Pbx4 in the mouse and PBX4 in humans are located on chromosome 8 and chromosome 19, respectively. Pbx4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.
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1. K. Wagner, A. Mincheva, B. Korn, P. Lichter and H. Popperl (2001) Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis. Mech Dev 103(1-2): 127-31.
Abstract Members of the Pbx family are involved in a diverse range of developmental processes including axial patterning and organogenesis. Pbx functions are in part mediated by the interaction of Pbx proteins with members of the Hox and Meis/Prep families. We have identified a fourth mammalian Pbx family member. Pbx4 in the mouse and PBX4 in humans are located on chromosome 8 and chromosome 19, respectively. Pbx4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase. PMID: [11335119]
CHAIN 1 374 Pre-B-cell leukemia transcription factor 4. /FTId=PRO_0000049241. DNA_BIND 210 272 Homeobox; TALE-type. VARIANT 169 169 V -> I (in dbSNP:rs8108180). /FTId=VAR_059355. VARIANT 177 177 M -> V (in dbSNP:rs8108981). /FTId=VAR_059356. VARIANT 283 283 T -> M (in a colorectal cancer sample; somatic mutation). /FTId=VAR_036439. CONFLICT 368 368 I -> T (in Ref. 1; BAG53471). Back to Top