CHAIN         1    482       Histone deacetylase 1.
                             /FTId=PRO_0000114687.
REGION        9    321       Histone deacetylase.
ACT_SITE    141    141
MOD_RES      74     74       N6-acetyllysine.
MOD_RES     220    220       N6-acetyllysine.
MOD_RES     221    221       Phosphotyrosine.
MOD_RES     393    393       Phosphoserine.
MOD_RES     406    406       Phosphoserine.
MOD_RES     421    421       Phosphoserine; by CK2.
MOD_RES     423    423       Phosphoserine; by CK2.
MOD_RES     432    432       N6-methylated lysine; by EHMT2.
CROSSLNK    444    444       Glycyl lysine isopeptide (Lys-Gly)
                             (interchain with G-Cter in SUMO).
CROSSLNK    476    476       Glycyl lysine isopeptide (Lys-Gly)
                             (interchain with G-Cter in SUMO).
MUTAGEN     141    141       H->A: Abolishes histone deacetylase
                             activity.
MUTAGEN     287    287       F->Y: Abolishes interaction with CHFR;
                             when associated with I-297.
MUTAGEN     297    297       M->I: Abolishes interaction with CHFR;
                             when associated with Y-287.
MUTAGEN     391    482       Missing: Strongly decreases deacetylase
                             activity, and disrupts interaction with
                             NuRD and SIN3 complexes.
MUTAGEN     421    421       S->A: Strongly decreases deacetylase
                             activity, and disrupts interaction with
                             NuRD and SIN3 complexes.
MUTAGEN     421    421       S->D,E: Slightly decreases deacetylase
                             activity.
MUTAGEN     423    423       S->A: Strongly decreases deacetylase
                             activity, and disrupts interaction with
                             NuRD and SIN3 complexes.
MUTAGEN     423    423       S->D,E: Decreases deacetylase activity.
MUTAGEN     424    424       E->A: Slightly decreases deacetylase
                             activity, no effect on interaction with
                             NuRD and SIN3 complexes.
MUTAGEN     425    425       E->A: No effect on deacetylase activity,
                             no effect on interaction with NuRD and
                             SIN3 complexes.
MUTAGEN     426    426       E->A: Decreases deacetylase activity, and
                             disrupts interaction with NuRD and SIN3
                             complexes.
CONFLICT    312    312       W -> R (in Ref. 2; BAA08909).
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