       N-linked (GlcNAc...) (Potential).
CARBOHYD    208    208       N-linked (GlcNAc...).
CARBOHYD    224    224       N-linked (GlcNAc...).
CARBOHYD    232    232       N-linked (GlcNAc...) (Potential).
CARBOHYD    254    254       N-linked (GlcNAc...).
CARBOHYD    274    274       N-linked (GlcNAc...) (Potential).
CARBOHYD    288    288       N-linked (GlcNAc...) (Potential).
CARBOHYD    292    292       N-linked (GlcNAc...) (Potential).
CARBOHYD    302    302       N-linked (GlcNAc...) (Potential).
CARBOHYD    309    309       N-linked (GlcNAc...) (Potential).
CARBOHYD    345    345       N-linked (GlcNAc...) (Potential).
CARBOHYD    351    351       N-linked (GlcNAc...) (Potential).
CARBOHYD    363    363       N-linked (GlcNAc...).
CARBOHYD    378    378       N-linked (GlcNAc...).
CARBOHYD    405    405       N-linked (GlcNAc...).
DISULFID    167    215       Probable.
DISULFID    259    299       Probable.
DISULFID    348    396       Probable.
VAR_SEQ     143    416       Missing (in isoform 7).
                             /FTId=VSP_012222.
VAR_SEQ     320    416       ELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF
                             FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNP
                             ISKNQSDPIMLNVNY -> D (in isoform 6 and
                             isoform 11).
                             /FTId=VSP_010938.
VAR_SEQ     320    321       EL -> GK (in isoform 3).
                             /FTId=VSP_002478.
VAR_SEQ     321    416       LSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWFF
                             KNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPI
                             SKNQSDPIMLNVNY -> RQNLTMLPRLDSNSWAQAILPSV
                             SQSAEITD (in isoform 5).
                             /FTId=VSP_009227.
VAR_SEQ     321    416       LSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWFF
                             KNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPI
                             SKNQSDPIMLNVNY -> MAFHHVAKAGLKLLSSSNPPAST
                             SQSAKITD (in isoform 9).
                             /FTId=VSP_040571.
VAR_SEQ     321    351       LSPVVAKPQIKASKTTVTGDKDSVNLTCSTN -> SPVLGE
                             DEAVPGQHHPQHKPCQEGGCWDVLV (in isoform 4).
                             /FTId=VSP_002480.
VAR_SEQ     322    526       Missing (in isoform 3).
                             /FTId=VSP_002479.
VAR_SEQ     352    526       Missing (in isoform 4).
                             /FTId=VSP_002481.
VAR_SEQ     416    417       YN -> CK (in isoform 2).
                             /FTId=VSP_002482.
VAR_SEQ     418    526       Missing (in isoform 2).
                             /FTId=VSP_002483.
VAR_SEQ     459    464       RASDQR -> SSGPLQ (in isoform 8, isoform 9
                             and isoform 11).
                             /FTId=VSP_040572.
VAR_SEQ     460    468       ASDQRDLTE -> TTPMTHLTR (in isoform 10).
                             /FTId=VSP_040573.
VAR_SEQ     465    526       Missing (in isoform 8, isoform 9 and
                             isoform 11).
                             /FTId=VSP_040574.
VAR_SEQ     469    526       Missing (in isoform 10).
                             /FTId=VSP_040575.
VARIANT      35     35       Q -> K (in dbSNP:rs8111171).
                             /FTId=VAR_049844.
VARIANT      83     83       A -> V (in dbSNP:rs8110904).
                             /FTId=VAR_049845.
VARIANT     123    123       Q -> H (in dbSNP:rs8111468).
                             /FTId=VAR_049846.
VARIANT     376    376       Q -> R (in dbSNP:rs41355544).
                             /FTId=VAR_049847.
CONFLICT    142    142       P -> H (in Ref. 5; AAA57142).
STRAND       37     45
STRAND       51     56
STRAND       60     72
HELIX        75     77
STRAND       78     83
TURN         84     87
STRAND       88     91
STRAND       99    101
STRAND      107    109
HELIX       114    116
STRAND      118    126
STRAND      132    140
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Nucleotide Sequence
Length: 2197 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 526 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
ANXA2HPRD 
_HPRD 
_HPRD 
CD209HPRD 
ANXA2BioGRID 
_BioGRID 
CEACAM1HPRD 
CEACAM1HPRD 
CEACAM8BioGRID 
CLEC4MMINT 
FLNAHPRD 
EGFRHPRD 
FLNAHPRD 
INSRHPRD 
PXNBioGRID 
PTPN11BioGRID 
CEACAM8BioGRID 
_BioGRID 
FLNAHPRD 
FLNAHPRD 
PXNBioGRID 
SHC1MINT 
CEACAM3HPRD 
CEACAM6HPRD 
CEACAM8HPRD 
CLEC4MMINT 
MAP3K10HPRD 
PXNHPRD 
PTPN11HPRD 
PTPN6HPRD 
CEACAM8HPRD 
uspa1MINT 
_HPRD 
SHC1HPRD 
SRCHPRD 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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