SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000470 
UniProt Accession
Theoretical PI
5.94  
Molecular Weight
61652 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
WASF1 
Gene Synonyms/Alias
KIAA0269, SCAR1, WAVE1 
Protein Name
Wiskott-Aldrich syndrome protein family member 1 
Protein Synonyms/Alias
WASP family protein member 1 Protein WAVE-1; Verprolin homology domain-containing protein 1; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:6;110421022-110501207;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
The data support the possibility of a functional signalling unit established by WAVE1 and its associated proteins in the mid-piece of maturing sperm. 
The information of related literatures
1. V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. 

Abstract
BACKGROUND PMID: [15471936] 

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Figures for illustrating the function of this protein/gene
Ref: V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. PMID: [15471936]
Ref: V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. PMID: [15471936]
Ref: V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. PMID: [15471936]
Ref: V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. PMID: [15471936]
Ref: V. Y. Rawe, J. Ramalho-Santos, C. Payne, H. E. Chemes and G. Schatten (2004) WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis. Hum Reprod 19(11): 2594-604. PMID: [15471936]
Function
Downstream effector molecule involved in thetransmission of signals from tyrosine kinase receptors and smallGTPases to the actin cytoskeleton. Promotes formation of actinfilaments. Part of the WAVE complex that regulates lamellipodiaformation. The WAVE complex regulates actin filamentreorganization via its interaction with the Arp2/3 complex. 
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Subcellular Location
Cytoplasm, cytoskeleton. Note=Dot-likepattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas. 
Tissue Specificity
Highly expressed in brain. Lowly expressed intestis, ovary, colon, kidney, pancreas, thymus, small intestineand peripheral blood. 
Gene Ontology
GO IDGO termEvidence
GO:0015629 C:actin cytoskeleton TAS:ProtInc.
GO:0030027 C:lamellipodium IEA:Compara.
GO:0005741 C:mitochondrial outer membrane IEA:Compara.
GO:0005739 C:mitochondrion IDA:HPA.
GO:0030041 P:actin filament polymerization TAS:ProtInc.
GO:0006928 P:cellular component movement TAS:ProtInc.
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Interpro
IPR003124;    WH2_dom.
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Pfam
PF02205;    WH2;    1.
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SMART
SM00246;    WH2;    1.
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PROSITE
PS51082;    WH2;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    559       Wiskott-Aldrich syndrome protein family
                             member 1.
                             /FTId=PRO_0000188992.
DOMAIN      497    514       WH2.
COMPBIAS    278    283       Poly-Pro.
COMPBIAS    322    332       Poly-Pro.
COMPBIAS    348    359       Poly-Pro.
COMPBIAS    369    374       Poly-Pro.
COMPBIAS    424    435       Poly-Pro.
HELIX        26     81
TURN         85     87
HELIX        93     96
HELIX       114    116
HELIX       119    127
HELIX       134    140
HELIX       147    150
HELIX       156    181
HELIX       500    513
HELIX       531    540
TURN        541    543
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Nucleotide Sequence
Length: 1758 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 559 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
ABI2DIP 
ACTG1HPRD 
C3orf10HPRD 
CDK5HPRD 
CYFIP2HPRD 
DNMBPHPRD 
GNAI1HPRD 
PRKAR2AHPRD 
SPENString 
NCF1HPRD 
NCKAP1DIP 
PSTPIP1HPRD 
PFN1BioGRID 
At1g60430BioGRID 
PFN1BioGRID 
PRKAR2AHPRD 
RAC1DIP 
SRGAP3HPRD 
RAC1HPRD 
ABI1HPRD 
ABL1HPRD 
ACTBHPRD 
ARHGEF2BioGRID 
ACTR2HPRD 
GRB2HPRD 
BADHPRD 
BAIAP2BioGRID 
C3orf10MINT 
CDC42HPRD 
CRKHPRD 
CYFIP1DIP 
CYFIP2MINT 
ACTR2HPRD 
FYNHPRD 
GRB2HPRD 
IL12AHPRD 
IL8HPRD 
SPENString 
NCK1HPRD 
NCKAP1HPRD 
IL12AHPRD 
PFN1HPRD 
PS1TP5BP1HPRD 
PFN1HPRD 
_HPRD 
BADHPRD 
RAC1HPRD 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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