SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000489 
UniProt Accession
Theoretical PI
10.01  
Molecular Weight
49348 Da  
Genbank Nucleotide ID
Genbank Protein ID
 
Gene Name
WIPF3 
Gene Synonyms/Alias
CR16 
Protein Name
WAS/WASL-interacting protein family member 3 
Protein Synonyms/Alias
Corticosteroids and regional expression protein 16 homolog; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:7;29846102-29956682;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
The expressions of the CR16 protein and mRNA decrease markedly in the testis of patients with idiopathic azoospermia, indicating a correlation with the pathogenesis of azoospermia. 
The information of related literatures
1. Z. N. Wen, W. J. Pang and W. P. Xiang (2010) [Expression of CR16 in the testis of patients with idiopathic azoospermia]. Zhonghua Nan Ke Xue 16(12): 1101-4. 

Abstract
OBJECTIVE PMID: [21348202] 

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Figures for illustrating the function of this protein/gene
Function
May be a regulator of cytoskeletal organization. Mayhave a role in spermatogenesis (By similarity). 
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Subcellular Location
Cytoplasm. Note=In hippocampal neuronscolocalizes with WASL in the cell body, axons and the growth cone(By similarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IDA:HPA.
GO:0005730 C:nucleolus IDA:HPA.
GO:0030154 P:cell differentiation IEA:UniProtKB-KW.
GO:0007275 P:multicellular organismal development IEA:UniProtKB-KW.
GO:0007283 P:spermatogenesis IEA:UniProtKB-KW.
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Interpro
IPR003124;    WH2_dom.
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Pfam
PF02205;    WH2;    1.
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SMART
SM00246;    WH2;    1.
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PROSITE
PS51082;    WH2;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    483       WAS/WASL-interacting protein family
                             member 3.
                             /FTId=PRO_0000337997.
DOMAIN       45     62       WH2.
MOTIF         3      8       Profilin-binding motif.
MOTIF        11     16       Profilin-binding motif.
MOTIF        20     25       Profilin-binding motif.
MOTIF        58     61       RLRK.
MOTIF       424    448       WASP-binding motif.
COMPBIAS    172    191       Poly-Pro.
COMPBIAS    223    239       Poly-Pro.
COMPBIAS    289    298       Poly-Pro.
VARIANT     321    321       E -> G (in dbSNP:rs3750092).
                             /FTId=VAR_043729.
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Nucleotide Sequence
Length: 157321 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 483 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
DNMBPBioGRID 
VSTM2LHPRD 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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