SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000447 
UniProt Accession
Theoretical PI
7.89  
Molecular Weight
32819 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
HMOX1 
Gene Synonyms/Alias
HO, HO1 
Protein Name
Heme oxygenase 1 
Protein Synonyms/Alias
HO-1EC=1.14.99.3 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:22;35776354-35790207;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
In testes with varicocele, there are increases in 4-HNE-modified proteins, suggesting that oxidative stress is present. Increased HO-1 expression, mainly in Leydig cells, is considered to protect the cells against oxidative stresses in varicocele testes. 
The information of related literatures
1. K. Shiraishi and K. Naito (2005) Increased expression of Leydig cell haem oxygenase-1 preserves spermatogenesis in varicocele. Hum Reprod 20(9): 2608-13. 

Abstract
BACKGROUND PMID: [15878918] 

Back to Top
Figures for illustrating the function of this protein/gene
Function
Heme oxygenase cleaves the heme ring at the alphamethene bridge to form biliverdin. Biliverdin is subsequentlyconverted to bilirubin by biliverdin reductase. Underphysiological conditions, the activity of heme oxygenase ishighest in the spleen, where senescent erythrocytes aresequestrated and destroyed. 
Back to Top
Subcellular Location
Microsome. Endoplasmic reticulum. 
Tissue Specificity
Expressed at higher levels in renal cancertissue than in normal tissue (at protein level). 
Gene Ontology
GO IDGO termEvidence
GO:0005901 C:caveola IEA:Compara.
GO:0005829 C:cytosol IEA:Compara.
GO:0005789 C:endoplasmic reticulum membrane TAS:Reactome.
GO:0005615 C:extracellular space TAS:BHF-UCL.
GO:0005792 C:microsome ISS:BHF-UCL.
GO:0005730 C:nucleolus IEA:Compara.
GO:0005634 C:nucleus ISS:BHF-UCL.
GO:0020037 F:heme binding IDA:BHF-UCL.
GO:0004392 F:heme oxygenase (decyclizing) activity IMP:UniProtKB.
GO:0004630 F:phospholipase D activity IEA:Compara.
GO:0004871 F:signal transducer activity IMP:UniProtKB.
GO:0001525 P:angiogenesis TAS:BHF-UCL.
GO:0006916 P:anti-apoptosis IMP:BHF-UCL.
GO:0008219 P:cell death ISS:BHF-UCL.
GO:0006879 P:cellular iron ion homeostasis TAS:Reactome.
GO:0071276 P:cellular response to cadmium ion IEA:Compara.
GO:0071456 P:cellular response to hypoxia IEP:UniProtKB.
GO:0031670 P:cellular response to nutrient IEA:Compara.
GO:0008630 P:DNA damage response, signal transduction resulting in induction of apoptosis IEA:Compara.
GO:0001935 P:endothelial cell proliferation TAS:BHF-UCL.
GO:0034101 P:erythrocyte homeostasis IMP:BHF-UCL.
GO:0007588 P:excretion IC:BHF-UCL.
GO:0042167 P:heme catabolic process IDA:BHF-UCL.
GO:0006788 P:heme oxidation IDA:BHF-UCL.
GO:0007243 P:intracellular protein kinase cascade TAS:BHF-UCL.
GO:0034383 P:low-density lipoprotein particle clearance TAS:BHF-UCL.
GO:0043392 P:negative regulation of DNA binding IEA:Compara.
GO:0002686 P:negative regulation of leukocyte migration TAS:BHF-UCL.
GO:0032764 P:negative regulation of mast cell cytokine production IEA:Compara.
GO:0043305 P:negative regulation of mast cell degranulation IEA:Compara.
GO:0043524 P:negative regulation of neuron apoptotic process IEA:Compara.
GO:0043433 P:negative regulation of sequence-specific DNA binding transcription factor activity IEA:Compara.
GO:0048662 P:negative regulation of smooth muscle cell proliferation IDA:UniProtKB.
GO:0045766 P:positive regulation of angiogenesis IEA:Compara.
GO:0045768 P:positive regulation of anti-apoptosis IEA:Compara.
GO:0045080 P:positive regulation of chemokine biosynthetic process TAS:BHF-UCL.
GO:0043123 P:positive regulation of I-kappaB kinase/NF-kappaB cascade IMP:UniProtKB.
GO:0048661 P:positive regulation of smooth muscle cell proliferation IDA:UniProtKB.
GO:0045909 P:positive regulation of vasodilation IC:BHF-UCL.
GO:0051260 P:protein homooligomerization IDA:UniProtKB.
GO:0045765 P:regulation of angiogenesis TAS:BHF-UCL.
GO:0008217 P:regulation of blood pressure IEA:Compara.
GO:0051090 P:regulation of sequence-specific DNA binding transcription factor activity ISS:BHF-UCL.
GO:0043619 P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISS:BHF-UCL.
GO:0043627 P:response to estrogen stimulus IEA:Compara.
GO:0042542 P:response to hydrogen peroxide ISS:BHF-UCL.
GO:0035094 P:response to nicotine IDA:BHF-UCL.
GO:0007264 P:small GTPase mediated signal transduction IEA:Compara.
GO:0044281 P:small molecule metabolic process TAS:Reactome.
GO:0014806 P:smooth muscle hyperplasia TAS:BHF-UCL.
GO:0055085 P:transmembrane transport TAS:Reactome.
GO:0002246 P:wound healing involved in inflammatory response IMP:BHF-UCL.
Back to Top
Interpro
IPR002051;    Haem_Oase.
IPR016053;    Haem_Oase-like.
IPR016084;    Haem_Oase-like_multi-hlx.
IPR018207;    Haem_oxygenase_CS.
Back to Top
Pfam
PF01126;    Heme_oxygenase;    1.
Back to Top
SMART
PROSITE
PS00593;    HEME_OXYGENASE;    1.
Back to Top
PRINTS
PR00088;    HAEMOXYGNASE.;   
Back to Top
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    288       Heme oxygenase 1.
                             /FTId=PRO_0000209687.
METAL        25     25       Iron (heme axial ligand).
MOD_RES       1      1       N-acetylmethionine.
MOD_RES      39     39       N6-acetyllysine.
MOD_RES     229    229       Phosphoserine.
VARIANT       7      7       D -> H (in dbSNP:rs2071747).
                             /FTId=VAR_019165.
VARIANT     106    106       P -> L (in dbSNP:rs9282702).
                             /FTId=VAR_022156.
HELIX        13     20
HELIX        22     30
HELIX        32     38
HELIX        44     68
TURN         72     74
HELIX        75     77
HELIX        80     83
HELIX        86     97
HELIX       101    103
HELIX       109    124
HELIX       126    128
HELIX       129    155
STRAND      159    161
HELIX       165    167
HELIX       175    188
HELIX       193    220
Back to Top
Nucleotide Sequence
Length: 1550 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 288 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
Comments